Abstract: A system that provides an antimicrobial, dermal defense for hand-mediated functions. The system includes microbicidal towelettes and dispensers for towelette delivery near dermal microbial sources. More specifically, the system includes towelettes impregnated with a specific antimicrobial composition and a dispenser unit containing the towelettes positioned next to a microbe-containing source; and may be used in conjunction with a refuse container for disposal of the towelettes. The user grasps the towelette from the dispenser unit, positions the towelette as a barrier between the user's hand and the microbe-contaminated source, grasps the microbe-contaminated source with the towelette, and properly disposes of the towelette after use.