Patents by Inventor Lance Davidow

Lance Davidow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
    Patent number: 11891625
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: February 6, 2024
    Inventors: Derrick J. Rossi, Wataru Ebina, Morag Stewart, Paula Gutierrez-Martinez, Lee L Rubin, Lance Davidow
  • METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE
    Publication number: 20200248143
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Application
    Filed: April 21, 2020
    Publication date: August 6, 2020
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. ROSSI, Wataru EBINA, Morag STEWART, Paula GUTIERREZ-MARTINEZ, Lee L. RUBIN, Lance DAVIDOW
  • Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
    Patent number: 10669528
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 2, 2020
    Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. Rossi, Wataru Ebina, Morag Stewart, Paula Gutierrez-Martinez, Lee L. Rubin, Lance Davidow
  • METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE
    Publication number: 20180187156
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Application
    Filed: June 24, 2016
    Publication date: July 5, 2018
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. ROSSI, Wataru EBINA, Morag STEWART, Paula GUTIERREZ-MARTINEZ, Lee RUBIN, Lance DAVIDOW
  • COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS
    Publication number: 20160264939
    Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
    Type: Application
    Filed: October 13, 2015
    Publication date: September 15, 2016
    Inventors: Shuibing C. Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo Fox, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin
  • Compositions and methods for promoting the generation of PDX1+ pancreatic cells
    Patent number: 9157062
    Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: October 13, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Shuibing C. Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo Fox, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L Rubin
  • COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS
    Publication number: 20140335611
    Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
    Type: Application
    Filed: May 20, 2014
    Publication date: November 13, 2014
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Shuibing C. Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin
  • Compositions and methods for promoting the generation of PDX1+ pancreatic cells
    Patent number: 8728812
    Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: May 20, 2014
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Shuibing Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin
  • COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS
    Publication number: 20110070645
    Abstract: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.
    Type: Application
    Filed: April 22, 2009
    Publication date: March 24, 2011
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Shuibing Chen, Douglas A. Melton, Malgorzata Borowiak, Julia Lamenzo, Stuart L. Schreiber, Lee F. Peng, Lance Davidow, Kelvin Lam, Lee L. Rubin