Abstract: An embodiment of the invention relates to a method for diagnosing Lyme disease, comprising: isolating a diagnostic composition from a biological sample, wherein the biological sample is urine or another bodily fluid, the diagnostic composition comprising a biomarker attributable to Borrelia strains, bound or complexed to an affinity molecule that is bound or complexed to a filamentous material; and analyzing isolated diagnostic composition using a mass spectrometry, an immunoassay, a protein sequencing, or other analytical methods to detect presence of Borrelia-derived biomarkers.

Abstract: Embodiments relate to peptides that binds with molecules of programmed death protein-1 (PD-1) to form a complex that modulate release of an inflammatory cytokine from a cell. Peptides are PD-1 agonists used to treat an inflammatory disease.

Abstract: The present invention relates to a non-destructive method comprising placing a tissue sample on a porous matrix, centrifuging the tissue sample under a negative pressure, applying a vacuum on the tissue sample, and collecting extracted extracellular vesicles from the tissue sample. The method does not cause physical rupturing of the tissue sample and maintains integrity of the tissue sample for further histopathological analysis. Moreover, the invention also provides a method of inducing an immune response of a host by immune sensitization using harvested extracellular vesicles.

Abstract: In an embodiment, a method comprising: adding a composition comprising a photochromic dye to a sample having an opioid compound to form a reacted product; illuminating an electromagnetic ray having a wavelength between about 100 nm to about 600 nm on the photochromic dye; and detecting the opioid compound in the sample.

Abstract: A method and system for accelerating employee growth is disclosed. A growth track is created. The growth track is associated with one or more competencies. The growth track is associated with one or more track levels. The growth track is aligned with a job architecture. The job architecture includes a job function, a job type, and one or more job tracks. The one or more job levels are mapped to the one or more track levels. A growth area is created. The growth area relates to one or more competencies. A user interface is caused to be presented on a device of a user based on the user being associated with the job function and the job type. The user interface allows the user to share an update pertaining to a progress of the user within the growth area.

Abstract: One exemplary embodiment of a method of forming a wrapping web assembly includes the steps of: providing a substantially continuous web of a wrapping material; providing an elongate tape stock comprising an adhesive tape portion having a release surface, and a double sided adhesive tape portion releasably adhered to said release surface; feeding said substantially continuous web of a wrapping material past a laminating station to an accumulator spool adapted to spool said web about an axis transverse its substantially continuous direction; feeding said elongate tape stock to said laminating station and cutting the elongate tape stock into discrete tape assemblies; adhering said discrete tape assemblies substantially transversely in spaced relation on one surface of said web; and spooling said web to said accumulator spool whereby an exposed adhesive layer of the tape assembly adheres in the spool to the other surface of the web.

Abstract: There is provided a wrapping web (11) having transverse tape assemblies (12) released from a double sided release film (13) and cut to length. The tape assemblies (12) comprise a double sided adhesive tape portion (14) adhered to the baling web (11) and an adhesive tape laminate portion (15) having a release surface overlying the double sided adhesive tape portion (14). The exposed adhesive layer (17) of the adhesive tape (15) permanently adheres to the back surface (24) of the web (11) as it is rolled up. The wrapping web assembly (10) is deployed by unwinding from an accumulator spool into a baling assembly. As the web (11) unspools from the accumulator spool, peel forces are applied to the tape assembly (12) causing separation of the adhesive (14) and double sided adhesive (15) tape portions. This presents an exposed adhesive layer (20) whereby the web (11) can be closed over itself to close the wrapping of a product such as cotton.

Abstract: A double alternating frequency algorithm (DAFA) uses a high frequency carrier wave (>1 GHz) that lies above environmental noise and is capable of carrying large amounts of data, stacks a plurality of N frequency channels on the carrier wave (e.g., one channel for each transformer serviced by a substation) and changes the frequency of the carrier wave at each transformer to repeat the data for downstream and upstream propagation for providing broadband Internet over power lines. This approach will fulfill the promise of broadband Internet to the vast rural areas of the United States that do not have access to broadband Internet. Furthermore, this approach will provide another revenue source for utility companies to leverage the existing power distribution system.

