Patents by Inventor Lan Cao

Lan Cao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220135931
    Abstract: The present disclosure relates to systems and methods for flow-through separation of paramagnetic particle-bound cells in a cell suspension containing both bound and unbound cells as well as systems and methods for removing paramagnetic particles from paramagnetic particle-bound cells or from a cell suspension with unbound cells. It further relates to a flow-through magnetic separation/debeading module and a flow-through spinning membrane debeading module.
    Type: Application
    Filed: October 15, 2021
    Publication date: May 5, 2022
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Fabio FACHIN, Rodney RIETZE, Michael R. GREENE, Lan CAO
  • Publication number: 20220108609
    Abstract: Methods, apparatus, computer program products Geohash-based traffic management are provided. The method comprises receiving, by one or more processing units, respective operating status data of one or more vehicles travelling within a Geohash cell; generating, by one or more processing units, one or more service messages based on the received respective operating status data according to one or more service specifications; and providing, by one or more processing units, at least one of the one or more service messages responsive to a request from a vehicle travelling within the Geohash cell.
    Type: Application
    Filed: October 7, 2020
    Publication date: April 7, 2022
    Inventors: Jun Qian, Cheng Luo, Lan Cao, Shiwen He, Ke Zhang, Yuan Yuan Jia
  • Patent number: 11287716
    Abstract: Methods and materials to fabricate electrochromic including electrochemical devices are disclosed. In particular, emphasis is placed on the composition, fabrication and incorporation of electrolytic sheets in these devices. Composition, fabrication and incorporation of redox layers and sealants suitable for these devices are also disclosed. Incorporation of EC devices in insulated glass system (IGU) windows is also disclosed.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: March 29, 2022
    Assignees: Polyceed Inc., Huntsman International LLC
    Inventors: Anoop Agrawal, Lori L. Adams, John P. Cronin, Zarif Farhana Mohd Aris, Lan Cao
  • Patent number: 11162065
    Abstract: The present disclosure relates to systems and methods for flow-through separation of paramagnetic particle-bound cells in a cell suspension containing both bound and unbound cells as well as systems and methods for removing paramagnetic particles from paramagnetic particle-bound cells or from a cell suspension with unbound cells. It further relates to a flow-through magnetic separation/debeading module and a flow-through spinning membrane debeading module.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: November 2, 2021
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Fabio Fachin, Rodney Rietze, Michael R. Greene, Lan Cao
  • Publication number: 20210315198
    Abstract: The present disclosure provides, among other things, a cryopreservation medium for cryopreserving mammalian cells, the medium comprising: dimethyl sulfoxide (DMSO), disaccharide, human serum, and IL-7 and/or IL-15. The present disclosure also provides, among other things, a cryopreservation medium for cryopreserving mammalian cells, the medium comprising: between about 1 w/v % and 10 w/v % dimethyl sulfoxide (DMSO), between about 0.25 w/v % and 5 w/v % disaccharide, and between about 10 w/v % and 90 w/v % human serum. The present disclosure also provides, among other things, a cryopreservation medium for cryopreserving mammalian cells, the medium comprising: between about 1 w/v % and 10 w/v % dimethyl sulfoxide (DMSO), between about 0.25 w/v % and 5 w/v % disaccharide, and between about 0.5 w/v % and 30 w/v % human serum albumin.
    Type: Application
    Filed: January 20, 2021
    Publication date: October 14, 2021
    Inventors: Lan Cao, Hui-Hsin Chang, Jianxin Hu, Xi Shi, Yutaka Nishimoto
  • Publication number: 20210292713
    Abstract: The present disclosure provides, among other things, a method for efficiently producing natural killer cells from induced pluripotent cells. The method includes the steps of: (I) culturing pluripotent stem cells in a culture medium to produce CD56+/CD3? immune cells.
