Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds.

Abstract: A split crimper for use in a crimping assembly for engaging and heat sealing overlapping layers of a packaging material includes a first crimper portion having a crimping surface and a second crimper portion that is secured to the first crimper portion to form a crimper. Portions of the first and second crimper portions cooperate to define an interior cavity, and a heating element is disposed completely within the interior cavity.

Abstract: A split crimper for use in a crimping assembly for engaging and heat sealing overlapping layers of a packaging material includes a first crimper portion having a crimping surface and a second crimper portion that is secured to the first crimper portion to form a crimper. Portions of the first and second crimper portions cooperate to define an interior cavity, and a heating element is disposed completely within the interior cavity.

Abstract: A split crimper for use in a crimping assembly for engaging and heat sealing overlapping layers of a packaging material includes a first crimper portion having a crimping surface and a second crimper portion that is secured to the first crimper portion to form a crimper. Portions of the first and second crimper portions cooperate to define an interior cavity, and a heating element is disposed completely within the interior cavity.

Abstract: A split crimper for use in a crimping assembly for engaging and heat sealing overlapping layers of a packaging material includes a first crimper portion having a crimping surface and a second crimper portion that is secured to the first crimper portion to form a crimper. Portions of the first and second crimper portions cooperate to define an interior cavity, and a heating element is disposed completely within the interior cavity.

Abstract: A split crimper for use in a crimping assembly for engaging and heat sealing overlapping layers of a packaging material includes a first crimper portion having a crimping surface and a second crimper portion that is secured to the first crimper portion to form a crimper. Portions of the first and second crimper portions cooperate to define an interior cavity, and a heating element is disposed completely within the interior cavity.

Abstract: A split crimper for use in a crimping assembly for engaging and heat sealing overlapping layers of a packaging material includes a first crimper portion having a crimping surface and a second crimper portion that is secured to the first crimper portion to form a crimper. Portions of the first and second crimper portions cooperate to define an interior cavity, and a heating element is disposed completely within the interior cavity.

Abstract: A split crimper for use in a crimping assembly for engaging and heat sealing overlapping layers of a packaging material includes a first crimper portion having a crimping surface and a second crimper portion that is secured to the first crimper portion to form a crimper. Portions of the first and second crimper portions cooperate to define an interior cavity, and a heating element is disposed completely within the interior cavity.

Abstract: A flush cutter of wires located on a patient's teeth has at least one pivotably carried cutting edge. An outer surface of the edge can be positioned adjacent to a surface from which the wire protrudes. An elastic insert or clamp, for griping cut wire ends, is carried adjacent to the edge. The insert has first and second spaced apart ends. A rigid surface is located to pivot toward the edge. The elastic clamp extends, in part, to the inner surface of the edge. As the cutting edge moves toward the rigid surface to cut the wire, the elastic clamp grips the cutoff wire end for removal. The rigid surface can be formed as a second cutting edge that moves toward the one cutting edge.

Abstract: A crimper assembly forms end seals in overlapping portions of the sheet of packaging material after being folded about an article. The crimper assembly includes a crimper including a base, an insert that is formed from a resilient material, and a support plate that is formed from a rigid material. The insert has a surface that is adapted to engage and seal overlapping layers of a packaging material. The insert is disposed between the base and the support plate. The support plate is secured to the body to retain and support the insert thereon. The insert and the support plate may be formed as separate pieces or may be secured together as a single piece. To prevent excessive compression of the insert, the insert can have an aperture formed therethrough, and the support plate can have a protrusion formed thereon that extends through the aperture into abutment with the base.

Abstract: A crimper assembly forms end seals in overlapping portions of the sheet of packaging material after being folded about an article. The crimper assembly includes a crimper including a base, an insert that is formed from a resilient material, and a support plate that is formed from a rigid material. The insert has a surface that is adapted to engage and seal overlapping layers of a packaging material. The insert is disposed between the base and the support plate. The support plate is secured to the body to retain and support the insert thereon. The insert and the support plate may be formed as separate pieces or may be secured together as a single piece. To prevent excessive compression of the insert, the insert can have an aperture formed therethrough, and the support plate can have a protrusion formed thereon that extends through the aperture into abutment with the base.

