Patents by Inventor Larry Green

Larry Green has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS
    Publication number: 20240140915
    Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.
    Type: Application
    Filed: September 20, 2023
    Publication date: May 2, 2024
    Inventors: Shota Kikuchi, Betty Lam, Jason Green, Don Rogness, David Weinstein, Larry Burgess, Benjamin Horning, Kelsey Lamb, Zachary Owyang, Robert Malmstrom
  • PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS
    Publication number: 20240067612
    Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.
    Type: Application
    Filed: July 5, 2023
    Publication date: February 29, 2024
    Inventors: Shota Kikuchi, Betty Lam, Jason Green, Don Rogness, David Weinstein, Larry Burgess, Benjamin Horning, Kelsey Lamb, Zach Owyang, Robert Malmstrom
  • ANTIBODIES DIRECTED TO HER-3 AND USES THEREOF
    Publication number: 20230059353
    Abstract: The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Expression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.
    Type: Application
    Filed: March 4, 2022
    Publication date: February 23, 2023
    Applicants: DAIICHI SANKYO EUROPE GMBH, AMGEN INC.
    Inventors: MIKE ROTHE, MARTIN TREDER, ERIC BORGES, LARRY GREEN, SUSANNE HARTMANN
  • ANTI-CD47 ANTIBODIES
    Publication number: 20220267440
    Abstract: The present invention provides anti-CD47 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic and diagnostic methods for the treatment of cancer, ischemic-reperfusion injury, and other diseases.
    Type: Application
    Filed: May 6, 2022
    Publication date: August 25, 2022
    Inventors: John Lippincott, Dana Duey, Larry Green
  • Genetic engineering of non-human animals for the production of chimeric antibodies
    Patent number: 11352444
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: June 7, 2022
    Assignee: ABLEXIS, LLC
    Inventors: Larry Green, Hiroaki Shizuya
  • Anti-CD47 antibodies
    Patent number: 11352425
    Abstract: The present invention provides anti-CD47 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic and diagnostic methods for the treatment of cancer, ischemic-reperfusion injury, and other diseases.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: June 7, 2022
    Assignee: ABSOS, LLC
    Inventors: John Lippincott, Dana Duey, Larry Green
  • Genetic engineering of non-human animals for the production of chimeric antibodies
    Patent number: 11242409
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: February 8, 2022
    Assignee: ABLEXIS, LLC
    Inventors: Larry Green, Hiroaki Shizuya
  • Genetic engineering of non-human animals for the production of chimeric antibodies
    Patent number: 11220555
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: January 11, 2022
    Assignee: ABLEXIS, LLC
    Inventors: Larry Green, Hiroaki Shizuya
  • Genetic engineering of non-human animals for the production of chimeric antibodies
    Patent number: 11104743
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: August 31, 2021
    Assignee: ABLEXIS, LLC
    Inventors: Larry Green, Hiroaki Shizuya
  • Genetic engineering of non-human animals for the production of chimeric antibodies
    Patent number: 11104744
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: August 31, 2021
    Assignee: ABLEXIS, LLC
    Inventors: Larry Green, Hiroaki Shizuya
  • GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
    Publication number: 20210002385
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Application
    Filed: September 15, 2020
    Publication date: January 7, 2021
    Inventors: Larry Green, Hiroaki Shizuya
  • GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
    Publication number: 20200407464
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Application
    Filed: September 15, 2020
    Publication date: December 31, 2020
    Inventors: Larry Green, Hiroaki Shizuya
  • GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
    Publication number: 20200407466
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Application
    Filed: September 15, 2020
    Publication date: December 31, 2020
    Inventors: Larry Green, Hiroaki Shizuya
  • GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
    Publication number: 20200407465
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Application
    Filed: September 15, 2020
    Publication date: December 31, 2020
    Inventors: Larry Green, Hiroaki Shizuya
  • GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
    Publication number: 20200377619
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Application
    Filed: August 19, 2020
    Publication date: December 3, 2020
    Inventors: Larry Green, Hiroaki Shizuya
  • Genetic engineering of non-human animals for the production of chimeric antibodies
    Patent number: 10836832
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: November 17, 2020
    Assignee: ABLEXIS, LLC
    Inventors: Larry Green, Hiroaki Shizuya
  • Genetic engineering of non-human animals for the production of chimeric antibodies
    Patent number: 10829564
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: November 10, 2020
    Assignee: ABLEXIS, LLC
    Inventors: Larry Green, Hiroaki Shizuya
  • Key fob for a key management system
    Patent number: 10748363
    Abstract: A key fob for retaining a key or other object, including: a body structure manufactured from a printed circuit board material; a key ring structure manufactured from the printed circuit board material coupled to the body structure; and a conductive loop disposed one or more of within, on a surface of, and coupled to the printed circuit board material of the key ring structure. Optionally, the body structure and the key ring structure are integrally formed from the printed circuit board material.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: August 18, 2020
    Assignee: Marcon International Inc
    Inventors: Bobby Jain, Ric Stone, Larry Green
  • GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
    Publication number: 20200181286
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Application
    Filed: February 13, 2020
    Publication date: June 11, 2020
    Inventors: Larry Green, Hiroaki Shizuya
  • GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
    Publication number: 20200181285
    Abstract: The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
    Type: Application
    Filed: February 13, 2020
    Publication date: June 11, 2020
    Inventors: Larry Green, Hiroaki Shizuya