Abstract: A method of forming material including alternating layers of fibrin and collagen, formed into tubes, is disclosed for use in repairing transected nerve fibers either by tubulization of the approximated nerve ends, or as an artificial graft which are placed in the severed ends of the nerve, for promotion of nerve growth and regeneration. The new material is treated to reduce antigenicity and is resorbed into the body following regeneration of the nerve fibers.

Abstract: The present invention is directed to prosthesis and methods for promoting nerve regeneration. The proximal and distal ends of a severed nerve are brought into close proximity and are enclosed by a tubular prosthesis. In one preferred embodiment, a epineurial or endoneurial monosuture is used to hold the nerve ends in close proximity. A tight seal is formed between the prosthesis and the injured nerve so as to isolate the injured nerve within the prosthesis from the rest of the body of the host. Additionally, in one preferred embodiment, nerve grafts may be incorporated into the prosthesis and nerve regeneration promoting substances may be incorporated within the nerve graft to further enhance nerve regeneration.

Abstract: The present invention is directed to prostheses and methods for promoting nerve regeneration. The proximal and distal ends of a severed nerve are brought into close proximity and are enclosed by a tubular prosthesis. In one preferred embodiment, a monosuture is used to hold the nerve ends in close proximity. A tight seal is formed between the prosthesis and the injured nerve so as to isolate the injured nerve within the prosthesis from the rest of the body of the host. Additionally, in one preferred embodiment, nerve grafts may be incorporated into the prosthesis and nerve regeneration promoting substances may be incorporated within the nerve graft to further enhance nerve regeneration. Prostheses and methods for inhibiting the formation of neuromas are also disclosed.

Abstract: A package and method of its production, providing a means for transferring soluble phosphorus from a source supply to plant root systems without loss of phosphorus to surrounding soil structure by use of microorganisms. A source of soluble phosphorus is supported along with a plant seed and dormant, plant-beneficial microorganisms within the cell matrix of a cellulosic support device which may be formed into a configuration such as a capsule or ribbon. The cellulosic support device may also contain nutrients for encouraging plant growth upon germination of the plant seed. The fungal inoculum is obtained by propagation of the microorganism in symbiotic association with the root systems of host plants either hydroponically, or in soil, depending upon the microorganism species used. Spores, cryoprotected hyphae and the seed of a vector plant are combined at low temperature with a cellulosic material which is used to form the packages. The formed packages are rapidly freeze-dried, and stored.

Abstract: A primary package, and method of its production, for transferring soluble phosphorus from a secondary package within the primary package to plant root systems without adsorptive loss of phosphorus to surrounding soil constituents.The secondary package contains insoluble rock phosphate particles and a second contingent of microorganisms in a nutrient hydrogen mocroenvironment which allows the microorganisms to act on those phosphate particles to create soluble forms of phosphorus. Alternatively, the secondary package contains granules of commercially refined phosphorus fertilizer packaged to dissolve in a regulated, timed-release fashion.The primary package comprises a cellulosic support device which may be wet, moist or dry, and within which the secondary package is supported along with a vector plant seed or seedling and propagules of primary, plant-beneficial microorganisms. The primary package may be formed into desired configurations and may contain self-adhesive or gel-forming materials.

Abstract: A large first package, and method of its production, for providing soluble plant macronutrients and micronutrients in a timed-release form from a contained second package to an extensive plant community. The bale-like first package comprises a biodegradable cellulosic matrix of municipal waste or other energy-rich organic matter within which the second package is supported. The second package contains insoluble rock mineral and rock phosphate particles and bacterial second microorganisms in a nourishing and hydrated microenvironment which allows the microorganisms to grow, and to produce enzymes and organic acids which act on the mineral particles and thereby create soluble nutrient compounds. Alternatively, the second package contains commercially refined fertilizers packaged to dissolve in a timed-release fashion.The biodegradable package functions as it is introduced onto/into soil in association with vector plants.