Abstract: Compositions and methods for down modulating target gene expression with RNA interference, as well as methods for administering said compositions are disclosed. The method comprises administering a first strand to a cell, incubating the cell for a time period suitable for uptake of the first oligo prior to administering a second strand, wherein the first strand and said second strand form an intracellular duplex which is effective to catalyze degradation of gene target mRNA or inhibit translation of said mRNA.

Abstract: The present invention provides a variety of nucleic acid based therapeutics and methods of use thereof which are effective to beneficially reprogram diseased cells such that they exhibit more desirable phenotypes. Also provided are compositions and methods to reprogram normal cells for medical and commercial purposes.

Abstract: A method aligns a second image of an object taken at a second time with a first image taken at a first time, wherein the object experiences motion relative to an imager between the first and second times. The images are formed of sets of pixels arranged horizontally and vertically in a pattern. The method operates on the pixels of the second image by performing a series of operations to affect an affine transformation without performing matrix arithmetic, preferably by table look-up. The method shifts the pixels of the second image vertically by a constant vertical offset, shifts the pixels of the second image horizontally by a constant horizontal offset, shears the second image horizontally by a skew factor, shears the second image vertically by a skew factor, scales the second image horizontally by a horizontal scale factor; and scale the second image vertically by a vertical scale factor.

Abstract: Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens associated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders. Also provided are methods for modulating the efficacy of nucleic acid based therapeutics.

Abstract: Compositions and methods useful for the treatment of aberrant programming diseases, particularly those associated with aberrant apoptosis are disclosed

Abstract: Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens associated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders. Also provided are methods for modulating the efficacy of nucleic acid based therapeutics.

Abstract: Compositions and methods useful for the treatment of aberrant programming diseases, particularly those associated with aberrant apoptosis are disclosed

Abstract: The present invention provides methods and compositions useful in treating certain diseases herein termed “Aberrant Programming Diseases,” including cancer and AIDS. According to one aspect of the invention, there is provided a method for treating an individual having an Aberrant Programming disease comprising administering to said individual an effective amount of a composition selected from the group consisting of an expression vector, a double stranded oligodeoxynucleotide, and an antisense oligodeoxynucleotide; said composition capable of regulating expression of a transcriptional regulator, said transcriptional regulator being expressed by the Aberrant Programming cells and further characterized by exhibiting a therapeutically useful change in said cell behavior in the Reprogramming Test. In a separate embodiment new antisense oligodeoxynucleotides are provided.

Abstract: A method aligns a second image of an object taken at a second time with a first image taken at a first time, wherein the object experiences motion relative to an imager between the first and second times. The images are formed of sets of pixels arranged horizontally and vertically in a pattern. The method operates on the pixels of the second image by performing a series of operations to affect an affine transformation without performing matrix arithmetic, preferably by table look-up. The method shifts the pixels of the second image vertically by a constant vertical offset, shifts the pixels of the second image horizontally by a constant horizontal offset, shears the second image horizontally by a skew factor, shears the second image vertically by a skew factor, scales the second image horizontally by a horizontal scale factor; and scale the second image vertically by a vertical scale factor.

Abstract: Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens associated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders. Also provided are methods for modulating the efficacy of nucleic acid based therapeutics.

Abstract: Methods and systems form a decodable composite image of an optical code that experiences motion. A method according to one embodiment forms a first image of at least a first portion of the optical code at a first time and a second image of at least a second portion of the optical code at a second time, whereby the optical code may undergo relative motion between the first and second times. The method determines one or more of the following parameters of an affine transformation relating the second image to the first image: vertical offset, horizontal offset, horizontal skew factor, vertical skew factor, horizontal scale factor, and vertical scale factor. The method aligns one of the first and second images to the other by utilizing the determined parameters to implement the affine transformation, thereby forming an aligned image. Finally, the method combines elements of the aligned imaged and the other image to form the decodable composite image of the optical code.

Abstract: Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens assocated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders.

Abstract: Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens assocated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders.

Abstract: Methods and apparatus for mixing two or more drilling fluid components to form a drilling fluid composition. In one embodiment, a method is provided which comprises (a) combining the components in a substantially sealed mixing tank to form a mixture, at least one of the drilling fluid components being dispensed under substantially sealed and externally dust-free conditions from at least one bulk bag into the tank, (b) agitating the mixture within the mixing tank, and (c) circulating at least a portion of the mixture from the mixing tank through grinding means for breaking apart agglomerates within the mixture.

Abstract: Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens associated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders.

Abstract: The present invention provides novel compositions and methods useful in cancer therapy for inhibiting the multidrug resistance phenotype, which often thwarts long-term chemotherapeutic regimens. The novel compositions of matter comprise oligonucleotides targeted to the human MDR1 and MRP genes, which inhibit expression of these genes, thereby rendering tumors and other forms of cancer more susceptible to the cytotoxic effects of chemotherapeutic agents. Oligonucleotides are also provided that inhibit the multidrug resistance phenotype by exerting an aptameric effect.

Abstract: The present invention provides novel compositions and methods useful in cancer therapy for inhibiting the multidrug resistance phenotype, which often thwarts long-term chemotherapeutic regimens. The novel compositions of matter comprise oligonucleotides targeted to the human MDR1 and MRP genes, which inhibit expression of these genes, thereby rendering tumors and other forms of cancer more susceptible to the cytotoxic effects of chemotherapeutic agents. Oligonucleotides are also provided that inhibit the multidrug resistance phenotype by exerting an aptameric effect.

Abstract: The present invention provides methods useful in autologous bone marrow transplantation and cancer therapy. According to one aspect of the invention, bone marrow cells from a patient having cancer are treated with selected antisense oligonucleotides in order to deplete the bone marrow of malignant cells prior to infusion back into the bone marrow donor. In a separate embodiment, selected antisense oligonucleotides are administered systemically for anticancer therapy.

Abstract: Disclosed is an apparatus and method for cutting or marking fish fillets and other foodstuffs of varying cross-section into portions of predetermined size by conveying each product through a volume scanning unit, computing correct cut locations, and then cutting or marking at each location using a guillotine-type knife mechanism. The guillotine-type knife mechanism moves in a longitudinal direction while cutting perpendicular to the conveyor surface. Dislocation of the fillet is eliminated by synchronizing knife speed with the conveyor, and by overcoming resistance of blade retraction with a retraction mechanism.

Abstract: The present invention provides methods useful in autologous bone marrow transplantation and cancer therapy. According to one aspect of the invention, bone marrow cells from a patient having cancer are treated with selected antisense oligonucleotides in order to deplete the bone marrow of malignant cells prior to infusion back into the bone marrow donor. In a separate embodiment, selected antisense oligonucleotides are administered systemically for anticancer therapy.