Patents by Inventor Lan Shen

Lan Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzoazepin-oxy-acetic acid derivatives as PPAR-delta agonists used for the increase of HDL-C, lower LDL-C and lower cholesterol
    Patent number: 8633184
    Abstract: The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cataract, cardiovascular diseases, Metabolic X Syndrome, hyper-LDL-cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and hypo-HDL-cholesterolemia), atherosclerosis, obesity, and other disorders related to lipid metabolism and energy homeostasis complications thereof, using compounds of the invention are also described.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: January 21, 2014
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Gee-Hong Kuo, Yan Zhang, Lan Shen, Songfeng Lu, Keith T. Demarest, Patricia Pelton
  • Substituted pyrroline kinase inhibitors
    Patent number: 7786135
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: August 31, 2010
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • Substituted pyrroline kinase inhibitors
    Patent number: 7781450
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: August 24, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL
    Publication number: 20100120748
    Abstract: The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cataract, cardiovascular diseases, Metabolic X Syndrome, hyper-LDL-cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and hypo-HDL-cholesterolemia), atherosclerosis, obesity, and other disorders related to lipid metabolism and energy homeostasis complications thereof, using compounds of the invention are also described.
    Type: Application
    Filed: January 19, 2010
    Publication date: May 13, 2010
    Inventors: Gee-Hong Kuo, Yan Zhang, Lan Shen, Songfeng Lu, Keith T. Demarest, Patricia Pelton
  • Substituted pyrroline kinase inhibitors
    Patent number: 7705015
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: April 27, 2010
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, David F. McComsey
  • Benzoazepin-oxy-acetic acid derivatives as PPAR-delta agonists used for the increase of HDL-C, lower LDL-C and lower cholesterol
    Patent number: 7678786
    Abstract: The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cataract, cardiovascular diseases, Metabolic X Syndrome, hyper-LDL-cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and hypo-HDL-cholesterolemia), atherosclerosis, obesity, and other disorders related to lipid metabolism and energy homeostasis complications thereof, using compounds of the invention are also described.
    Type: Grant
    Filed: April 17, 2007
    Date of Patent: March 16, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gee-Hong Kuo, Yan Zhang, Lan Shen, Songfeng Lu, Keith T. Demarest, Patricia Pelton
  • SUBSTITUTED PYRROLINE KINASE INHIBITORS
    Publication number: 20090181982
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: March 11, 2009
    Publication date: July 16, 2009
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • SUBSTITUTED PYRROLINE KINASE INHIBITORS
    Publication number: 20090176806
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: March 11, 2009
    Publication date: July 9, 2009
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS
    Publication number: 20090131489
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Application
    Filed: January 23, 2009
    Publication date: May 21, 2009
    Inventors: Gee-Hong KUO, Lan Shen, Aihua Wang, Yan Zhang
  • Substituted pyrroline kinase inhibitors
    Patent number: 7524858
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: April 28, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, David F. McComsey
  • 4-((Phenoxyalkyl)thio)-phenoxyacetic acids and analogs
    Patent number: 7498351
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Grant
    Filed: November 15, 2005
    Date of Patent: March 3, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Gee-Hong Kuo, Lan Shen, Aihua Wang, Yan Zhang
  • BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL
    Publication number: 20070244094
    Abstract: The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cataract, cardiovascular diseases, Metabolic X Syndrome, hyper-LDL-cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and hypo-HDL-cholesterolemia), atherosclerosis, obesity, and other disorders related to lipid metabolism and energy homeostasis complications thereof, using compounds of the invention are also described.
    Type: Application
    Filed: April 17, 2007
    Publication date: October 18, 2007
    Inventors: Gee-Hong Kuo, Yan Zhang, Lan Shen, Songfeng Lu, Keith T. Demarest, Patricia Peiton
  • Substituted pyrroline kinase inhibitors
    Patent number: 7125878
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: October 24, 2006
    Assignee: Janssen Pharmaceutica
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey
  • Substituted pyrroline kinase inhibitors
    Publication number: 20060205763
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 17, 2006
    Publication date: September 14, 2006
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce Conway, David McComsey
  • Substituted pyrroline kinase inhibitors
    Publication number: 20060205762
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 17, 2006
    Publication date: September 14, 2006
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce Conway, David McComsey
  • 4-((Phenoxyalkyl)thio)-phenoxyacetic acids and analogs
    Publication number: 20060074246
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Application
    Filed: November 15, 2005
    Publication date: April 6, 2006
    Inventors: Gee-Hong Kuo, Lan Shen, Aihua Wang, Yan Zhang
  • 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
    Patent number: 7015329
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: March 21, 2006
    Assignee: Janssen Pharmaceutica N. V.
    Inventors: Gee-Hong Kuo, Lan Shen, Aihua Wang, Yan Zhang
  • 4-((Phenoxyalkyl)thio)-phenoxyacetic acids and analogs
    Publication number: 20050096362
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Application
    Filed: October 28, 2004
    Publication date: May 5, 2005
    Inventors: Gee-Hong Kuo, Lan Shen, Aihua Wang, Yan Zhang
  • Macroheterocylic compounds useful as kinase inhibitors
    Patent number: 6828327
    Abstract: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: December 7, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Gee-Hong Kuo, Han-Cheng Zhang, Catherine Prouty, Alan DeAngelis, Peter Connolly, William V. Murray, Lan Shen, Bruce Conway, Keith Demarest, Chandra R. Shah, Bruce E. Maryanoff, Kimberly B. White
  • Substituted pyrroline kinase inhibitors
    Publication number: 20040006095
    Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
    Type: Application
    Filed: May 6, 2003
    Publication date: January 8, 2004
    Inventors: Han-Cheng Zhang, Gee-Hong Kuo, Bruce E. Maryanoff, Hong Ye, David O'Neill, Lan Shen, Keith Demarest, Bruce R. Conway, David F. McComsey