Patents by Inventor Lan Ko
Lan Ko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240153814Abstract: Methods of forming a semiconductor device structure are described. In some embodiments, the method includes forming an interconnect structure over a substrate. The forming the interconnect structure over the semiconductor device structure includes forming a dielectric layer, then performing an annealing process, then forming one or more openings in the dielectric layer, then performing a first ultraviolet (UV) curing process, and then forming conductive features in the one or more openings.Type: ApplicationFiled: January 6, 2024Publication date: May 9, 2024Inventors: Yi-Wen PAN, You-Lan LI, Chung-Chi KO
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Patent number: 11940603Abstract: A narrow-profile lens group for long-distance image capture includes a first lens, a second lens, a third lens, a fourth lens, a fifth lens and a sixth lens, from object side to imaging side. Each lens has two surfaces, the group meeting formula 0.85<D/TTL<1.05, 0.37<(D*0.5)/F<0.45, where D is the maximum imaging circle diameter on the imaging surface; TTL is the distance from the center point of a surface of the first lens adjacent to the object side to the imaging surface, and F is the focal length of the telephoto lens.Type: GrantFiled: December 15, 2020Date of Patent: March 26, 2024Assignee: HON HAI PRECISION INDUSTRY CO., LTD.Inventors: Ya-Lan Feng, Chun-Cheng Ko
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Patent number: 11473149Abstract: It has been discovered that the human GT198 gene (gene symbol PSMC3IP) at chromosome 17q21 acts as a tumor suppressor. The mutation of the GT198 gene causes the increased dominant negative splice variant activity and leads to the loss of wild type GT198 function, and in turn, induces breast and ovarian cancers. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to the GT198 gene mutations. Another embodiment provides methods and compositions for detecting cancer due to the mutation of the GT198 gene. Still another embodiment provides methods for identifying compounds, antibodies and natural product molecules that are useful for treating cancer due to the mutations of the GT198 gene. Preferably the disclosed compositions antagonize or interfere with the biological activity of splice variants of GT198.Type: GrantFiled: August 20, 2019Date of Patent: October 18, 2022Inventor: Lan Ko
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Patent number: 11020594Abstract: The invention relates to an electrochemical dephosphorylation technique for treating Alzheimer's disease and a use thereof. It comprises a gold electrode provided with a negative potential of ?0.2 V to ?0.6 V on a surface thereof.Type: GrantFiled: June 14, 2019Date of Patent: June 1, 2021Assignee: National Chiao Tung UniversityInventors: Jung-Chih Chen, I-Chiu Li, Kun-Che Li, Ching-Cheng Chuang, Mei-Lan Ko, Hsin-Yu Chen, Chia-Hsuan Chang, Hsin-Yi Tsai, Chien-Chih Hsu
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Publication number: 20200391033Abstract: The invention relates to an electrochemical dephosphorylation technique for treating Alzheimer's disease and a use thereof. It comprises a gold electrode provided with a negative potential of ?0.2 V to ?0.6 V on a surface thereof.Type: ApplicationFiled: June 14, 2019Publication date: December 17, 2020Inventors: JUNG-CHIH CHEN, I-CHIU LI, KUN-CHE LI, CHING-CHENG CHUANG, MEI-LAN KO, HSIN-YU CHEN, CHIA-HSUAN CHANG, HSIN-YI TSAI, CHIEN-CHIH HSU
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Patent number: 10677805Abstract: The invention relates to color-changing eye drops for early screening Alzheimer's disease and an application thereof. The color-changing eye drop for early screening Alzheimer's disease comprises 1 pg/ml to 10 ng/ml of A?42 aptamer-gold nanoparticles (AuNPs) and a pharmaceutically acceptable carrier or vehicle thereof, which can be used to mix with a tear sample of a test subject to analyze a color change of the color-changing eye drop for determining the concentration proportion of A?40:A?42 contained in the tear sample of the test subject.Type: GrantFiled: June 14, 2019Date of Patent: June 9, 2020Assignee: NATIONAL CHIAO TUNG UNIVERSITYInventors: Jung-Chih Chen, I-Chiu Li, Kun-Che Li, Ching-Cheng Chuang, Mei-Lan Ko, Han-Chien Chuang, Ming-Hung Chien, Yu-Rong Wang, Hung-Ru Wang
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Publication number: 20200002774Abstract: It has been discovered that the human GT198 gene (gene symbol PSMC3IP) at chromosome 17q21 acts as a tumor suppressor. The mutation of the GT198 gene causes the increased dominant negative splice variant activity and leads to the loss of wild type GT198 function, and in turn, induces breast and ovarian cancers. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to the GT198 gene mutations. Another embodiment provides methods and compositions for detecting cancer due to the mutation of the GT198 gene. Still another embodiment provides methods for identifying compounds, antibodies and natural product molecules that are useful for treating cancer due to the mutations of the GT198 gene. Preferably the disclosed compositions antagonize or interfere with the biological activity of splice variants of GT198.Type: ApplicationFiled: August 20, 2019Publication date: January 2, 2020Inventor: LAN KO
