Patents by Inventor Lap-Chee Tsui
Lap-Chee Tsui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120094842Abstract: Methods of diagnosing risk of pulmonary disease in a mammal with cystic fibrosis are provided comprising screening a biological sample obtained from the mammal for MBL2 or SP-A1 deficiency, and TGFB1 over-expression.Type: ApplicationFiled: November 3, 2008Publication date: April 19, 2012Inventors: Peter Durie, Julian Zielenski, Mary Corey, Andrew Sanford, Peter Pare, Ruslan Dorfman, Yves Berthiaume, Lap-Chee Tsui
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Patent number: 6984487Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.Type: GrantFiled: September 20, 1993Date of Patent: January 10, 2006Assignees: HSC Research Development Corporation, The Board of Regents Acting For and on Behalf of The University of MichiganInventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
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Patent number: 6902907Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.Type: GrantFiled: June 2, 1994Date of Patent: June 7, 2005Assignees: HSC Research Development Corporation, The Board of Regents Acting for and on Behalf of The University of MichiganInventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
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Patent number: 6730777Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.Type: GrantFiled: June 6, 1995Date of Patent: May 4, 2004Assignees: HSC Research Development Corporation, University of MichiganInventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
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Patent number: 6372500Abstract: The invention consists of episomal expression cassettes for expression of a transgene in gene therapy. The expression cassettes consist of regulatory elements of the human cytokeratin gene and a transgene. The invention also includes of liposomes for transfection of epithelial tissue with the cassettes in treatment of cystic fibrosis, emphysema, cancers of epithelial origin arising in the lung or other organs.Type: GrantFiled: November 12, 1999Date of Patent: April 16, 2002Assignee: HSC Research and Development Limited PartnershipInventors: Jim Hu, Yu-Hua Chow, Hugh O'Brodovich, Lap-Chee Tsui
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Patent number: 6063913Abstract: A modified DNA sequence encoding full length cystic fibrosis transmembrane conductance regulator protein is provided to facilitate propagation and/or expression of the protein in living cells and in particular, bacterial cells. The modified DNA sequence comprises at least one of the 13 base pair repeat of exon 6b of the normal gene encoding the conductance regulator protein, as one or more normal nucleotides of the 13 base repeat substituted with an alternate nucleotide which, however, continues to code for the corresponding normal amino acid. Mammalian cells transfected with a vector containing the modified DNA sequence enhances chlorine conductance through the cell wall.Type: GrantFiled: April 12, 1993Date of Patent: May 16, 2000Assignee: HSC Research and Development Limited PartnershipInventors: Lap-Chee Tsui, Johanna M. Rommens
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Patent number: 6020126Abstract: A rapid and sensitive detection method capable of reliably distinguishing fragments identical to a defined sequence from fragments containing a single base pair mismatch relative to the defined sequence. The method employs a peptide analog antisense probe, such as a peptide nucleic acid (PNA) probe, which hybridizes with DNA to forms complexes having higher thermal stability, but greater sensitivity to base pair mismatches, than corresponding DNA/DNA complexes. The method may be used in a number of applications, including genetic screening and hybridization sequencing applications.Type: GrantFiled: March 21, 1997Date of Patent: February 1, 2000Assignees: HSC, Reasearch and Development Limited Partnership, The Board of Trustees of The Leland Stamford Junior UniversityInventors: Christina Carlsson, Maria T. Dulay, Mats Jonsson, Peter Nielson, Bengt Norden, Lap-Chee Tsui, Richard Zare, Julian Zielinski
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Patent number: 6001588Abstract: The identification, isolation and cloning of DNA sequences coding for mutant forms of the cystic fibrosis gene and their gene product are described. DNA sequence information and information relating to the genomic structure of the cystic fibrosis gene are provided. The mutant forms of the CF gene include specific sequence alterations in coding portions or of other genetic information at exon/intron boundaries and altered RNA transcripts and mutant protein products. Such DNA and protein information is useful in developing DNA or protein diagnosis for CF mutations, carrier and patient screening, as well as cloning of mutant genes and manufacturing of their proteins for investigation into therapies for cystic fibrosis.Type: GrantFiled: July 13, 1992Date of Patent: December 14, 1999Assignee: HSC Research Development CorporationInventors: Lap-Chee Tsui, Johanna M. Rommens, Bat-sheva Kerem
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Patent number: 5981178Abstract: The cystic fibrosis gene and its gene product are described for mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.Type: GrantFiled: June 6, 1995Date of Patent: November 9, 1999Assignee: HSC Research Development CorporationInventors: Lap-Chee Tsui, Johanna M. Rommens, Bat-sheva Kerem
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Patent number: 5863770Abstract: A modified DNA sequence encoding full length cystic fibrosis transmembrane conductance regulator protein is provided to facilitate propagation and/or expression of the protein in living cells and in particular, bacterial cells. The modified DNA sequence comprises at least one of the 13 base pair repeat of exon 6b of the normal gene encoding the conductance regulator protein, as one or more normal nucleotides of the 13 base repeat substituted with an alternate nucleotide which, however, continues to code for the corresponding normal amino acid.Type: GrantFiled: February 21, 1996Date of Patent: January 26, 1999Assignee: HSC Research and Development Limited PartnershipInventors: Lap-Chee Tsui, Johanna M. Rommens
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Patent number: 5776677Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.Type: GrantFiled: June 6, 1995Date of Patent: July 7, 1998Assignees: HSC Research Development Corporation, The Board of Regents, Acting for and on Behalf of The University of MichiganInventors: Lap-Chee Tsui, John R. Riordan, Francis S. Collins, Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem, Mitchell L. Drumm, Manuel Buchwald
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Patent number: 5470709Abstract: A method is provided for detecting, ordering and mapping genes or DNA sequences in the genome of eukaryotic cells. The method comprises the steps of releasing free chromatin from the nuclei of the cells and contacting the released free chromatin with at least one detectable probe capable of hybridizing to the genes or DNA sequences to be detected, thereby rendering the genes or DNA sequences detectable.Type: GrantFiled: September 16, 1993Date of Patent: November 28, 1995Assignee: HSC Research & Development Ltd. PartnershipInventors: Henry H. Q. Heng, Lap-Chee Tsui