Patents by Inventor Larry J. Braga

Larry J. Braga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing a sterile, dry crosslinking agent
    Patent number: 5643464
    Abstract: The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention are also disclosed.
    Type: Grant
    Filed: June 30, 1995
    Date of Patent: July 1, 1997
    Assignee: Collagen Corporation
    Inventors: Woonza M. Rhee, Richard A. Berg, Joel S. Rosenblatt, Jacqueline A. Schroeder, Larry J. Braga, Thomas L. Smestad, Abigail Freeman
  • Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
    Patent number: 5550187
    Abstract: The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention are also disclosed.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: August 27, 1996
    Assignee: Collagen Corporation
    Inventors: Woonza M. Rhee, Richard A. Berg, Joel S. Rosenblatt, Jacqueline A. Tefft, Larry J. Braga, Thomas L. Smestad
  • Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
    Patent number: 5527856
    Abstract: The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention am also disclosed.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: June 18, 1996
    Assignee: Collagen Corporation
    Inventors: Woonza M. Rhee, Richard A. Berg, Joel S. Rosenblatt, Jacqueline A. Tefft, Larry J. Braga, Thomas L. Smestad