Patents by Inventor Larry Alegria

Larry Alegria has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Medical Device including a Bioactive in a Non-ionic and an Ionic Form and Methods of Preparation Thereof
    Publication number: 20080082038
    Abstract: A medical device having a bioactive in a salt and a free-base form contained within the device and/or coated onto a surface of the device. The salt and the free-base form have different solubilities in an aqueous medium. The elution of bioactive from the device in an aqueous medium is tailored by fixing the ratio of forms. Methods of preparing such a device are also provided.
    Type: Application
    Filed: September 28, 2007
    Publication date: April 3, 2008
    Applicant: Vance Products Incorporated, d/b/a/ Cook Urological Incorporated
    Inventors: Michael Johnson, Larry Alegria, Benjamin Luchsinger
  • Composition and method for covalently coupling an antithrombotic substance and a hydrophilic polymer
    Publication number: 20060159650
    Abstract: An antithrombotic composition includes a hydrophilic polymer backbone and an antithrombotic moiety covalently linked to the hydrophilic polymer backbone. The antithrombotic composition is formed by exposing a hydrophilic polymer including a hydroxyl group to an antithrombotic polysaccharide without having to first aminate the hydrophilic polymer.
    Type: Application
    Filed: January 14, 2005
    Publication date: July 20, 2006
    Applicant: Bacterin, Inc.
    Inventor: Larry Alegria
  • HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
    Publication number: 20050124683
    Abstract: The present invention relates to a series of chemical compounds useful as Human Immunodeficiency Virus (HIV) protease inhibitors and to the use of such compounds as antiviral agents.
    Type: Application
    Filed: September 16, 2004
    Publication date: June 9, 2005
    Inventors: Larry Alegria, Stacie Canan-Koch, Klaus Dress, Buwen Huang, Robert Kumpf, Kathleen Lewis, Jean Matthews, Sylvie Sakata, Scott Virgil
  • N-containing cycloalkyl-substituted amino-thiazole derivatives and pharmaceutical compositions for inhibiting cell proliferation and methods for their use
    Publication number: 20050101595
    Abstract: Aminothiazole compounds with N-containing cycloalkyl at the 2-amino position which are represented by the Formula (I), or a pharmaceutically acceptable prodrug of said compound, pharmaceutically active metabolite or pharmaceutically acceptable salt of said compound, or metabolite thereof, modulate and/or inhibit the cell proliferation and activity of protein kinases. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating malignancies and other disorders by administering effective amounts of such compounds.
    Type: Application
    Filed: February 20, 2004
    Publication date: May 12, 2005
    Inventors: Shao Song Chu, Larry Alegria, Ted Bleckman, Wesley Chong, Rohit Kumar Duvadie, Lin Li, William Romines, Yi Yang