Abstract: The present invention relates to a cocrystal of progesterone, which is formed by the active ingredient progesterone and a cocrystal former which is selected from isophthalic acid, 4-formylbenzeneboronic acid and 3-nitrophthalic acid. The present invention also relates to the method for preparing the cocrystal of progesterone and use thereof for increasing the thickness of endometrium, improving progesterone's solubility or increasing progesterone's permeation rate.

Abstract: The present invention relates to a cocrystal of progesterone, which is formed by the active ingredient progesterone and a cocrystal former which is selected from isophthalic acid, 4-formylbenzeneboronic acid and 3-nitrophthalic acid. The present invention also relates to the method for preparing the cocrystal of progesterone and use thereof for increasing the thickness of endometrium, improving progesterone's solubility or increasing progesterone's permeation rate.

Abstract: A ratchet wrench includes an annular head, a driving unit, a control unit, a rotary member, a second body, a bead and an end piece. The annular head receives the driving unit therein and a shaft extends from the annular head. The driving unit has a top part and a bottom part, between which a first toothed ring, a first pawl, two second pawls, a third pawl and a second toothed ring are pivotably located. The rotary member is rotatably inserted into an axial hole of the shaft and has third teeth, a recess and an engaging groove. The third teeth are engaged with the first and second toothed rings. A bead biased by a spring located in the shaft and is engaged with the engaging groove. The recess of the rotary member is connected with the second body.

Abstract: A ratchet wrench includes an annular head, a driving unit, a control unit, a rotary member, a second body, a bead and an end piece. The annular head receives the driving unit therein and a shaft extends from the annular head. The driving unit has a top part and a bottom part, between which a first toothed ring, a first pawl, two second pawls, a third pawl and a second toothed ring are pivotably located. The rotary member is rotatably inserted into an axial hole of the shaft and has third teeth, a recess and an engaging groove. The third teeth are engaged with the first and second toothed rings. A bead biased by a spring located in the shaft and is engaged with the engaging groove. The recess of the rotary member is connected with the second body.

Abstract: A wrench includes a body having a working end which has a first toothed portion, a first room, a second room, a third room and a first pivot cavity. The second and third rooms open through the top of the body. A driving unit is pivotably connected to the working end and has a first recess and a second recess for receiving a first pawl and a second pawl therein. The first pawl has teeth engaged with the first toothed portion, and the second pawl has teeth engaged with a second toothed portion of a first teeth disk in the first room. A second teeth disk is pivotably located in the second room and has a forth toothed portion which is engaged with a third toothed portion of the first teeth disk. A shaft is pivotably located in the third room and is connected to the second teeth disk.

Abstract: A wrench includes a body having a working end which has a first toothed portion, a first room, a second room, a third room and a first pivot cavity. The second and third rooms open through the top of the body. A driving unit is pivotably connected to the working end and has a first recess and a second recess for receiving a first pawl and a second pawl therein. The first pawl has teeth engaged with the first toothed portion, and the second pawl has teeth engaged with a second toothed portion of a first teeth disk in the first room. A second teeth disk is pivotably located in the second room and has a forth toothed portion which is engaged with a third toothed portion of the first teeth disk. A shaft is pivotably located in the third room and is connected to the second teeth disk.

Abstract: This invention relates to isolated nucleic acid and amino acid sequences of rat TRPM7 gene, expression cassettes nucleic acid sequences of rat TRPM7 gene, recombinant host cells comprising nucleic acid and amino acid sequences of rat TRPM7 gene, and methods of screening for modulators of the TRPM7 gene and protein.