Patents by Inventor Larry D. Holler

Larry D. Holler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of neurodegenerative disease with ovine GM1 gangliosidosis GM1 ganglioside
    Patent number: 11554130
    Abstract: A method of treating a symptom of neurodegenerative disease in a mammal subject includes administering a ganglioside preparation enriched in GM1, derived from an ovine animal afflicted with GM1 gangliosidosis. The ganglioside preparation is prepared through tissue isolation, extraction, and purification processes. The method includes the treatment of a symptom of Huntington's disease and other neurodegenerative diseases. A selective breeding method for producing a GM1 gangliosidosis-affected, scrapie-resistant ovine animal that produces substantially high tissue concentrations of GM1 ganglioside is described. A method to produce multiple successive generations of ovine animals to produce a GM1 gangliosidosis-affected, scrapie-resistant ovine animal and the production of additional generations to improve trait characteristics. The ganglioside product enriched in GM1 is extracted from an ovine animal that is GM1 affected and scrapie-resistant.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: January 17, 2023
    Assignee: Glycoscience Research, Inc.
    Inventors: Larry D. Holler, Susan Holler
  • Treatment of Neurodegenerative Disease with Ovine GM1 Gangliosidosis GM1 Ganglioside
    Publication number: 20200222437
    Abstract: A method of treating a symptom of neurodegenerative disease in a mammal subject includes administering a ganglioside preparation enriched in GM1, derived from an ovine animal afflicted with GM1 gangliosidosis. The ganglioside preparation is prepared through tissue isolation, extraction, and purification processes. The method includes the treatment of a symptom of Huntington's disease and other neurodegenerative diseases. A selective breeding method for producing a GM1 gangliosidosis-affected, scrapie-resistant ovine animal that produces substantially high tissue concentrations of GM1 ganglioside is described. A method to produce multiple successive generations of ovine animals to produce a GM1 gangliosidosis-affected, scrapie-resistant ovine animal and the production of additional generations to improve trait characteristics. The ganglioside product enriched in GM1 is extracted from an ovine animal that is GM1 affected and scrapie-resistant.
    Type: Application
    Filed: January 13, 2020
    Publication date: July 16, 2020
    Inventors: Larry D. Holler, Susan Holler
  • Process for obtaining ganglioside lipids
    Patent number: 5532141
    Abstract: A method is taught whereby improved yields of lipid containing molecules, such as gangliosides, are obtained. Involved is the treatment of neural tissue from animals afflicted with GM1 gangliosidosis. Only members of the ovine family, e.g., sheep are so treated.
    Type: Grant
    Filed: June 13, 1995
    Date of Patent: July 2, 1996
    Inventor: Larry D. Holler