Patents by Inventor Lambertus Christiaan Johannes Dorssers

Lambertus Christiaan Johannes Dorssers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutants of human interleukin-3
    Patent number: 6500417
    Abstract: Biologically active deletion and substitution mutants of hIL-3 are provided. Preferred mutants are those having one or more deletions at the N-terminus (amino acids 1-14) and/or the C-terminus (amino acids 116-133, 120-130 and/or 130-133). Preferred substitution mutants include Cys16 →Ala16 and/or Cys84→Ala84, Glu50→Lys50 and Lys79 →Glu79. These mutants can be used to formulate pharmaceutical compositions. Also disclosed are antibodies directed against specific epitopes localized between amino acids 29 and 54.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: December 31, 2002
    Assignee: DSM N.V.
    Inventors: Lambertus Christiaan Johannes Dorssers, Robert Willem van Leen
  • Expression and purification of human interleukin-3 and muteins thereof
    Patent number: 6384194
    Abstract: Methods are provided for improved production of hIL-3 either in glycosylated form from mammalian and yeast cells or in unglycosylated form from prokaryotes. Recombinantly produced human IL-3 is purified in a series of steps, initially employing hydrophobic interaction, followed by ion exchange chromatography and gel filtration.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 7, 2002
    Assignee: DSM N.V.
    Inventors: Lambertus Christiaan Johannes Dorssers, Gerard Wagemaker, Yvonne Johanna Vos, Robert William Van Leen, Maria Ludovicus Nicolaas Persoon