Abstract: Compositions and methods are disclosed for identifying patients for treatment of hematological malignancy.

Abstract: A flexible hose or a tubing having a barrier layer of polyamide 6 having an impact modifier, and/or branched molecular structure, a flexural modulus of 1 to 2 GPa and/or a tensile elongation of 100% or more. The hose may have additional layers such as an HNBR rubber inner tube, an EVM/CPE rubber blend outer cover, a textile or wire reinforcement, or the like. Permeability to ethanol- and methanol-containing fuels is very low. Permeability to B20 biofuels is very low.

Abstract: A flexible hose or a tubing having a barrier layer of polyamide 6 having an impact modifier, and/or branched molecular structure, a flexural modulus of 1 to 2 GPa and/or a tensile elongation of 100% or more. The hose may have additional layers such as an HNBR rubber inner tube, an EVM/CPE rubber blend outer cover, a textile or wire reinforcement, or the like. Permeability to ethanol- and methanol-containing fuels is very low. Permeability to B20 biofuels is very low.

Abstract: A flexible hose or a tubing having a barrier layer of polyamide 6 having an impact modifier, and/or branched molecular structure, a flexural modulus of 1 to 2 GPa and/or a tensile elongation of 100% or more. The hose may have additional layers such as an HNBR rubber inner tube, an EVM/CPE rubber blend outer cover, a textile or wire reinforcement, or the like. Permeability to ethanol- and methanol-containing fuels is very low. Permeability to B20 biofuels is very low.

Abstract: We describe a method of assigning a grade to a breast tumour, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of a gene selected from the genes set out in Table D0 (6g-TAGs) or Table D1 (SWS Classifier 0). We also describe methods of treating patients having a high aggressiveness tumour or a low aggressiveness tumour, by identifying the aggressiveness tumour by obtaining, from a sample of a histological Grade 2 tumour isolated from the patient, gene expression data of BRRN1, AURKA, MELK, PRR11, CENPW and E2F1; assigning a grade to the tumour by applying a class prediction algorithm to the gene expression data, wherein a Grade 3 tumour is classified as a high aggressiveness tumour and a Grade 1 tumour is classified as a low aggressiveness tumour; and specifically treating the patient accordingly.

Abstract: Compositions and methods useful for diagnosis and prognosis of cancer are provided.

Abstract: We describe a method of assigning a grade to a breast tumour, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of a gene selected from the genes set out in Table D1 (SWS Classifier 0).

Abstract: The present invention provides methods, systems and compositions for predicting disease susceptibility in a patient. In some embodiments, methods for the classification, prognosis, and diagnosis of cancers are provided. In other embodiments, the present invention provides statistical methods for building a gene-expression-based classifier that may be employed for predicting disease susceptibility in a patient, for classifying carcinomas, and for the prognosis of clinical outcomes.

Abstract: The present invention relates to methods of controlling tumorigenesis, including preventing, inhibiting, arresting or reversing tumorigenesis. The present invention also provides methods of treatment, prevention and diagnosis of neoblastoma, including cancer, such as metastatic cancer. In one method one or more cells having a predisposition to turn tumorigenic are identifyied. In the one or more cells an altered amount, an altered subcellular localisation or an altered activity of a Rab binding protein is detected. In a method of diagnosing the risk of developing a neoplasmt at least one of the expression level, the activity level and the subcellular localisation of a Rab binding protein is determined. In an in-vitro method of identifying a compound capable of forming a complex with a Rab binding protein the components that form the respective complex are contacted with each other.

Abstract: A hose coupling for fitment to an end of a cable reinforced hose includes a unitary stem having a cable trap groove portion having an outside diameter greater than an inside diameter of a tube of the hose and less than an inside diameter of the hose with the tube skived from the hose. A unitary ferrule defines at least one cable trap rib corresponding to the cable trap groove and having an inside diameter less than the outside diameter of the cable reinforced hose and greater than an outside diameter of the hose with material covering the cable skived from the hose. The groove width is at least the width of the rib plus twice the diameter of cable reinforcing the hose. Epoxy may be disposed between the hose tube and the stem for sealing or injected between the ferrule and the stem permeating the cable.

