Patents by Inventor Lanfen LI

Lanfen LI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT MUTANT (alpha)1-ANTITRYPSIN AND PREPARATION AND USES THEREOF
    Publication number: 20200354433
    Abstract: Provided is a new AAT triple-mutant, and methods to produce and purify the new entity. The new mutant is produced by a structure-based protein design to provide a more thermostable and oxidation-resistant agent for various pharmaceutical applications. The present invention also provides methods for E. coli expression, inclusion body refolding, and purification of the triple-mutant. Furthermore, the invention also provides methods for chemically modifying the purified drug candidate to provide a longer in vivo half-life and achieve better drug efficacy.
    Type: Application
    Filed: July 29, 2020
    Publication date: November 12, 2020
    Inventors: Xinli LIN, Lanfen LI