Patents by Inventor Larry A. Couture

Larry A. Couture has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SDC-2 exosome compositions and methods of isolation and use
    Patent number: 11918687
    Abstract: Disclosed herein are compositions comprising isolated exosomes, for instance exosomes wherein at least 20% of the exosomes comprise SDC2, methods of isolation, and methods of use.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: March 5, 2024
    Assignee: ORBSEN THERAPEUTICS LIMITED
    Inventors: Stephen J. Elliman, Jack Kavanaugh, Larry Couture
  • METHODS OF ISOLATION AND USE OF CD39 STROMAL STEM CELLS
    Publication number: 20220228122
    Abstract: Disclosed herein are methods of isolating SDC2+ stromal stem cells and exosomes from SDC2+ stromal stem cells by expression of surface marker CD39. Also disclosed herein are stromal stem cells and exosomes isolated by said methods.
    Type: Application
    Filed: January 28, 2022
    Publication date: July 21, 2022
    Inventors: Stephen J. ELLIMAN, Jack KAVANAUGH, Larry A. COUTURE, Lisa O'FLYNN
  • Methods of isolation and use of CD39 stromal stem cells
    Patent number: 11268067
    Abstract: Disclosed herein are methods of isolating SDC2+ stromal stem cells by expression of surface marker CD39. Also disclosed herein are stromal stem cells isolated by said methods.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: March 8, 2022
    Assignee: ORBSEN THERAPEUTICS LIMITED
    Inventors: Stephen J. Elliman, Jack Kavanaugh, Larry A. Couture, Lisa O'Flynn
  • STROMAL STEM CELL THERAPEUTICS AND METHODS OF USE
    Publication number: 20210154235
    Abstract: Provided herein are stromal stem cell therapeutics and methods of use in treating disease.
    Type: Application
    Filed: May 30, 2018
    Publication date: May 27, 2021
    Inventors: Larry A. COUTURE, Stephen J. ELLIMAN, Lisa O'FLYNN, Jack KAVANAUGH
  • CD39 STROMAL STEM CELLS METHODS OF ISOLATION AND USE
    Publication number: 20200149012
    Abstract: Disclosed herein are methods of isolating SDC2+ stromal stem cells and exosomes from SDC2+ stromal stem cells by expression of surface marker CD39. Also disclosed herein are stromal stem cells and exosomes isolated by said methods.
    Type: Application
    Filed: July 12, 2018
    Publication date: May 14, 2020
    Inventors: Stephen J. ELLIMAN, Jack KAVANAUGH, Larry A. COUTURE, Lisa O'FLYNN
  • SDC-2 EXOSOME COMPOSITIONS AND METHODS OF ISOLATION AND USE
    Publication number: 20190015331
    Abstract: Disclosed herein are compositions comprising isolated exosomes, for instance exosomes wherein at least 20% of the exosomes comprise SDC2, methods of isolation, and methods of use.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 17, 2019
    Inventors: Stephen J. ELLIMAN, Jack Kavanaugh, Larry COUTURE
  • ATTACHMENT SUBSTRATES FOR DIRECTED DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS IN CULTURE
    Publication number: 20130330825
    Abstract: In one embodiment, methods of producing a population of differentiated target cells from a population of undifferentiated pluripotent stem cells (PSC) are provided herein. Such methods may include culturing the population of undifferentiated PSCs, such as human embryonic stem cells (hESC), on an attachment matrix which comprises at least two or more laminin isoforms. The two or more laminin isoforms may include a laminin combination of one or more laminin isoforms that support the hESC cells; and one or more laminin isoforms that would support a population of differentiated target cells. The one or more laminins (LN) that support the hESC cells may be selected from LN-511 or LN-521, while the population of differentiated target cells is a population of cardiomyocytes, and the one or more laminins that would support the cardiomyocytes are selected from LN-411, LN-111, LN-421, LN-211, LN-332, or LN-121.
    Type: Application
    Filed: March 13, 2013
    Publication date: December 12, 2013
    Inventors: Larry A. Couture, Chang-yi Chen
  • Adenovirus vectors for gene therapy
    Patent number: 7318919
    Abstract: Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.
    Type: Grant
    Filed: June 3, 2002
    Date of Patent: January 15, 2008
    Assignee: Genzyme Corporation
    Inventors: Richard Gregory, Donna Armentano, Larry A. Couture, Alan E. Smith
  • Adenovirus vectors for gene therapy
    Publication number: 20030147854
    Abstract: Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.
    Type: Application
    Filed: June 3, 2002
    Publication date: August 7, 2003
    Inventors: Richard J. Gregory, Donna Armentano, Larry A. Couture, Alan E. Smith
  • Adenovirus vectors for gene therapy
    Publication number: 20020164782
    Abstract: Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.
    Type: Application
    Filed: May 11, 2000
    Publication date: November 7, 2002
    Inventors: Richard J. Gregory, Donna Armentano, Larry A. Couture, Alan E. Smith
  • Recovery of chlorine dioxide from gas streams
    Patent number: 6322768
    Abstract: A method for recovering chlorine dioxide from a gas. The method involves contacting gas containing chlorine dioxide with an alkaline metal base and peroxide to form an alkaline metal chlorite solution, and oxidizing the alkaline metal chlorite solution to generate chlorine dioxide.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: November 27, 2001
    Assignee: International Paper Company
    Inventors: Robert L. Graff, Larry A. Couture, Al G. Lewis
  • Gene therapy for cystic fibrosis
    Patent number: 6093567
    Abstract: Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: July 25, 2000
    Assignee: Genzyme Corporation
    Inventors: Richard J. Gregory, Donna Armentano, Larry A. Couture, Alan E. Smith
  • Adenoviral vectors for gene therapy containing deletions in the adenoviral genome
    Patent number: 5882877
    Abstract: Adenoviral vectors which contain deletions of the early regions and/or late genes provide efficient delivery and expression of foreign nucleic acids of interest to patients. These vectors have a particular use in the treatment of cystic fibrosis patients. Furthermore, PAV vectors provide for a second generation of adenoviral vectors that contain the 5' ITR's, the packaging signal and the E1A enhancer. Other adenoviral vectors contain a deletion of the E1 region or a deletion of E4 but retain orf3 or orf6, and can either retain or delete the E3 region.
    Type: Grant
    Filed: July 16, 1997
    Date of Patent: March 16, 1999
    Assignee: Genzyme Corporation
    Inventors: Richard J. Gregory, Donna Armentano, Larry A. Couture, Alan E. Smith
  • CETP Ribozymes
    Patent number: 5705388
    Abstract: A nucleic acid molecule which blocks synthesis and/or expression of mRNAs associated with initial development, progression or regression of vascular disease.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: January 6, 1998
    Assignees: Ribozyme Pharmaceuticals, Inc., Warner-Lambert Company
    Inventors: Larry Couture, Dan Stinchcomb, James McSwiggen, Charles Bisgaier, Michael Pape
  • Adenovirus vector for gene therapy
    Patent number: 5670488
    Abstract: Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.
    Type: Grant
    Filed: October 13, 1993
    Date of Patent: September 23, 1997
    Assignee: Genzyme Corporation
    Inventors: Richard J. Gregory, Donna Armentano, Larry A. Couture, Alan E. Smith