Patents by Inventor Larry I. Benowitz

Larry I. Benowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180085359
    Abstract: Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron. Also disclosed are methods of treating a subject for a CNS lesion, comprising, administering to the subject a therapeutically effective amount of a chelating agent, Also disclosed are devices for promoting regeneration in a lesioned neuron, and pharmaceutical compositions comprising a therapeutically effective amount of a chelating agent formulated for localized administration directly to an injured neuron. Examples of such chelating agents are provided.
    Type: Application
    Filed: September 20, 2017
    Publication date: March 29, 2018
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Larry I. Benowitz, Stephen J. Lippard, Paul Rosenberg, Yiqing Li, Zhen Huang
  • Patent number: 8912144
    Abstract: Disclosed herein is a method for stimulating axonal outgrowth of central nervous system (CNS) neurons comprising contacting the CNS neurons with an effective amount of NEP1-40 and inosine, to thereby stimulate axonal outgrowth. The method may further comprise contacting the CNS neurons with a cAMP modulator that increases the concentration of intracellular cAMP. Also disclosed is a method for treating a neurological disorder selected from the group consisting of traumatic brain injury, stroke, spinal cord injury, optic neuropathy, retinal nerve damage and optic nerve damage, in a patient in need thereof comprising administering an effective amount of NEP1-40 and inosine to the patient.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: December 16, 2014
    Assignee: Children's Medical Center Corporation
    Inventor: Larry I. Benowitz
  • Publication number: 20140179741
    Abstract: Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron. Also disclosed are methods of treating a subject for a CNS lesion, comprising, administering to the subject a therapeutically effective amount of a chelating agent, Also disclosed are devices for promoting regeneration in a lesioned neuron, and pharmaceutical compositions comprising a therapeutically effective amount of a chelating agent formulated for localized administration directly to an injured neuron. Examples of such chelating agents are provided.
    Type: Application
    Filed: October 10, 2013
    Publication date: June 26, 2014
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Larry I. Benowitz, Stephen J. Lippard, Paul Rosenberg, Yiqing Li, Zhen Huang
  • Publication number: 20110071088
    Abstract: The present invention is based on the discovery that suppressing the activity of the Nogo receptor (NgR) alone does not result in extensive axon regeneration unless the intrinsic growth program of neurons is also activated. Accordingly, the present invention is directed to methods of stimulating axon regeneration using a combination therapy wherein agents that inhibit NgR activity or downstream pathways activated by inhibitory signals are combined with agents that activate the growth pathway of neurons (e.g. polypeptide growth factors, activators of macrophages, purine nucleosides, or hexoses).
    Type: Application
    Filed: May 28, 2010
    Publication date: March 24, 2011
    Applicant: CHILDRENS MEDICAL CENTER CORPORATION
    Inventor: Larry I. Benowitz
  • Patent number: 7666843
    Abstract: The present invention provides methods and compositions for producing a neurosalutary effect in a subject useful in treatment of neurological disorders, including retinal and optic nerve damage, in a subject in need thereof. The method includes administering to a subject a therapeutically effective amount of a hexose, such as mannose.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: February 23, 2010
    Assignee: Children's Medical Center Corporation
    Inventors: Larry I. Benowitz, Carleen Ann Irwin
  • Patent number: 7625864
    Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: December 1, 2009
    Assignee: Children's Medical Center Corporation
    Inventors: Larry I. Benowitz, Yuqin Yin
  • Publication number: 20090156496
    Abstract: Disclosed herein is a method for treating and/or preventing peripheral nerve damage in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
    Type: Application
    Filed: May 14, 2007
    Publication date: June 18, 2009
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION, INC.
    Inventors: Larry I. Benowitz, Yuqin Yin
  • Publication number: 20090029920
    Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
    Type: Application
    Filed: June 30, 2008
    Publication date: January 29, 2009
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Larry I. Benowitz, Yuqin Yin
  • Publication number: 20080274077
    Abstract: The present invention is based on the discovery that suppressing the activity of the Nogo receptor (NgR) alone does not result in extensive axon regeneration unless the intrinsic growth program of neurons is also activated Accordingly, the present invention is directed to methods of stimulating axon regeneration using a combination therapy wherein agents that inhibit NgR activity or downstream pathways activated by inhibitory signals are combined with agents that activate the growth pathway of neurons (e.g. polypeptide growth factors, activators of macrophages, purine nucleosides, or hexoses).
    Type: Application
    Filed: December 16, 2004
    Publication date: November 6, 2008
    Applicant: Children's Medical Center Corporation
    Inventors: Larry I. Benowitz, Dietmar Fischer
  • Patent number: 7407937
    Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: August 5, 2008
    Assignee: Children's Medical Center Corporation
    Inventors: Larry I. Benowitz, Yuqin Yin
  • Patent number: 7338666
    Abstract: Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: March 4, 2008
    Inventor: Larry I. Benowitz
  • Patent number: 7238529
    Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: July 3, 2007
    Assignee: Children's Medical Center Corporation
    Inventors: Larry I. Benowitz, Yuqin Yin
  • Patent number: 7172871
    Abstract: Methods and compositions for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons in conditions such as epilepsy, e.g., posttraumatic epilepsy, and neuropathic pain syndrome, are also provided. These methods generally involve contacting the central nervous system neurons with a compound that modulates the activity of N-kinase, or analog thereof. The methods and compositions are particularly useful for modulating the axonal outgrowth of mammalian central nervous system neurons, such as mammalian cortical neurons or retinal ganglion cells. Pharmaceutical and packaged formulations that include the compounds of the invention that modulate the activity of N-kinase are also provided.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: February 6, 2007
    Assignee: Children's Medical Center Corporation
    Inventor: Larry I. Benowitz
  • Patent number: 6855690
    Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: February 15, 2005
    Assignee: Children's Medical Center Corporation
    Inventor: Larry I. Benowitz
  • Publication number: 20040014710
    Abstract: Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.
    Type: Application
    Filed: March 10, 2003
    Publication date: January 22, 2004
    Inventor: Larry I. Benowitz
  • Publication number: 20030153501
    Abstract: The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
    Type: Application
    Filed: November 14, 2002
    Publication date: August 14, 2003
    Inventor: Larry I. Benowitz
  • Patent number: 6551612
    Abstract: Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: April 22, 2003
    Assignee: Children's Medical Center Corporation
    Inventor: Larry I. Benowitz
  • Publication number: 20020160933
    Abstract: Methods and compositions for producing a neurosalutary effect in a subject are provided. These methods generally involve administering to a subject a therapeutically effective amount of a compound that modulates the activity of N-kinase, or analog thereof. Pharmaceutical and packaged formulations including the compounds of the invention, e.g., compounds that modulate the activity of N-kinase, are also provided.
    Type: Application
    Filed: September 7, 2001
    Publication date: October 31, 2002
    Applicant: Children's Medical Center Corporation
    Inventor: Larry I. Benowitz
  • Publication number: 20020137721
    Abstract: Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.
    Type: Application
    Filed: May 14, 2002
    Publication date: September 26, 2002
    Inventor: Larry I. Benowitz
  • Publication number: 20020128223
    Abstract: Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.
    Type: Application
    Filed: May 14, 2002
    Publication date: September 12, 2002
    Inventor: Larry I. Benowitz