Patents by Inventor Larry DeDionisio

Larry DeDionisio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the treatment of corneal dystrophies
    Patent number: 11987809
    Abstract: Methods and compositions for the treatment of a corneal dystrophy in a subject in need thereof are provided. In one aspect, the method includes the step of obtaining a plurality of stem cells comprising a nucleic acid mutation in a corneal dystrophy target nucleic acid from the subject and manipulating the nucleic acid mutation in one or more stem cells of the plurality of stem cells to correct the nucleic acid mutation, thereby forming one or more manipulated stem cells. The manipulated stem cells are isolated and then transplanted into the subject. In some embodiments, the nucleic acid mutation is manipulated using CRISPR system.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: May 21, 2024
    Assignee: Avellino Lab USA, Inc.
    Inventors: Tara Moore, Andrew Nesbit, Gene Lee, Sun-young Cho, Larry DeDionisio
  • Methods for Detecting Alleles Associated with Keratoconus
    Publication number: 20200190587
    Abstract: Systems and methods for detecting single nucleotide polymorphisms (SNPs) associated with keratoconus (KC) in a sample from a subject are described.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 18, 2020
    Applicant: Avellino Lab USA, Inc.
    Inventors: Larry DeDionisio, Tara Moore, Andrew Nesbit
  • Methods for the Treatment of Corneal Dystrophies
    Publication number: 20190085288
    Abstract: Methods and compositions for the treatment of a corneal dystrophy in a subject in need thereof are provided. In one aspect, the method includes the step of obtaining a plurality of stem cells comprising a nucleic acid mutation in a corneal dystrophy target nucleic acid from the subject and manipulating the nucleic acid mutation in one or more stem cells of the plurality of stem cells to correct the nucleic acid mutation, thereby forming one or more manipulated stem cells. The manipulated stem cells are isolated and then transplanted into the subject. In some embodiments, the nucleic acid mutation is manipulated using CRISPR system.
    Type: Application
    Filed: May 11, 2018
    Publication date: March 21, 2019
    Applicant: Avellino Lab USA, Inc.
    Inventors: Tara Moore, Andrew Nesbit, Gene Lee, Sun-young Cho, Larry DeDionisio