Patents by Inventor Larisa Balaian

Larisa Balaian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING CANCER AND BIOMARKERS TO DETECT CANCER STEM CELL REPROGRAMMING AND PROGRESSION
    Publication number: 20240165145
    Abstract: In alternative embodiment, provided are methods and compositions for treating, ameliorating or preventing diseases and conditions, such as cancer, including cancers associated with stem cells such as, without limitation, myelodysplastic syndrome (MDS) and a myeloproliferative neoplasm like chronic myeloid leukemia (CML) or acute myeloid leukemia (AML), and ablating or killing cancer stem cells. In alternative embodiment, provided are a new set of biomarkers to detect leukemia stem cell reprogramming and CML progression. In alternative embodiment, provided are therapeutic targets for treating myelodysplastic syndrome (MDS) and chronic myeloid leukemia (CML) by targeting edited let-7 transcripts.
    Type: Application
    Filed: September 11, 2023
    Publication date: May 23, 2024
    Inventors: Catriona JAMIESON, Maria Anna ZIPETO, Leslie ROBERTSON, Larisa BALAIAN, Nathaniel Delos SANTOS, Qingfei JIANG
  • METHODS FOR TREATING AND AMELIORATING CANCER
    Publication number: 20240148688
    Abstract: In alternative embodiments, provided are methods for treating and ameliorating a cancer, or recurrence of a cancer such as acute myeloid leukemia (AML) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 (or rebecsinib) and second drug such as an ATP-competitive protein tyrosine kinase inhibitor such as dasatinib. In alternative embodiments, provided are methods for the in vivo inhibition of myeloproliferative neoplasm (MPN) or AML stem cell propagation comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. In alternative embodiments, provided are methods for the in vivo inhibition pre-leukemia stem cell (pre-LSC) transformation into leukemia stem cells (LSCs) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug.
    Type: Application
    Filed: February 1, 2022
    Publication date: May 9, 2024
    Inventors: Catriona JAMIESON, Leslie CREWS ROBERTSON, Michael BURKART, Larisa BALAIAN, Phoebe MONDALA, Cayla MASON, Raymond H. DIEP, James LACLAIR, Thomas WHISENANT, Warren C. CHAN, Inge VAN DER WERF, Peggy WENTWORTH, Wenxue MA
  • Methods for detection and eradication of myeloid leukemia stem cells
    Patent number: 10675267
    Abstract: There are provided, inter alia, methods and compositions for diagnosis and treatment of acute myeloid leukemia (AML), secondary acute myeloid leukemia (sAML), and age-related diseases.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: June 9, 2020
    Assignee: The Regents Of The University Of California
    Inventors: Catriona H.m. Jamieson, Leslie C. Robertson, Larisa Balaian, James J. La Clair, Reymundo Villa, Heather Leu, Nathaniel Delos Santos, Michael D. Burkart
  • COMPOSITIONS AND METHODS FOR TREATING CANCER AND BIOMARKERS TO DETECT CANCER STEM CELL REPROGRAMMING AND PROGRESSION
    Publication number: 20190247413
    Abstract: In alternative embodiment, provided are methods and compositions for treating, ameliorating or preventing diseases and conditions, such as cancer, including cancers associated with stem cells such as, without limitation, myelodysplastic syndrome (MDS) and a myeloproliferative neoplasm like chronic myeloid leukemia (CML) or acute myeloid leukemia (AML), and ablating or killing cancer stem cells. In alternative embodiment, provided are a new set of biomarkers to detect leukemia stem cell reprogramming and CML progression. In alternative embodiment, provided are therapeutic targets for treating myelodysplastic syndrome (MDS) and chronic myeloid leukemia (CML) by targeting edited let-7 transcripts.
    Type: Application
    Filed: June 8, 2017
    Publication date: August 15, 2019
    Inventors: Catriona JAMIESON, Maria Anna ZIPETO, Leslie ROBERTSON, Larisa BALAIAN, Nathaniel Delos SANTOS, Qingfei JIANG
  • METHODS FOR DETECTION AND ERADICATION OF MYELOID LEUKEMIA STEM CELLS
    Publication number: 20180296524
    Abstract: There are provided, inter alia, methods and compositions for diagnosis and treatment of acute myeloid leukemia (AML), secondary acute myeloid leukemia (sAML), and age-related diseases.
    Type: Application
    Filed: September 23, 2016
    Publication date: October 18, 2018
    Inventors: Catriona H.m. Jamieson, Leslie C. Robertson, Larisa Balaian, James J. La Clair, Reymundo Villa, Heather Leu, Nathaniel Delos Santos, Michael D. Burkart