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Patent number: 10443104Abstract: It has been discovered that the human GT198 gene (gene symbol PSMC3IP) at chromosome 17q21 acts as a tumor suppressor. The mutation of the GT198 gene causes the increased dominant negative splice variant activity and leads to the loss of wild type GT198 function, and in turn, induces breast and ovarian cancers. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to the GT198 gene mutations. Another embodiment provides methods and compositions for detecting cancer due to the mutation of the GT198 gene. Still another embodiment provides methods for identifying compounds, antibodies and natural product molecules that are useful for treating cancer due to the mutations of the GT198 gene. Preferably the disclosed compositions antagonize or interfere with the biological activity of splice variants of GT198.Type: GrantFiled: June 2, 2017Date of Patent: October 15, 2019Inventor: Lan Ko
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Publication number: 20170327900Abstract: It has been discovered that the human GT198 gene (gene symbol PSMC3IP) at chromosome 17q21 acts as a tumor suppressor. The mutation of the GT198 gene causes the increased dominant negative splice variant activity and leads to the loss of wild type GT198 function, and in turn, induces breast and ovarian cancers. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to the GT198 gene mutations. Another embodiment provides methods and compositions for detecting cancer due to the mutation of the GT198 gene. Still another embodiment provides methods for identifying compounds, antibodies and natural product molecules that are useful for treating cancer due to the mutations of the GT198 gene. Preferably the disclosed compositions antagonize or interfere with the biological activity of splice variants of GT198.Type: ApplicationFiled: June 2, 2017Publication date: November 16, 2017Inventor: LAN KO
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Patent number: 9738936Abstract: It has been discovered that the human GT198 gene (gene symbol PSMC3IP) at chromosome 17q21 acts as a tumor suppressor. The mutation of the GT198 gene causes the increased dominant negative splice variant activity and leads to the loss of wild type GT198 function, and in turn, induces breast and ovarian cancers. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to the GT198 gene mutations. Another embodiment provides methods and compositions for detecting cancer due to the mutation of the GT198 gene. Still another embodiment provides methods for identifying compounds, antibodies and natural product molecules that are useful for treating cancer due to the mutations of the GT198 gene. Preferably the disclosed compositions antagonize or interfere with the biological activity of splice variants of GT198.Type: GrantFiled: June 19, 2013Date of Patent: August 22, 2017Inventor: Lan Ko
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Patent number: 9574240Abstract: It has been discovered that amplifications in the gene coactivator activator (CoAA) blocks stem cell differentiation and induces cancer stem cells. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to gene amplifications in CoAA. Another embodiment provides methods and compositions for detecting cancer due to gene amplifications in CoAA. Still another embodiment provides methods for identifying compounds, antibodies and nucleic acid molecules that are useful for treating cancer due to gene amplifications in CoAA. Preferably the disclosed compositions antagonize or interfere with the CoAA amplicons and the biological activity of CoAA and or splice variants thereof.Type: GrantFiled: October 24, 2014Date of Patent: February 21, 2017Inventor: Lan Ko
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Publication number: 20160174837Abstract: A method for measuring two pupils includes a number of steps. A first visible light beam and a first invisible light beam are emitted toward a right eye. A second visible light beam and a second invisible light beam are emitted toward a left eye. The light beams reflected from the right eye and the left eye are received by an optical unit, and the first invisible light beam and the second invisible light beam are guided to an imaging unit by the optical unit. Images of the right eye and the left eye are respectively recorded through the first invisible light and the second invisible light beam propagated from the optical unit.Type: ApplicationFiled: April 14, 2015Publication date: June 23, 2016Inventors: Mang OU-YANG, Ting-Wei HUANG, Jin-Chern CHIOU, Mei-Lan KO, Bak-Sau YIP, Chih-Cheng WU, Wei-De JENG, Yin-Yuan CHEN, Bi-Shou SONE
