Patents by Inventor Larry D. Sutton

Larry D. Sutton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190100534
    Abstract: Cephem and penem compounds having a styrylmethylene moiety at the 3-position in the cephem or penem ring to which a positively charged leaving group is bonded and wherein the leaving group contains a vicinal diol or is bonded to a unsubstituted or substituted catechol. The leaving group can be a positively charge nitrogen leaving group. Cephems include cephalosporins, cephamycins, carbacephems, and oxacephems. Penems include penems, carbapenems and oxapenems. Preferred cephems are cephalosporins. Preferred penems are carbapenems. Compounds exhibit antibiotic activity against Gram-negative bacteria and/or Gram-positive bacteria. Compounds exhibit antibiotic activity against bacteria which exhibit multi-drug resistance. Compounds of the invention exhibit antibiotic activity against bacterial strains which produce extended spectrum beta-lactamases (ESBL), which produce AmpC beta-lactamases or which produce a carbapenemase.
    Type: Application
    Filed: October 4, 2018
    Publication date: April 4, 2019
    Inventors: Larry D. SUTTON, Robert ZAMBONI, Patrick BUREAU, Avid HASSANPOUR, Laura MAMANI LAPARRA, Marc VIDAL, Simon WOO, Nancy ZHOU, Richard M. KEENAN
  • Publication number: 20180319817
    Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.
    Type: Application
    Filed: May 21, 2018
    Publication date: November 8, 2018
    Inventors: Larry D. SUTTON, Sophia YU
  • Patent number: 10117755
    Abstract: An interbody fusion device includes a base member, a top member, and an expansion mechanism for moving the top member relative to the base member. The expansion mechanism may include a connector drive rod assembly, a gear, a threaded rod, and a support means. The gear ring is coupled to the threaded rod and is rotatable. The expansion mechanism may also include at least one load head coupled to the threaded rod. An alternative interbody fusion device is also disclosed and includes a bottom member, a superior member, and an expansion mechanism for moving the superior member relative to the bottom member. The expansion mechanism includes a first expansion assembly for moving a first end of the superior member relative to the bottom member, a second expansion assembly for moving a second end of the superior member relative to the bottom member, and a connector drive rod assembly.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 6, 2018
    Assignee: BioSpine, LLC
    Inventors: Brian G. Emerick, Ross R. Nichols, Daniel D. Refai, Heidi Stamets, Larry D. Sutton, Brent Walter
  • Patent number: 9975905
    Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making betalactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 22, 2018
    Assignee: Gladius Pharmaceuticals Corporation
    Inventors: Larry D. Sutton, Sophia Yu
  • Publication number: 20160031906
    Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making betalactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 4, 2016
    Inventors: Larry D. SUTTON, Sophia YU
  • Publication number: 20150094814
    Abstract: An interbody fusion device includes a base member, a top member, and an expansion mechanism for moving the top member relative to the base member. The expansion mechanism may include a connector drive rod assembly, a gear, a threaded rod, and a support means. The gear ring is coupled to the threaded rod and is rotatable. The expansion mechanism may also include at least one load head coupled to the threaded rod. An alternative interbody fusion device is also disclosed and includes a bottom member, a superior member, and an expansion mechanism for moving the superior member relative to the bottom member. The expansion mechanism includes a first expansion assembly for moving a first end of the superior member relative to the bottom member, a second expansion assembly for moving a second end of the superior member relative to the bottom member, and a connector drive rod assembly.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 2, 2015
    Inventors: Brian G. Emerick, Ross R. Nichols, Daniel D. Refai, Heidi Stamets, Larry D. Sutton, Brent Walter