Patents by Inventor Larry Greenfield

Larry Greenfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant diphtheria toxin conjugates
    Patent number: 5792458
    Abstract: A potent and specific immunotoxin is prepared by coupling an inactivated diphtheria toxin to a binding moiety such as a monoclonal antibody or transferrin. The immunotoxins are specific for human tumors and leukemias and are indistinguishable in cell toxicity from that of the native toxin linked to the binding domain without the toxicity to other cells. The immunotoxin is useful in treating graft versus host disease as well as selectively killing tumor cells, such as medulloblastoma and glioblastoma cells.
    Type: Grant
    Filed: October 17, 1994
    Date of Patent: August 11, 1998
    Assignees: The United States of America as represented by the Department of Health and Human Services, Cetus Corporation
    Inventors: Virginia G. Johnson, Larry Greenfield, Richard J. Youle, Walter Laird
  • Method of preparing diphtheria immunotoxins
    Patent number: 5208021
    Abstract: A potent and specific immunotoxin is prepared by coupling an inactivated diphteria toxin to a binding moiety such as a monoclonal antibody or transferrin. The immunotoxins are specific for human tumors and leukemias and are indistinguishable in cell toxicity from that of the native toxin linked to the binding domain without the toxicity to other cells. The immunotoxin is useful in treating graft versus host disease as well as selectively killing tumor cells, such as medulloblastoma and glioblastoma cells.
    Type: Grant
    Filed: January 25, 1989
    Date of Patent: May 4, 1993
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Cetus Corporation
    Inventors: Virginia G. Johnson, Larry Greenfield, Richard J. Youle, Walter Laird