Abstract: A method for treating a neurodegenerative disease is provided. The method for treating a neurodegenerative disease includes administering, to a subject in need thereof, one or more of a small molecule glycogen synthase (GYS) inhibitor, an antisense oligonucleotide targeting glycogen synthase, an antibody-enzyme fusion compound targeting polyglucosan bodies (PGBs), or combinations thereof.

Abstract: A window screen is attached to a sliding sash and to the sill. Fixed to the screen are two or more vertical bands of coil spring material. Thus when the sash is closed the springs cause the screen to coil tightly. As the sash is raised, the screen is uncoiled so that it covers the opening but remains taut. The coil may be located at the middle of opening or at the top. A housing integral with the sash end of the screen or surrounding the spring coil protects the coil from weather and debris.

Abstract: A guide to align a cutting or routing tool along a straight line has a stationary support fixed relative to the work and has arm-like linkage between the support and a hand-held tool or instrument. A first end-member of the first parallelogram frame is pivoted to the stationary support, preferably in conjunction with an arcuate angle indicator. Pivoted to this first end-member is a first parallelogram frame consisting of a pair of equal, parallel, arm-members which are pivoted to a pair of tangent identical rollers of a diameter equal to the effective distance between pivot centers of the first end-member. Means, such as bands around the rollers, insure that they revolve in opposite directions the same amount and remain tangent as the first arms move in parallelism. Extending from the center of each roller is one of a second pair of equal, parallel arms of the second frame which are pivoted to a final end-member of the same effective length as the first and the common end-members.