Abstract: The invention presents a novel feed formulation and processing optimized for horseshoe crabs in prolonged captivity, with application to myriad species. The formulation is not only sustainable but environmentally advantageous at scale by utilizing fish and poultry processing by-products. The nutrient-rich waste products are enhanced through cold-processed, enzymatic liquefication and fermentation, which preserves proteins and vitamins and thus, nutrient integrity and bioavailability. The formulation is matched to the composition of the horseshoe crab and the flora and fauna of its habitat diet. Feed efficacy can be measured by observed attraction and palatability, as well as parameters including but not limited to cellular integrity and amebocyte reactivity, weight, disease resistance, and carapace metrics.

Abstract: This invention relates to a broad-spectrum antimicrobial marine biologic composition for bloodstream infections, derived from smeLAL and optional hemolymph of sustainable aquaculture horseshoe crabs. The formulation serves as an injectable treatment with broad-spectrum antimicrobial activity and an array of therapeutic mechanisms. In one embodiment, subject to clinical studies and characterization of cross-species immunogenicity, the composition may act as a breakthrough antimicrobial—or as a last-resort therapy for critically ill sepsis patients. In an alternative embodiment, the biologically derived antimicrobial agent represents a viable primary therapy with advantages over synthetic antibiotics, including a rapid therapeutic window. Given unmatched efficacy, an adjuvant smeLAL immunoglobulin therapy may be warranted to allow routine use if needed to address cross-species immunogenicity.

Abstract: A flight simulator rests on a plurality of air cushions as a hovercraft and assumes spatial attitudes depending upon the relative heights of the air cushions. Flight controls determine the volume of air supplied to each air cushion and thereby control the pitch and roll attitudes of the flight simulator. The simulator may be connected to an external support frame and may thereby be subjected to longitudinal, lateral, and rotational movements.

Abstract: A flight simulator rests on a plurality of air cushions as a hovercraft and assumes spatial attitudes depending upon the relative heights of the air cushions. Flight controls determine the volume of air supplied to each air cushion and thereby control the pitch and roll attitudes of the flight simulator. The simulator may be connected to an external support frame and may thereby be subjected to longitudinal, lateral, and rotational movements.