Abstract: A microwave safe tray may be configured to provide a user with multiple surfaces on which to heat items. The tray may include a rectangular support surface including a plurality of flow orifices, the rectangular support surface configured to support items to be heated; and a plurality of legs extending substantially perpendicularly from the rectangular support tray. The microwave-safe tray may be configured to support a second microwave-safe tray in a stacked configuration.

Abstract: The present invention provides compounds of the formula (I) or a pharmaceutically acceptable salt thereof. Compounds of the invention are autotaxin inhibitors useful in the treatment of pain associated with osteoarthritis.

Abstract: A method of decontaminating a freight container comprising the steps of: a) placing a freight container on a support; b) using an enclosure to substantially enclose the container on the support; and c) applying heat so that hot air moves within the enclosure around at least upright ends, sides and a roof of the container to kill or substantially weaken undesired life forms on or immediately adjacent to the exterior of the container.

Abstract: The present invention provides compounds of the formula I, wherein X is a bond or CH2; Q is CH2 or O; L is selected from the group consisting of —OCH2— and —CH2O—; or a pharmaceutically acceptable salt thereof. Compounds of the invention are autotaxin inhibitors.

Abstract: The present invention provides compounds of the formula I, wherein X is a bond or CH2; Q is CH2 or O; L is selected from the group consisting of —OCH2— and —CH2O—; or a pharmaceutically acceptable salt thereof. Compounds of the invention are autotaxin inhibitors.

Abstract: The present invention provides compounds of the formula (I) or a pharmaceutically acceptable salt thereof. Compounds of the invention are autotaxin inhibitors useful in the treatment of pain associated with osteoarthritis.

Abstract: The present invention provides compounds of Formula I or a pharmaceutical salt thereof, where the variables for R1, R2, and R3 are as described herein; methods of treating a condition such as hypertriglyceridemia; and processes for preparing the compounds.

Abstract: The present invention provides compounds of the Formula I: wherein X is a bond or CH2; R is selected from the group consisting of R1 and R2 are each independently selected from the group consisting of CH and N; R3 is H or CH3; R4 is H or CH3; L is selected from the group consisting of —O(CH2)3—, —C(O)NH(CH2)2—, —CH2C(O)NH(CH2)2—, —(CH2)3N(C(O)CH3)CH2—, —(CH2)2N(C(O)CH3)CH2—, —(CH2)3NH—, (CH2)2OCH2—, —(CH2)4—, —(CH2)2NHCH2—, —(CH2)3O—, and —CH2O(CH2)2—; or a pharmaceutically acceptable salt thereof. Compounds of this invention are autotaxin inhibitors.

Abstract: The present invention provides compounds of Formula I or a pharmaceutical salt thereof, where the variables for R1, R2, and R3 are as described herein; methods of treating a condition such as hypertriglyceridemia; and processes for preparing the compounds.

Abstract: The present invention provides compounds of the Formula I: wherein X is a bond or CH2; R is selected from the group consisting of R1 and R2 are each independently selected from the group consisting of CH and N; R3 is H or CH3; R4 is H or CH3; L is selected from the group consisting of —O(CH2)3—, —C(O)NH(CH2)2—, —CH2C(O)NH(CH2)2—, —(CH2)3N(C(O)CH3)CH2—, —(CH2)2N(C(O)CH3)CH2—, —(CH2)3NH—, (CH2)2OCH2—, —(CH2)4—, —(CH2)2NHCH2—, —(CH2)3O—, and —CH2O(CH2)2—; or a pharmaceutically acceptable salt thereof. Compounds of this invention are autotaxin inhibitors.

Abstract: The present invention provides compounds of Formula below: and analogues thereof where the various substituent groups, R1, R2, R3, R4, R5 A, and X are described herein; or a pharmaceutical salt thereof; a method of treating a condition such as hypertriglyceridemia and a process for preparing the compounds.

Abstract: A method of decontaminating a freight container comprising the steps of: a) placing a freight container on a support; b) using an enclosure to substantially enclose the container on the support; and c) applying heat so that hot air moves within the enclosure around at least upright ends, sides and a roof of the container to kill or substantially weaken undesired life forms on or immediately adjacent to the exterior of the container.