Abstract: Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including a head mounted display to monitor one or more physiologic signals from the face or head of the subject is disclosed. A method for analyzing an ocular parameter of the subject to determine a sympathetic and a parasympathetic outflow thereto is disclosed.

Abstract: A method includes forming a film, forming a first pattern of two or more vias at least partially through the film, attaching the film to a first support structure, the first support structure comprising an adhesive layer formed over a first carrier, wherein attaching the film to the first support structure comprises bonding a first surface of the film to the adhesive layer of the first support structure, wherein the film is stretchable in at least a first direction along the first surface, and wherein the first carrier maintains the first pattern of vias within a given threshold distortion following a given process conducted after attaching the film to the first support structure.

Abstract: A system for modulating bladder function is disclosed. A system for evaluating the electrophysiological function of a bladder is disclosed. Methods for performing a controlled surgical procedure on a bladder are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. An implantable device for monitoring and/or performing a neuromodulation procedure on a bladder is disclosed.

Abstract: Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including patches and corresponding modules for wirelessly monitoring physiologic and/or physical signals is disclosed. A service system for managing the collection of physiologic data from a customer is disclosed. An isolating patch for providing a barrier between a handheld monitoring device with a plurality of contact pads and a subject is disclosed.

Abstract: A medical device comprises a control system, processing modules, and a wire bundle connecting the control system to the processing modules, the wire bundle comprising control lines and data lines. Each processing module is coupled to a respective set of sensors arranged to interface with a biological tissue site, the sensors being configured to capture analog physiological signals generated from the biological tissue site. The control system is configured to generate a control signal on the control lines to initiate a data collection cycle by the processing modules. In response to the control signal, each processing module is configured to perform a respective data collection process which comprises (i) capturing and processing an analog physiological signal on each enabled sensor to generate a data sample for each analog physiological signal captured on each enabled sensor, and (ii) outputting data samples to the control system on the data lines.

Abstract: A method includes receiving monitoring data from at least one sensing device coupled to a subject and analyzing the monitoring data to identify one or more physiologic parameters of the subject. The method also includes providing signaling to at least one stimulating device in response to the identified physiologic parameters, the signaling comprising instructions to apply a stimulus to the subject. The method further includes receiving additional monitoring data from the at least one sensing device, analyzing the additional monitoring data to identify one or more changes in the one or more physiologic parameters of the subject after application of the stimulus to the subject, and providing additional signaling to the at least one stimulating device, the additional signaling comprising instructions to modify the stimulus applied to the subject based on the identified changes in the one or more physiologic parameters.

Abstract: A system includes a control unit configured to be worn by a subject including one or more processors operatively coupled to a memory, a wireless transceiver, and a power supply for powering the one or more processors. The system also includes a computing device independent of the control unit including one or more processors operatively coupled to a memory, a wireless transceiver in communication with the wireless transceiver of the control unit, and a display. The system further includes at least one primary sensor and at least one secondary sensor mountable relative to the subject configured to generate respective primary and secondary signals and to communicate the primary and secondary signals to one of the control unit and the computing device.

Abstract: A method includes obtaining monitoring data recorded by first and second devices, the first and second devices being attached to the subject at different first and second sties, respectively. The monitoring data comprises signals associated with at least one physiological parameter of the subject. The method also includes extracting one or more features of the signals recorded by the first and second devices during a transitionary period when the first and second devices simultaneously monitor the at least one physiological parameter of the subject. The method further includes generating at least one correlation parameter by analyzing the extracted features of the signals recorded by the first and second devices for at least a portion of the transitionary period, the at least one correlation parameter when applied to signals recorded by the second device at least partially compensating for relative changes in signals recorded by the first and second devices.

Abstract: Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including a head mounted display to monitor one or more physiologic signals from the face or head of the subject is disclosed. A method for analyzing an ocular parameter of the subject to determine a sympathetic and a parasympathetic outflow thereto is disclosed.

Abstract: A method includes forming a film, forming a first pattern of two or more vias at least partially through the film, attaching the film to a first support structure, the first support structure comprising an adhesive layer formed over a first carrier, wherein attaching the film to the first support structure comprises bonding a first surface of the film to the adhesive layer of the first support structure, wherein the film is stretchable in at least a first direction along the first surface, and wherein the first carrier maintains the first pattern of vias within a given threshold distortion following a given process conducted after attaching the film to the first support structure.

Abstract: A medical device comprises a control system, processing modules, and a wire bundle connecting the control system to the processing modules, the wire bundle comprising control lines and data lines. Each processing module is coupled to a respective set of sensors arranged to interface with a biological tissue site, the sensors being configured to capture analog physiological signals generated from the biological tissue site. The control system is configured to generate a control signal on the control lines to initiate a data collection cycle by the processing modules. In response to the control signal, each processing module is configured to perform a respective data collection process which comprises (i) capturing and processing an analog physiological signal on each enabled sensor to generate a data sample for each analog physiological signal captured on each enabled sensor, and (ii) outputting data samples to the control system on the data lines.