Abstract: A flush cutter of wires located on a patient's teeth has at least one pivotably carried cutting edge. An outer surface of the edge can be positioned adjacent to a surface from which the wire protrudes. An elastic insert or clamp, for griping cut wire ends, is carried adjacent to the edge. The insert has first and second spaced apart ends. A rigid surface is located to pivot toward the edge. The elastic clamp extends, in part, to the inner surface of the edge. As the cutting edge moves toward the rigid surface to cut the wire, the elastic clamp grips the cutoff wire end for removal. The rigid surface can be formed as a second cutting edge that moves toward the one cutting edge.

Abstract: A crimper assembly includes upper and lower crimper bars which are rotated relative to a sheet of packaging material. A pair of upper crimpers are secured to opposite sides of the upper crimper bar, while a pair of lower crimpers are secured to opposite sides of the lower crimper bars. Each of the upper crimpers includes a metallic base having an outwardly facing portion with an undulating cross sectional shape. A slot is formed in the outwardly facing portion of the upper crimper, and a cutting blade is retained therein. In a first embodiment, an insert is secured to the base of each of the upper crimpers. The insert includes a rigid shank having a lip portion extending therefrom. Portions of the outer surface of the shank are covered by a layer of a relatively resilient material. The layer is formed from a material which is suitable for compressing overlapping portions of the folded sheet of packaging material to form an intermeshing seal pattern.

Abstract: A rodent trap for drowning a plurality of rodents and other small pests without the need for resetting the trap is disclosed. The inventive device includes a ramp engageable to a rim of a conventional pail and a rotating body positionable horizontally within the pail. The pail is partially filled with water or a mixture of water and ethylene glycol in such manner that the rotating body is free to rotate a distance above the water or mixture line. The rotating body includes a cylindrical body rotatably mounted to a shaft in such manner that a rodent or like pest is unable to feed upon a rodent-attracting substance such as peanut butter spread on the cylindrical body without stepping upon the cylindrical body and thereby causing the cylindrical body to rotate and force the rodent or like pest into the water or mixture of water and ethylene glycol.

Abstract: A crimper assembly includes upper and lower crimper bars which are rotated relative to a sheet of packaging material. A pair of upper crimpers are secured to opposite sides of the upper crimper bar, while a pair of lower crimpers are secured to opposite sides of the lower crimper bars. Each of the upper crimpers includes a metallic base having an outwardly facing portion with an undulating cross sectional shape. A slot is formed in the outwardly facing portion of the upper crimper, and a cutting blade is retained therein. In a first embodiment, an insert is secured to the base of each of the upper crimpers. The insert includes a rigid shank having a lip portion extending therefrom. Portions of the outer surface of the shank are covered by a layer of a relatively resilient material. The layer is formed from a material which is suitable for compressing overlapping portions of the folded sheet of packaging material to form an intermeshing seal patter.

Abstract: The flooring structure of this invention controls electrostatic charges. The normal presence of moisture will not affect the floor structure's ability to control electrostatic charges. A moisture detector circuit will, however, indicate the presence of moisture, and can activate means for drying this moisture. The resistance of the flooring structure can be adjusted so that electrostatic charges are dissipated at different rates. Multiple floor structures with different resistance values can be placed side by side. Improper grounding of the flooring structure can be detected and corrected, and the resistance of the flooring structure system can be determined.

Abstract: The flooring structure of this invention controls electrostatic charges. The normal presence of moisture will not affect the floor structure's ability to control electrostatic charges. A moisture detector circuit will, however, indicate the presence of moisture, and can activate means for drying this moisture. The resistance of the flooring structure can be adjusted so that electrostatic charges are dissipated at different rates. Multiple floor structures with different resistance values can be placed side by side. Improper grounding of the flooring structure can be detected and corrected, and the resistance of the flooring structure system can be determined.

Abstract: In continuous packaging of comestibles in individual packages of thermo plastic sheet material, elongate, reciprocating crimper bars or dies simultaneously sever the packages and inpart end crimp seals to the packages but unfortunately featuring a high rate of rejects overcome by a special contour in the surface of one of the said crimper dies, according to present discovery.