Abstract: The present disclosure relates to discogenic cell populations, methods of deriving, and methods of using them. The presently described discogenic cell populations may be used to restore or regenerate damaged, diseased, or missing intervertebral discs of a subject. The presently described discogenic cell populations can be derived from and administered or implanted into a subject, or may be derived from an unrelated donor.

Abstract: Disclosed herein are methods and systems for treating an intervertebral disc in a subject in need thereof. In some embodiments, the subject's intervertebral disc has a reduced disc height due to degeneration, damage, and/or disease. In other embodiments, the subject is at risk of losing height in at least one intervertebral disc. In most embodiments, the disclosed methods comprise inserting a needle into the treated disc a first time and a second time. In many embodiments the first and second time may be separated by a period of days or weeks.

Abstract: The present disclosure relates to discogenic cell populations, methods of deriving, and methods of using them. The presently described discogenic cell populations may be used to restore or regenerate damaged, diseased, or missing intervertebral discs of a subject. The presently described discogenic cell populations can be derived from and administered or implanted into a subject, or may be derived from an unrelated donor.