Patents by Inventor Lance C. Kam

Lance C. Kam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for improving expansion of T cells from patients
    Patent number: 11760973
    Abstract: In an aspect, compositions, methods, and devices described herein provide a safer platform for the ex vivo expansion of cells for immunotherapeutic purposes that eradicates the possibility of having activating substrate transferred into the patient while maintaining and improving upon the level of cell activation and proliferation.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: September 19, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Alex Dang, Lance C. Kam
  • Activation and Expansion of T Cell Subsets Using Biocompatible Solid Substrates with Tunable Rigidity
    Publication number: 20230137331
    Abstract: The present invention provides compositions and methods for activation and expansion of T cells using a biocompatible solid substrate with tunable rigidity. Rigidity of a substrate is an important parameter that can be used to control the overall expansion and differentiation of T cells.
    Type: Application
    Filed: June 13, 2022
    Publication date: May 4, 2023
    Inventors: Michael C. Milone, Lance C. Kam, Keyue Shen, Xueli Hao, Roderick O'Connor, Geraldine Goebrecht
  • Methods, compositions, and systems for activation and expansion of cells
    Patent number: 10301590
    Abstract: The disclosure provides for compositions, systems, and methods of cell expansion, stimulation and/or differentiation. The disclosure further provides for a mesh substrate and associated methods capable of stimulating cell expansion, for example, T cell or stem cell expansion. In another aspect, the disclosure provides for an electrospun mesh substrate and methods of using thereof comprising a silicone rubber composition, for example, polydimethylsiloxane, PLC, or combinations thereof.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: May 28, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Lance C. Kam, Helen H. Lu, Sarah E. De Leo, Keenan T. Bashour, Danielle Bogdanowicz, Philip Chuang
  • METHOD FOR IMPROVING EXPANSION OF T CELLS FROM PATIENTS
    Publication number: 20190127686
    Abstract: In an aspect, compositions, methods, and devices described herein provide a safer platform for the ex vivo expansion of cells for immunotherapeutic purposes that eradicates the possibility of having activating substrate transferred into the patient while maintaining and improving upon the level of cell activation and proliferation.
    Type: Application
    Filed: May 3, 2017
    Publication date: May 2, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Alex DANG, Lance C. KAM
  • Methods, Compositions, and Systems for Activation and Expansion of Cells
    Publication number: 20170029767
    Abstract: The disclosure provides for compositions, systems, and methods of cell expansion, stimulation and/or differentiation. The disclosure further provides for a mesh substrate and associated methods capable of stimulating cell expansion, for example, T cell or stem cell expansion. In another aspect, the disclosure provides for an electrospun mesh substrate and methods of using thereof comprising a silicone rubber composition, for example, polydimethylsiloxane, PLC, or combinations thereof.
    Type: Application
    Filed: April 10, 2015
    Publication date: February 2, 2017
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Lance C. KAM, Helen H. LU, Sarah E. DE LEO, Keenan T. BASHOUR, Danielle BOGDANOWICZ, Philip CHUANG
  • Activation and Expansion of T Cell Subsets Using Biocompatible Solid Substrates with Tunable Rigidity
    Publication number: 20150030619
    Abstract: The present invention provides compositions and methods for activation and expansion of T cells using a biocompatible solid substrate with tunable rigidity. Rigidity of a substrate is an important parameter that can be used to control the overall expansion and differentiation of T cells.
    Type: Application
    Filed: September 6, 2012
    Publication date: January 29, 2015
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Michael C. Milone, Lance C. Kam, Keyue Shen, Hueli Hao, Roderick O'Connor, Geraldine Goebrecht