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Publication number: 20150111209Abstract: It has been discovered that amplifications in the gene coactivator activator (CoAA) blocks stem cell differentiation and induces cancer stem cells. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to gene amplifications in CoAA. Another embodiment provides methods and compositions for detecting cancer due to gene amplifications in CoAA. Still another embodiment provides methods for identifying compounds, antibodies and nucleic acid molecules that are useful for treating cancer due to gene amplifications in CoAA. Preferably the disclosed compositions antagonize or interfere with the CoAA amplicons and the biological activity of CoAA and or splice variants thereof.Type: ApplicationFiled: October 24, 2014Publication date: April 23, 2015Inventor: Lan Ko
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Publication number: 20150098059Abstract: The present invention discloses a portable pupil detection device with multiband stimulating light and infrared illumination, which comprises at least one pupil detection module for detecting the variation of the pupil of the testee. Each pupil detection module includes an illuminating light source emitting invisible light beams; a stimulating light source emitting visible light beams; at least one beamsplitter corresponding to the illuminating light source, the stimulating light source and an eye of the testee, cooperating with the illuminating light source and the eye to form a first optical path, and cooperating with the stimulating light source and the eye to form a second optical path; a lens corresponding to the beamsplitter and receiving the invisible light beams sent out by the beamsplitter to form an image of the eye; and an imaging element receiving the image of the eye from the lens.Type: ApplicationFiled: February 27, 2014Publication date: April 9, 2015Applicants: NATIONAL TAIWAN UNIVERSITY HOPSITAL HSIN-CHU BRANCH, NATIONAL CHIAO TUNG UNIVERSITYInventors: MANG OU-YANG, JIN-CHERN CHIOU, MEI-LAN KO, TING-WEI HUANG, JYUN-WEI JHUANG, CHUN-CHENG HU
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Publication number: 20130273541Abstract: It has been discovered that the human GT198 gene (gene symbol PSMC3IP) at chromosome 17q21 acts as a tumor suppressor. The mutation of the GT198 gene causes the increased dominant negative splice variant activity and leads to the loss of wild type GT198 function, and in turn, induces breast and ovarian cancers. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to the GT198 gene mutations. Another embodiment provides methods and compositions for detecting cancer due to the mutation of the GT198 gene. Still another embodiment provides methods for identifying compounds, antibodies and natural product molecules that are useful for treating cancer due to the mutations of the GT198 gene. Preferably the disclosed compositions antagonize or interfere with the biological activity of splice variants of GT198.Type: ApplicationFiled: June 19, 2013Publication date: October 17, 2013Inventor: Lan Ko
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Publication number: 20100266588Abstract: It has been discovered that the human GT198 gene (gene symbol PSMC3IP) at chromosome 17q21 acts as a tumor suppressor. The mutation of the GT198 gene causes the increased dominant negative splice variant activity and leads to the loss of wild type GT198 function, and in turn, induces breast and ovarian cancers. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to the GT198 gene mutations. Another embodiment provides methods and compositions for detecting cancer due to the mutation of the GT198 gene. Still another embodiment provides methods for identifying compounds, antibodies and natural product molecules that are useful for treating cancer due to the mutations of the GT198 gene. Preferably the disclosed compositions antagonize or interfere with the biological activity of splice variants of GT198.Type: ApplicationFiled: April 20, 2010Publication date: October 21, 2010Inventor: Lan Ko
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Publication number: 20080241140Abstract: It has been discovered that amplifications in the gene coactivator activator (CoAA) blocks stem cell differentiation and induces cancer stem cells. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to gene amplifications in CoAA. Another embodiment provides methods and compositions for detecting cancer due to gene amplifications in CoAA. Still another embodiment provides methods for identifying compounds, antibodies and nucleic acid molecules that are useful for treating cancer due to gene amplifications in CoAA. Preferably the disclosed compositions antagonize or interfere with the CoAA amplicons and the biological activity of CoAA and or splice variants thereof.Type: ApplicationFiled: February 12, 2008Publication date: October 2, 2008Inventors: Lan Ko, Yang Sui Brooks