Abstract: A hose coupling for fitment to an end of a cable reinforced hose includes a unitary stem having a cable trap groove portion having an outside diameter greater than an inside diameter of a tube of the hose and less than an inside diameter of the hose with the tube skived from the hose. A unitary ferrule defines at least one cable trap rib corresponding to the cable trap groove and having an inside diameter less than the outside diameter of the cable reinforced hose and greater than an outside diameter of the hose with material covering the cable skived from the hose. The groove width is at least the width of the rib plus twice the diameter of cable reinforcing the hose. Epoxy may be disposed between the hose tube and the stem for sealing or injected between the ferrule and the stem permeating the cable.

Abstract: Compositions and methods useful for diagnosis and prognosis of cancer are provided.

Abstract: The present invention relates to methods of controlling tumorigenesis, including preventing, inhibiting, arresting or reversing tumorigenesis. The present invention also provides methods of treatment, prevention and diagnosis of neoblastoma, including cancer, such as metastatic cancer. In one method one or more cells having a predisposition to turn tumorigenic are identifyied. In the one or more cells an altered amount, an altered subcellular localisation or an altered activity of a Rab binding protein is detected. In a method of diagnosing the risk of developing a neoplasmt at least one of the expression level, the activity level and the subcellular localisation of a Rab binding protein is determined. In an in-vitro method of identifying a compound capable of forming a complex with a Rab binding protein the components that form the respective complex are contacted with each other.

Abstract: A multi-layer flexible hose with at least one vulcanized elastomer layer and an outermost cover layer of a thermoplastic polyurethane strip that is wrapped and thermally fused to form a continuous layer. The wrapping may be helical or longitudinal. The polyurethane includes a high hardness, a softening point at or below the vulcanization temperature, and an intumescent flame retarding additive stable at the vulcanization temperature. The polyurethane cover adheres to the elastomer layer and contributes to the flame resistance required by API 16D or of Lloyd's Register Fire Tests for Flexible Hoses on Offshore Installations OD/1000/499 rev. 1.

Abstract: A method is proposed identification of pairs of genes for which the respective gene expression values in a subject are statistically significant in relation to a medical condition, for example cancer, or more particularly breast cancer. Many pairs of genes are generated, and for each pair of genes clinical data is used to fit a statistical model to obtain the statistical significance of the ratio of the corresponding expression values. The clinical data characterizes for each of the patients the level of expressions of the genes and times until a clinical endpoint of interest.

Abstract: A hose coupling for fitment to an end of a cable reinforced hose comprises a unitary stem having a cable trap groove portion having an outside diameter greater than an inside diameter of a tube of the hose and less than an inside diameter of the hose with the tube skived from the hose. A unitary ferrule defines at least one cable trap rib corresponding to the cable trap groove and having an inside diameter less than the outside diameter of the cable reinforced hose and greater than an outside diameter of the hose with material covering the cable skived from the hose. The groove width is at least the width of the rib plus twice the diameter of cable reinforcing the hose. Epoxy may be disposed between the hose tube and the stem for sealing or injected between the ferrule and the stem permeating the cable.

Abstract: The present invention provides methods, systems and compositions for predicting disease susceptibility in a patient. In some embodiments, methods for the classification, prognosis, and diagnosis of cancers are provided. In other embodiments, the present invention provides statistical methods for building a gene-expression-based classifier that may be employed for predicting disease susceptibility in a patient, for classifying carcinomas, and for the prognosis of clinical outcomes.

Abstract: We describe a method of assigning a grade to a breast tumour, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of a gene selected from the genes set out in Table D1 (SWS Classifier 0).

Abstract: The present invention provides methods, systems and compositions for predicting disease susceptibility in a patient. In some embodiments, methods for the classification, prognosis, and diagnosis of cancers are provided. In other embodiments, the present invention provides statistical methods for building a gene-expression-based classifier that may be employed for predicting disease susceptibility in a patient, for classifying carcinomas, and for the prognosis of clinical outcomes.

Abstract: A flexible hose having a non-fluorinated rubber inner tube, a non-fluorinated rubber outer cover, an intermediate barrier layer consisting essentially of ethylene-vinyl alcohol copolymer (EVOH) having an ethylene content less than 30 mole %, and preferably a textile reinforcement between said barrier layer and said outer cover. A non-fluorinated rubber tie layer may be included between the barrier and the reinforcement. Permeability to ethanol- and methanol-containing fuels is very low.