Abstract: The invention relates to a relates to a highly sensitive, non-invasive diagnostic method for detection infectious diseases. In one embodiment, the invention relates to novel rapid, self-working, visual field test for a panel of disease specific derived biomarkers. In one embodiment, the invention comprises a collecting device comprising a collapsible non hygroscopic net tethered with immobilized nanoparticles to capture and concentrate a target analyte present in a fluid; wherein the nanoparticle comprises a core and a shell, wherein the core comprises a molecular bait. The invention also relates to identification of biomarkers for identification of various pathogenic diseases.

Abstract: In an embodiment, a method comprising: adding a composition comprising a photochromic dye to a sample having an opioid compound to form a reacted product; illuminating an electromagnetic ray having a wavelength between about 100 nm to about 600 nm on the photochromic dye; and detecting the opioid compound in the sample.

Abstract: This invention relates to JAK selective inhibitors for use in treatment of chronic neutrophilic leukemia and atypical chronic myeloid leukemia in patients.

Abstract: This invention relates to JAK selective inhibitors for use in treatment of chronic neutrophilic leukemia and atypical chronic myeloid leukemia in patients.

Abstract: This invention relates to spirocyclic piperidines according to Formula (I) and the use of spirocyclic piperidines for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of spirocyclic piperidines in the treatment of cancer.

Abstract: This invention relates to spirocyclic piperidines according to Formula (I) and the use of spirocyclic piperidines for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of spirocyclic piperidines in the treatment of cancer.

Abstract: This invention relates to the use of spirocyclic piperidine derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of spirocyclic piperidines in the treatment of cancer.

Abstract: A utility knife with a folding mechanism is provided, and the knife comprises: a handle comprising at least two side walls forming an internal space; a blade holding compartment having at least one end pivotally connected to the handle, the blade holding compartment comprises at least two side walls forming an internal blade cavity for holding a blade, the blade holding compartment comprises at least one notch, at least a portion of the blade holding compartment is designed to be situated within the space of the handle during a folded position; and a folding lock and release device comprises at least one spring and at least one slideably movable locking mechanism, and the mechanism comprises at least one protrusion and at least one button for controlling movement of the mechanism, and the protrusion engaging the notch and the spring being in an extended position during an open, unfolded position, and the button is slideably moved in one direction to compress the spring and to disengage the protrusion from the

Abstract: A communications patching system includes first and second patch panels, each having a plurality of connector ports, and a patch cord that is configured to selectively interconnect a connector port in the first patch panel with a connector port in the second patch panel. Each patch panel includes a port identification circuit that is electrically coupled with the connector ports of the respective patch panel. The port identification circuit of each patch panel is configured to transmit a signal to a connector port of the other patch panel over a common mode transmission path of the patch cord. The first and second connector ports connected by the patch cord are identified from the signal path.