Patents by Inventor Lambertus Thijs

Lambertus Thijs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes For Making Pregabalin And Intermediates Therefor
    Publication number: 20110245508
    Abstract: Processes for making a diester compound of formula (B) and for converting it to pregabalin, especially via a compound of formula (2), can provide several advantages. The compound (B) can be converted to the compound (2) via reductive hydrogenation.
    Type: Application
    Filed: May 2, 2011
    Publication date: October 6, 2011
    Inventor: Lambertus THIJS
  • Process for making montelukast and intermediates therefor
    Patent number: 7829716
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (20) is provided.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: November 9, 2010
    Assignee: Synthon Pharmaceuticals, Inc.
    Inventors: Arjanne Overeem, Reinerus G. Gieling, Jie Zhu, Lambertus Thijs
  • Process for making montelukast and intermediates therefor
    Patent number: 7786138
    Abstract: A compound of the following formula wherein R? is a straight or branched C1-C4 alkyl group is useful in processes associated with the synthesis of montelukast and its salts.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: August 31, 2010
    Assignee: Synthon BV
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR
    Publication number: 20100099879
    Abstract: The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula and salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.
    Type: Application
    Filed: October 9, 2009
    Publication date: April 22, 2010
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • PROCESSES FOR MAKING PREGABALIN AND INTERMEDIATES THEREFOR
    Publication number: 20090312560
    Abstract: Processes for making a diester compound of formula (B) and for converting it to pregabalin, especially via a compound of formula (2), can provide several advantages. The compound (B) can be converted to the compound (2) via reductive hydrogenation.
    Type: Application
    Filed: June 9, 2009
    Publication date: December 17, 2009
    Inventor: Lambertus Thijs
  • PROCESS FOR MAKING MONTELUKAST INTERMEDIATES
    Publication number: 20090270628
    Abstract: A process for making a montelukast intermediate of formula (1) is achieved by reacting a compound of formula (2): with a hydrogen source in the presence of a ruthenium catalyst of formula (9): or a dimer thereof, wherein n represents a number from 1 to 3, to form a compound of formula (1): generally in high enantiomeric purity.
    Type: Application
    Filed: April 24, 2009
    Publication date: October 29, 2009
    Inventors: Lambertus Thijs, Henar Tejedor Vinent
  • Process for making montelukast and intermediates therefor
    Patent number: 7601741
    Abstract: The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula and salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: October 13, 2009
    Assignee: Synthon BV
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • Processes for making pioglitazone and compounds of the processes
    Publication number: 20090216024
    Abstract: Pioglitazone can be made via a Darzens Condensation reaction in an industrially useful process.
    Type: Application
    Filed: April 27, 2009
    Publication date: August 27, 2009
    Inventors: Jie Zhu, Lambertus Thijs
  • Processes for making pioglitazone and compounds of the processes
    Patent number: 7541470
    Abstract: Pioglitazone can be made via a Darzens Condensation reaction in an industrially useful process.
    Type: Grant
    Filed: February 19, 2005
    Date of Patent: June 2, 2009
    Assignee: Synthon IP Inc.
    Inventors: Jie Zhu, Lambertus Thijs
  • Process for making aminoalkylphenyl carbamates and intermediates therefor
    Patent number: 7531684
    Abstract: A process for making aminoalkylphenyl carbamates, especially rivastigmine, can use less severe conditions using bis(p-nitrophenyl)carbonate (IX) as a phenol activator compound.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: May 12, 2009
    Assignee: Synthon BV
    Inventors: Henar Tejedor Vinent, Arjanne Overeem, Lambertus Thijs
  • PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR
    Publication number: 20090093636
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (11) is provided.
    Type: Application
    Filed: December 12, 2008
    Publication date: April 9, 2009
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • Process for making montelukast and intermediates therefor
    Patent number: 7501517
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (4) is provided.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: March 10, 2009
    Assignee: Synthon IP, Inc.
    Inventors: Arjanne Overeem, Reinerus G. Gieling, Jie Zhu, Lambertus Thijs
  • Process for making desvenlafaxine
    Patent number: 7491848
    Abstract: Desvenlafaxine is formed from venlafaxine by the use of a demethylating agent comprising a metal sulfide, such as sodium sulfide, and optionally selenium.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: February 17, 2009
    Assignee: Synthon IP Inc.
    Inventors: Karel Pospisilik, Lambertus Thijs
  • Process for making montelukast and intermediates therefor
    Patent number: 7476748
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (11) is provided.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: January 13, 2009
    Assignee: Synthon BV
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • PROCESS FOR MAKING AMINOALKYLPHENYL CARBAMATES AND INTERMEDIATES THEREFOR
    Publication number: 20080154057
    Abstract: A process for making aminoalkylphenyl carbamates, especially rivastigmine, can use less severe conditions using bis(p-nitrophenyl)carbonate (IX) as a phenol activator compound.
    Type: Application
    Filed: September 28, 2007
    Publication date: June 26, 2008
    Inventors: Henar Tejedor Vinent, Arjanne Overeem, Lambertus Thijs
  • Process for making desvenlafaxine
    Publication number: 20070299283
    Abstract: Desvenlafaxine is formed from venlafaxine by the use of a demethylating agent comprising a metal sulfide, such as sodium sulfide, and optionally selenium.
    Type: Application
    Filed: December 20, 2006
    Publication date: December 27, 2007
    Inventors: Karel Pospisilik, Lambertus Thijs
  • Processes for making pioglitazone and compounds of the processes
    Publication number: 20070167629
    Abstract: Pioglitazone can be made via a Darzens Condensation reaction in an industrially useful process.
    Type: Application
    Filed: February 19, 2005
    Publication date: July 19, 2007
    Inventors: Jie Zhu, Lambertus Thijs
  • PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR
    Publication number: 20070135642
    Abstract: A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (11) is provided.
    Type: Application
    Filed: November 20, 2006
    Publication date: June 14, 2007
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR
    Publication number: 20070135643
    Abstract: The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula and salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.
    Type: Application
    Filed: November 20, 2006
    Publication date: June 14, 2007
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal
  • PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR
    Publication number: 20070135480
    Abstract: A compound of the following formula wherein R? is a straight or branched C1-C4 alkyl group is useful in processes associated with the synthesis of montelukast and its salts.
    Type: Application
    Filed: November 20, 2006
    Publication date: June 14, 2007
    Inventors: Petr Benovsky, Lambertus Thijs, Arjanne Overeem, Jakub Castulik, Jie Zhu, Petr Bartos, Radomir Skoumal