Patents by Inventor Larry I. Benowitz
Larry I. Benowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11712444Abstract: The present invention features methods and composition directed to treating neuronal injury, CNS lesion, and/or promoting axon regeneration using a phosphine sulfide-stabilized phosphine.Type: GrantFiled: September 9, 2020Date of Patent: August 1, 2023Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, GEORGIA TECH RESEARCH CORPORATIONInventors: Elena G. Sergeeva, Paul A. Rosenberg, Larry I. Benowitz, Christoph J. Fahrni, Michael Thomas Morgan
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Publication number: 20210069216Abstract: The present invention features methods and composition directed to treating neuronal injury, CNS lesion, and/or promoting axon regeneration using a phosphine sulfide-stabilized phosphine.Type: ApplicationFiled: September 9, 2020Publication date: March 11, 2021Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, GEORGIA TECH RESEARCH CORPORATIONInventors: ELENA G. SERGEEVA, PAUL A. ROSENBERG, LARRY I. BENOWITZ, CHRISTOPH J. FAHRNI, THOMAS MORGAN
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Publication number: 20180085359Abstract: Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron. Also disclosed are methods of treating a subject for a CNS lesion, comprising, administering to the subject a therapeutically effective amount of a chelating agent, Also disclosed are devices for promoting regeneration in a lesioned neuron, and pharmaceutical compositions comprising a therapeutically effective amount of a chelating agent formulated for localized administration directly to an injured neuron. Examples of such chelating agents are provided.Type: ApplicationFiled: September 20, 2017Publication date: March 29, 2018Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Larry I. Benowitz, Stephen J. Lippard, Paul Rosenberg, Yiqing Li, Zhen Huang
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Patent number: 8912144Abstract: Disclosed herein is a method for stimulating axonal outgrowth of central nervous system (CNS) neurons comprising contacting the CNS neurons with an effective amount of NEP1-40 and inosine, to thereby stimulate axonal outgrowth. The method may further comprise contacting the CNS neurons with a cAMP modulator that increases the concentration of intracellular cAMP. Also disclosed is a method for treating a neurological disorder selected from the group consisting of traumatic brain injury, stroke, spinal cord injury, optic neuropathy, retinal nerve damage and optic nerve damage, in a patient in need thereof comprising administering an effective amount of NEP1-40 and inosine to the patient.Type: GrantFiled: May 28, 2010Date of Patent: December 16, 2014Assignee: Children's Medical Center CorporationInventor: Larry I. Benowitz
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Publication number: 20140179741Abstract: Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron. Also disclosed are methods of treating a subject for a CNS lesion, comprising, administering to the subject a therapeutically effective amount of a chelating agent, Also disclosed are devices for promoting regeneration in a lesioned neuron, and pharmaceutical compositions comprising a therapeutically effective amount of a chelating agent formulated for localized administration directly to an injured neuron. Examples of such chelating agents are provided.Type: ApplicationFiled: October 10, 2013Publication date: June 26, 2014Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Larry I. Benowitz, Stephen J. Lippard, Paul Rosenberg, Yiqing Li, Zhen Huang
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Publication number: 20110071088Abstract: The present invention is based on the discovery that suppressing the activity of the Nogo receptor (NgR) alone does not result in extensive axon regeneration unless the intrinsic growth program of neurons is also activated. Accordingly, the present invention is directed to methods of stimulating axon regeneration using a combination therapy wherein agents that inhibit NgR activity or downstream pathways activated by inhibitory signals are combined with agents that activate the growth pathway of neurons (e.g. polypeptide growth factors, activators of macrophages, purine nucleosides, or hexoses).Type: ApplicationFiled: May 28, 2010Publication date: March 24, 2011Applicant: CHILDRENS MEDICAL CENTER CORPORATIONInventor: Larry I. Benowitz
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Patent number: 7666843Abstract: The present invention provides methods and compositions for producing a neurosalutary effect in a subject useful in treatment of neurological disorders, including retinal and optic nerve damage, in a subject in need thereof. The method includes administering to a subject a therapeutically effective amount of a hexose, such as mannose.Type: GrantFiled: September 25, 2003Date of Patent: February 23, 2010Assignee: Children's Medical Center CorporationInventors: Larry I. Benowitz, Carleen Ann Irwin