    Type: Application
    Filed: February 26, 2021
    Publication date: September 23, 2021
    Inventors: Yu Qian, Hui-Hsin Chang, Xi Shi, Jianxin Hu, Lan Cao
  • Patent number: 11086181
    Abstract: Methods and materials to fabricate electrochromic including electrochemical devices are disclosed. In particular, emphasis is placed on the composition, fabrication and incorporation of electrolytic sheets in these devices. Composition, fabrication and incorporation of redox layers and sealants suitable for these devices are also disclosed. Incorporation of EC devices in insulated glass system (IGU) windows is also disclosed.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: August 10, 2021
    Assignees: Polyceed, Inc., Huntsman International LLC
    Inventors: Anoop Agrawal, Lori L. Adams, John P. Cronin, Lan Cao, Zarif Farhana Mohd Aris
  • Publication number: 20210109905
    Abstract: A method, system and computer program product for processing metrics data with graph data context analysis. Graph data representing one or more devices or sensors is stored into a first database, and metrics data generated by the devices or sensors is stored in a second database. The metrics data is then applied to the graph data for the context analysis, wherein the context analysis reflects the relationships of the devices or sensors in the graph data to the metrics data generated by the devices or sensors. The graph data comprises nodes for representing the devices or sensors, edges for representing a topology of the devices or sensors, and properties for storing the metrics data associated with the nodes and edges; and the metrics data comprises time-series data that is logged by the devices and sensors.
    Type: Application
    Filed: October 14, 2019
    Publication date: April 15, 2021
    Inventors: Shao Rong IL Li, Cheng Luo, Lan Cao, Cheng Cheng Dong
  • Patent number: 10757248
    Abstract: An approach for recommending activating a safety feature on a mobile device in a vehicle. The approach includes collecting sound characteristics. Furthermore, determining if the mobile device is moving faster than a predetermined velocity and invoking grouping service on a server. The approach determines the number of the mobile device in the vehicle and determines which one of the one or more of the mobile devices belongs to the user operating the vehicle and activating a safe drive mode feature on the mobile device belonging to the user of the vehicle.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: August 25, 2020
    Assignee: International Business Machines Corporation
    Inventors: Jun Qian, Xinlin Wang, Cheng Luo, Lan Cao, Cheng Cheng Dong
  • Publication number: 20200248130
    Abstract: The present disclosure relates to systems and methods for flow-through separation of paramagnetic particle-bound cells in a cell suspension containing both bound and unbound cells as well as systems and methods for removing paramagnetic particles from paramagnetic particle-bound cells or from a cell suspension with unbound cells. It further relates to a flow-through magnetic separation/debeading module and a flow-through spinning membrane debeading module.
    Type: Application
    Filed: January 10, 2020
    Publication date: August 6, 2020
    Inventors: Fabio Fachin, Rodney Rietze, Michael R. Greene, Lan Cao
  • Publication number: 20190269727
    Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), and compositions and reaction mixtures comprising the same.
    Type: Application
    Filed: December 27, 2016
    Publication date: September 5, 2019
    Inventors: Fabio Fachin, Lan Cao, Michael R. Greene, Tatiana Golovina
  • Patent number: 10036930
    Abstract: An electro-optic assembly comprises an adhesive layer and a layer of electro-optic material. The adhesive layer comprises a polymeric adhesive material and an ionic material having either its cation or its anion fixed to the polymeric adhesive material. The ionic material reduces the volume resistivity of the polymeric adhesive material and is not removed upon heating to 50° C. In a similar electro-optic assembly comprising an adhesive layer and a layer of electro-optic material, the adhesive layer comprises a polymeric adhesive material which has been subjected to dialysis or diafiltration to remove organic species having a molecular weight less than about 3,500, so that the adhesive material has a content of N-methylpyrrolidone not exceeding 500 ppm based upon the total weight of the adhesive layer and layer of electro-optic material.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: July 31, 2018
    Assignee: E Ink Corporation
    Inventors: Thomas H. Whitesides, Lan Cao
  • Patent number: 9881564