Abstract: A system includes a control unit configured to be worn by a subject, and having a wireless transceiver configured to receive and transmit signals and a processor coupled to a memory, at least one respiratory volume sensor mountable to the chest or abdomen of the subject and at least one secondary sensor mountable relative to the subject. The respiratory volume sensor is configured to operably generate one or more volumetric signals representative of a respiratory volume of the subject and communicate the one or more volumetric signals to the wireless transceiver of the control unit. The at least one secondary sensor is configured to operably generate one or more secondary signals and representative of at least one of a physiological, a cardiopulmonary or a metabolic condition of the subject, and communicate the one or more secondary signals to the wireless transceiver of the control unit.

Abstract: An apparatus comprises at least one processing device configured to generate a model of an outbreak of a disease based on physiological monitoring and location data received from wearable devices of a plurality of users, to determine a first subset of the plurality of users that have potentially contracted the disease based on a comparison of the physiological monitoring data and known symptoms of the disease, to identify a second subset of the plurality of users that are at risk for contracting the disease from the first subset of the plurality of users utilizing the model of the outbreak of the disease and the location data, and to generate notifications for delivery to the plurality of users comprising information related to outbreak of the disease and measures for at least one of treating and mitigating spread of the disease.

Abstract: An apparatus comprises a processing device configured to receive health data characterizing outbreak of a disease and physiological monitoring data from wearable devices associated with users and to calculate user-specific risks of at least one of contracting and spreading the disease based on analysis of the physiological monitoring data and the health data characterizing the outbreak of the disease. The processing device is also configured to generate notifications for delivery to the users based on the user-specific risks, the notifications comprising information related to outbreak of the disease and measures for treating and mitigating spread of the disease. The processing device is further configured to modify at least a given one of the notifications to be delivered to the given user based at least in part on identifying that the given user is associated with at least one of the first responder network and the local caregiver network.

Abstract: An apparatus comprises a processing device configured to receive physiological monitoring data from wearable devices, to generate telemedicine data based on telemedicine interactions between a given user and telemedical support staff of a telemedicine network, and to calculate, for the given user, a predicted outcome and associated user-specific risk of contracting and spreading a disease for two or more telemedical treatment scenarios based on the physiological monitoring data and the telemedicine data. The processing device is also configured to recommend a given telemedical treatment scenario for the given user based on the predicted outcomes and associated user-specific risks for the telemedical treatment scenarios, and to generate notifications for delivery to at least one of the given user and one or more other users based on the recommended telemedical treatment scenario, the notifications comprising information related to outbreak of and measures for treating and mitigating spread of the disease.

Abstract: A gateway device comprises a processing device, network interface, and sensor device interconnect. The processing device is configured to pair sensor devices associated with a subject with the gateway device utilizing the sensor device interconnect, wherein pairing the sensor devices comprises identifying sensing capabilities of the sensor devices. The processing device is also configured to provide, to a study coordinating system over a first network connection established utilizing the network interface, a gateway identifier and information characterizing the identified sensing capabilities of the sensor devices paired with the gateway device.

Abstract: Systems and methods for controlled sympathectomy procedures for neuromodulation are disclosed. A system for controlled micro ablation procedures is disclosed. A guidewire including one or more sensors or electrodes for accessing and recording physiologic information from one or more anatomical sites within the parenchyma of an organ as part of a physiologic monitoring session, a diagnostic test, or a neuromodulation procedure is disclosed. A guidewire including one or more sensors and/or a means for energy delivery, for performing a neuromodulation procedure within a small vessel within a body is disclosed.

Abstract: An apparatus comprises at least one processing device comprising a processor coupled to a memory. The at least one processing device is configured to obtain physiologic data from sensors associated with a wearable device of a subject, the sensors being attached to skin of the subject over vascular structures of the subject. The at least one processing device is also configured to determine differences between measured physiologic metrics in the obtained physiologic data and baseline physiologic metrics, and to detect anomalous physiologic events indicative of hypovolemic shock of the subject based at least in part on the determined differences between the measured physiologic metrics and the baseline physiologic metrics. The at least one processing device is further configured to generate notifications responsive to detecting the anomalous physiologic event indicative of hypovolemic shock of the subject, and to deliver the notifications in accordance with notification settings associated with the subject.

Abstract: An apparatus comprises at least one processing device comprising a processor coupled to a memory. The at least one processing device is configured to select physiologic data to be visualized, the selected physiologic data comprising a given set of one or more physiologic parameters collected from a given set of one or more subjects over a given period of time. The at least one processing device is also configured to determine a plot type for visualization of the selected physiologic data, the plot type being determined based at least in part on a repetitiveness of the selected physiologic data over a plurality of time segments in the given period of time. The at least one processing device is further configured to generate a visualization of the selected physiologic data utilizing the determined plot type, and to output the generated visualization of the selected physiologic data via an interactive graphical user interface.

Abstract: A system for controlled neuromodulation procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Systems and methods for imaging, monitoring, stimulating, and/or ablating neurological structures coupled to one or more organs of the lower urinary tract (LUT) are disclosed. Such processes may be used to alter the hormonal secretions from one or more organs, to modulate the growth of an organ, alter the growth rate or rate of perineural invasion of a tumor, or the like. In particular such processes may be used to slow, halt and/or reverse the growth of a prostate gland or a prostate tumor.