Abstract: A system for assisting with a chest compression treatment being administered to a patient. In one aspect, the system for assisting with chest compression treatment includes at least one sensor configured to measure blood flow data, one or more processors, in communication with the at least one sensor, and an output device configured to provide the output indication to the rescuer. The one or more processors are configured to perform operations including receiving the blood flow data from the at least one sensor, based on the blood flow data, generating arterial blood flow data and venous blood flow data, providing an estimation of chest compression effectiveness based on the arterial blood flow data and the venous blood flow data, the estimation being based on at least one peak comparison of arterial blood flow and venous blood flow, and generating an output indication of the estimation of chest compression effectiveness.

Abstract: A system for assisting with a chest compression treatment being administered to a patient. In one aspect, the system for assisting with chest compression treatment includes at least one sensor configured to measure blood flow data, one or more processors, in communication with the at least one sensor, and an output device configured to provide the output indication to the rescuer. The one or more processors are configured to perform operations including receiving the blood flow data from the at least one sensor, based on the blood flow data, generating arterial blood flow data and venous blood flow data, providing an estimation of chest compression effectiveness based on the arterial blood flow data and the venous blood flow data, the estimation being based on at least one peak comparison of arterial blood flow and venous blood flow, and generating an output indication of the estimation of chest compression effectiveness.

Abstract: The present disclosure relates to compositions, methods of preparation of the compositions, and methods including administration of said compositions for the prevention of neurological damage associated with cerebral ischemia.

Abstract: A device for delivering chest compressions for performing cardiopulmonary resuscitation includes a compression assembly and chest contact pad that can be positioned over the thorax of a patient experiencing a cardiac arrest. The compression assembly is supported by a frame and one or more positioning mechanisms for moving the compression assembly relative to the patient's left ventricle. A controller causes the compression assembly to deliver a plurality of chest compressions to the patient. A blood flow monitor, such as a Doppler ultrasound monitor, is coupled with the patient's femoral or carotid artery to monitor the flow of arterial blood when chest compressions are delivered and to communicate blood flow parameter information to the controller. The controller causes the positioning mechanism to move the location where the compressions are delivered to optimize the blood flow parameters.

Abstract: The present disclosure relates to compositions, methods of preparation of the compositions, and methods including administration of said compositions for the prevention of neurological damage associated with cerebral ischemia.

Abstract: Devices and methods for blood flow enhancement and hemodynamic power monitoring are provided. A blood flow enhancement device includes a pump system configured to be coupled to a central vasculature of a subject during cardiopulmonary resuscitation (CPR). The pump system includes a pumping mechanism configured to increase forward blood flow generated during the CPR while substantially limiting backward blood flow generated during the CPR. The pumping mechanism being operated concurrently with the CPR. The hemodynamic power monitor is configured to control a chest compression device and an active valve.

Abstract: A system including a first sampling portion configured to sample inhalation gas made up of a first gaseous mixture, a second sampling portion configured to sample exhalation gas made up of a second gaseous mixture, a gas analyzer configured to measure gas concentrations, a switching valve that controls flow of the sampled inhalation gas and the sampled exhalation gas to the gas analyzer so as to alternately measure concentration of gaseous components within the first and second gaseous mixtures, a humidity control system that maintains humidity within the first and second gaseous mixtures to a predetermined humidity level, and a calculation section configured to calculate concentration differences of the gaseous components between the first and second gaseous mixtures.

Abstract: Devices and methods for blood flow enhancement and hemodynamic power monitoring are provided. A blood flow enhancement device includes a pump system configured to be coupled to a central vasculature of a subject during cardiopulmonary resuscitation (CPR). The pump system includes a pumping mechanism configured to increase forward blood flow generated during the CPR while substantially limiting backward blood flow generated during the CPR. The pumping mechanism being operated concurrently with the CPR. The hemodynamic power monitor is configured to control a chest compression device and an active valve.

Abstract: The present invention is a vessel detector comprising a sensor, a display and an access device for positioning the sensor in a detection area. According to the invention the sensor device is an impedance sensor. The invention comprises also a method for locating vessels comprising impedance measuring.

Abstract: Provided are methods of reducing cell death, attenuating a burst of reactive oxygen species, reducing cytotoxicity, reducing intracellular oxidant stress due species in a population of cells following hypoxia by reoxygenating the cells in the presence of a reversible electron transport chain inhibitor or under hypercarbic conditions. Also provided is a method to determine the effectiveness of a reversible electron transport chain inhibitor for reducing cell death in a population of cells.

Abstract: Various systems for delivering phase-change particulate ice slurries to targeted areas or organs of a patient are provided. Systems for delivering phase-change particulate ice slurries include a slurry reservoir and a conduit for delivering slurry from the reservoir to the patient. The conduit may include multiple components, including a section of medical tubing, an insertion tip for directing the out flow of slurry to the targeted area, and one or more transition fittings to adapt the tubing to the insertion tip. Interfaces between the various components that form the slurry flow path are configured so that there are no sudden reductions in the cross sectional area of the flow path. Any narrowing of the flow path occurs in a gradual tapered manner. The entire flow path remains substantially free of all obstacles that may tend to trap particles and lead to plugging of the flow path.

Abstract: Methods of inducing protective hypothermia of an organ are described that include delivering a phase-change particulate slurry to at least a portion of the organ; and reducing a temperature of the organ through heat exchange with the phase-change particulate slurry. Therapeutically acceptable duration of artificially-induced ischemia of the organ is prolonged.

Abstract: Systems for phase-change particulate slurry cooling equipment and methods to induce hypothermia in a patient through internal and external cooling are provided. Subcutaneous, intravascular, intraperitoneal, gastrointestinal, and lung methods of cooling are carried out using saline ice slurries or other phase-change slurries compatible with human tissue. Perfluorocarbon slurries or other slurry types compatible with human tissue are used for pulmonary cooling. And traditional external cooling methods are improved by utilizing phase-change slurry materials in cooling caps and torso blankets.

Abstract: A wristwatch is set by optically transmitting time of day information from a wall clock or table clock to an optical sensor in the wristwatch. The time information is optically transmitted as sequential light pulses by controlling a light source, such as a light emitting diode (LED) in the wall clock or table clock.