    Abstract: The invention provides materials and methods (including driving methods) for reducing the effects of remnant voltages in electro-optic displays.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: January 30, 2018
    Assignee: E Ink Corporation
    Inventors: Russell J. Wilcox, Thomas H. Whitesides, Karl Raymond Amundson, Guy M. Danner, Richard M. Webber, Charles Howie Honeyman, Lan Cao, Richard J. Paolini, Jr., Rajesh Chebiyam
  • Patent number: 9603894
    Abstract: The invention provides a solution to the problem of delivering molecules in a physiologically relevant manner to direct cell fate. For example, a Notch ligand molecule is presented in a microenvironment that mimics the environment encountered in vivo. Accordingly, the invention features a cell delivery vehicle comprising a biocompatible hydrogel or polymer and a composition that binds to a Notch receptor and methods of directing cell fate, e.g., stem cell differentiation, using such compositions.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: March 28, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Lan Cao, Kamal H. Bouhadir, David J. Mooney
  • Patent number: 9564088
    Abstract: The invention provides materials and methods (including driving methods) for reducing the effects of remnant voltages in electro-optic displays.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: February 7, 2017
    Assignee: E Ink Corporation
    Inventors: Russell J. Wilcox, Thomas H. Whitesides, Karl R. Amundson, Guy M. Danner, Richard M. Webber, Charles H. Honeyman, Lan Cao, Richard J. Paolini, Jr., Rajesh Chebiyam
  • Patent number: 9539309
    Abstract: The present invention comprises compositions, methods, and devices for delivering angiogenic factors and signaling molecules to a target tissue, and controlling the release of these factors and signaling molecules to spatially and temporally restrict their release and dissemination, for the purpose of promoting angiogenesis in target tissues wherein increased blood supply is needed.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: January 10, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Lan Cao, David J. Mooney
  • Publication number: 20160377952
    Abstract: An electro-optic assembly comprises an adhesive layer and a layer of electro-optic material. The adhesive layer comprises a polymeric adhesive material and an ionic material having either its cation or its anion fixed to the polymeric adhesive material. The ionic material reduces the volume resistivity of the polymeric adhesive material and is not removed upon heating to 50° C. In a similar electro-optic assembly comprising an adhesive layer and a layer of electro-optic material, the adhesive layer comprises a polymeric adhesive material which has been subjected to dialysis or diafiltration to remove organic species having a molecular weight less than about 3,500, so that the adhesive material has a content of N-methylpyrrolidone not exceeding 500 ppm based upon the total weight of the adhesive layer and layer of electro-optic material.
    Type: Application
    Filed: September 9, 2016
    Publication date: December 29, 2016
    Inventors: Thomas H. Whitesides, Lan Cao
  • Publication number: 20160355777
    Abstract: The present disclosure relates to systems and methods for flow-through separation of paramagnetic particle-bound cells in a cell suspension containing both bound and unbound cells as well as systems and methods for removing paramagnetic particles from paramagnetic particle-bound cells or from a cell suspension with unbound cells. It further relates to a flow-through magnetic separation/debeading module and a flow-through spinning membrane debeading module.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 8, 2016
    Inventors: Fabio Fachin, Rodney Rietze, Michael R. Greene, Lan Cao
  • Publication number: 20160189632
    Abstract: The invention provides materials and methods (including driving methods) for reducing the effects of remnant voltages in electro-optic displays.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 30, 2016
    Inventors: Russell J. Wilcox, Thomas H. Whitesides, Karl Raymond Amundson, Guy M. Danner, Richard M. Webber, Charles Howie Honeyman, Lan Cao, Richard J. Paolini, JR., Rajesh Chebiyam
  • Publication number: 20150283210
    Abstract: The present invention comprises compositions, methods, and devices for delivering angiogenic factors and signaling molecules to a target tissue, and controlling the release of these factors and signaling molecules to spatially and temporally restrict their release and dissemination, for the purpose of promoting angiogenesis in target tissues wherein increased blood supply is needed.
    Type: Application
    Filed: April 6, 2015
    Publication date: October 8, 2015
    Inventors: Lan Cao, David J. Mooney