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Patent number: 7625864Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.Type: GrantFiled: June 30, 2008Date of Patent: December 1, 2009Assignee: Children's Medical Center CorporationInventors: Larry I. Benowitz, Yuqin Yin
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Publication number: 20090156496Abstract: Disclosed herein is a method for treating and/or preventing peripheral nerve damage in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.Type: ApplicationFiled: May 14, 2007Publication date: June 18, 2009Applicant: CHILDREN'S MEDICAL CENTER CORPORATION, INC.Inventors: Larry I. Benowitz, Yuqin Yin
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Publication number: 20090029920Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.Type: ApplicationFiled: June 30, 2008Publication date: January 29, 2009Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Larry I. Benowitz, Yuqin Yin
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Publication number: 20080274077Abstract: The present invention is based on the discovery that suppressing the activity of the Nogo receptor (NgR) alone does not result in extensive axon regeneration unless the intrinsic growth program of neurons is also activated Accordingly, the present invention is directed to methods of stimulating axon regeneration using a combination therapy wherein agents that inhibit NgR activity or downstream pathways activated by inhibitory signals are combined with agents that activate the growth pathway of neurons (e.g. polypeptide growth factors, activators of macrophages, purine nucleosides, or hexoses).Type: ApplicationFiled: December 16, 2004Publication date: November 6, 2008Applicant: Children's Medical Center CorporationInventors: Larry I. Benowitz, Dietmar Fischer
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Patent number: 7407937Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.Type: GrantFiled: May 17, 2007Date of Patent: August 5, 2008Assignee: Children's Medical Center CorporationInventors: Larry I. Benowitz, Yuqin Yin
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Patent number: 7338666Abstract: Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.Type: GrantFiled: May 19, 2005Date of Patent: March 4, 2008Inventor: Larry I. Benowitz
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Patent number: 7238529Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.Type: GrantFiled: September 3, 2004Date of Patent: July 3, 2007Assignee: Children's Medical Center CorporationInventors: Larry I. Benowitz, Yuqin Yin
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Patent number: 7172871Abstract: Methods and compositions for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons in conditions such as epilepsy, e.g., posttraumatic epilepsy, and neuropathic pain syndrome, are also provided. These methods generally involve contacting the central nervous system neurons with a compound that modulates the activity of N-kinase, or analog thereof. The methods and compositions are particularly useful for modulating the axonal outgrowth of mammalian central nervous system neurons, such as mammalian cortical neurons or retinal ganglion cells. Pharmaceutical and packaged formulations that include the compounds of the invention that modulate the activity of N-kinase are also provided.Type: GrantFiled: September 7, 2000Date of Patent: February 6, 2007Assignee: Children's Medical Center CorporationInventor: Larry I. Benowitz
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Patent number: 6855690Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.Type: GrantFiled: November 14, 2002Date of Patent: February 15, 2005Assignee: Children's Medical Center CorporationInventor: Larry I. Benowitz
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Publication number: 20040014710Abstract: Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.Type: ApplicationFiled: March 10, 2003Publication date: January 22, 2004Inventor: Larry I. Benowitz
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Publication number: 20030153501Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.Type: ApplicationFiled: November 14, 2002Publication date: August 14, 2003Inventor: Larry I. Benowitz
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Patent number: 6551612Abstract: Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.Type: GrantFiled: November 29, 2001Date of Patent: April 22, 2003Assignee: Children's Medical Center CorporationInventor: Larry I. Benowitz
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Publication number: 20020160933Abstract: Methods and compositions for producing a neurosalutary effect in a subject are provided. These methods generally involve administering to a subject a therapeutically effective amount of a compound that modulates the activity of N-kinase, or analog thereof. Pharmaceutical and packaged formulations including the compounds of the invention, e.g., compounds that modulate the activity of N-kinase, are also provided.Type: ApplicationFiled: September 7, 2001Publication date: October 31, 2002Applicant: Children's Medical Center CorporationInventor: Larry I. Benowitz