Patents by Inventor Larry Li
Larry Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11981740Abstract: Provided herein are BAFF-R antibodies as well as compositions and methods of making and using the same. The antibodies provided herein are, inter alia, useful for the treatment of cancer and autoimmune diseases.Type: GrantFiled: August 16, 2021Date of Patent: May 14, 2024Assignees: CITY OF HOPE, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Hong Qin, Larry W. Kwak, Jingxing Li, Kexin Huang
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Publication number: 20210291136Abstract: Methods and apparatus relate to the synthesis of high fidelity polynucleotides and to the reduction of sequence errors generated during synthesis of nucleic acids on a solid support. Specifically, design of support-bound template oligonucleotides is disclosed. Assembly methods include cycles of annealing, stringent wash and extension of polynucleotides comprising a sequence region complementary to immobilized template oligonucleotides. The error free synthetic nucleic acids generated therefrom can be used for a variety of applications, including synthesis of biofuels and value-added pharmaceutical products.Type: ApplicationFiled: June 7, 2021Publication date: September 23, 2021Applicant: Gen9, Inc.Inventors: Joseph Jacobson, Larry Li-Yang Chu
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Publication number: 20210254052Abstract: Disclosed are methods for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products.Type: ApplicationFiled: April 27, 2021Publication date: August 19, 2021Applicant: Gen9, Inc.Inventors: Joseph Jacobson, George M. Church, Larry Li-Yang Chu
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Patent number: 11071963Abstract: Methods and apparatus relate to the synthesis of high fidelity polynucleotides and to the reduction of sequence errors generated during synthesis of nucleic acids on a solid support. Specifically, design of support-bound template oligonucleotides is disclosed. Assembly methods include cycles of annealing, stringent wash and extension of polynucleotides comprising a sequence region complementary to immobilized template oligonucleotides. The error free synthetic nucleic acids generated therefrom can be used for a variety of applications, including synthesis of biofuels and value-added pharmaceutical products.Type: GrantFiled: March 21, 2018Date of Patent: July 27, 2021Assignee: Gen9, Inc.Inventors: Joseph Jacobson, Larry Li-Yang Chu
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Publication number: 20210207132Abstract: Methods and devices are provided for preparing a protein array having a plurality of proteins. In one embodiment, the method includes providing a plurality of nucleic acids each having a predefined sequence and expressing in vitro a plurality of proteins from the plurality of nucleic acids. In another embodiment, protein arrays having a solid surface and a microvolume are also provided. The solid surface can have a plurality of anchor oligonucleotides capable of hybridizing with a plurality of nucleic acids. The microvolume can cover each of the plurality of anchor oligonucleotides and can be configured to produce a polypeptide from each of the plurality of nucleic acids.Type: ApplicationFiled: March 15, 2021Publication date: July 8, 2021Applicant: Gen9, Inc.Inventors: Joseph Jacobson, Michael E. Hudson, Larry Li-Yang Chu
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Patent number: 11015191Abstract: Disclosed are methods for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products.Type: GrantFiled: November 16, 2017Date of Patent: May 25, 2021Assignee: Gen9, Inc.Inventors: Joseph Jacobson, George Church, Larry Li-Yang Chu
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Patent number: 10982208Abstract: Methods and devices are provided for preparing a protein array having a plurality of proteins. In one embodiment, the method includes providing a plurality of nucleic acids each having a predefined sequence and expressing in vitro a plurality of proteins from the plurality of nucleic acids. In another embodiment, protein arrays having a solid surface and a microvolume are also provided. The solid surface can have a plurality of anchor oligonucleotides capable of hybridizing with a plurality of nucleic acids. The microvolume can cover each of the plurality of anchor oligonucleotides and can be configured to produce a polypeptide from each of the plurality of nucleic acids.Type: GrantFiled: September 23, 2019Date of Patent: April 20, 2021Assignee: Gen9, Inc.Inventors: Joseph Jacobson, Michael E. Hudson, Larry Li-Yang Chu
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Publication number: 20200372792Abstract: A system and method for recording videos of road views of a moving motor vehicle direction of travel, wirelessly uploading the recorded images to a remote server/cloud structure, wirelessly transmitting the recorded video images for display concurrent with the recording. The road view images can be displayed in real time. Also extracting and processing data from the images and displaying such data to a separate vehicle driver. Data may include images of other vehicles, vehicle speeds and distances, objects and object identification and road conditions including weather. Also extracting and processing data from recorded images of camera view of inside the vehicle cabin. System of incentivizing drivers to participate in the vehicle and traffic monitoring, driver performance and distraction detection, voice recognition for hands free operation, automatic vanishing point calibration, video chat/video streaming between vehicles, merchant advertising by location.Type: ApplicationFiled: May 15, 2020Publication date: November 26, 2020Applicant: E-Motion Inc.Inventors: Larry Li, Hannah Li
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Publication number: 20200372791Abstract: A traffic and road condition monitoring system utilizing a vehicle mounted camera recording images of traffic, road conditions ahead of the vehicle wherein the recorded images are uploaded to a component that can distribute the images in real time to remote display components, a transmission component that transmits the image to a remote server in real time as the image is recorded, an image storage component operable with the server, a transmission component operable with the server to transmit real time or stored images to a remote display monitor, and a data processor component to compute distance or speed of objects within the image. The remote display monitor may be positioned in a separate vehicle such as a following vehicle. The traffic images may be shared directly between vehicles in a peer to peer network.Type: ApplicationFiled: May 15, 2020Publication date: November 26, 2020Applicant: E-Motion Inc.Inventors: Larry Li, Hannah Li
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Publication number: 20200181604Abstract: Methods and devices are provided for preparing a protein array having a plurality of proteins. In one embodiment, the method includes providing a plurality of nucleic acids each having a predefined sequence and expressing in vitro a plurality of proteins from the plurality of nucleic acids. In another embodiment, protein arrays having a solid surface and a microvolume are also provided. The solid surface can have a plurality of anchor oligonucleotides capable of hybridizing with a plurality of nucleic acids. The microvolume can cover each of the plurality of anchor oligonucleotides and can be configured to produce a polypeptide from each of the plurality of nucleic acids.Type: ApplicationFiled: September 23, 2019Publication date: June 11, 2020Applicant: Gen9, Inc.Inventors: Joseph Jacobson, Michael E. Hudson, Larry Li-Yang Chu
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Patent number: 10457935Abstract: Methods and devices are provided for preparing a protein array having a plurality of proteins. In one embodiment, the method includes providing a plurality of nucleic acids each having a predefined sequence and expressing in vitro a plurality of proteins from the plurality of nucleic acids. In another embodiment, protein arrays having a solid surface and a microvolume are also provided. The solid surface can have a plurality of anchor oligonucleotides capable of hybridizing with a plurality of nucleic acids. The microvolume can cover each of the plurality of anchor oligonucleotides and can be configured to produce a polypeptide from each of the plurality of nucleic acids.Type: GrantFiled: November 10, 2011Date of Patent: October 29, 2019Assignee: Gen9, Inc.Inventors: Joseph Jacobson, Michael E. Hudson, Larry Li-Yang Chu
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Publication number: 20190143291Abstract: Methods and devices are provided for manipulating droplets on a support using surface tension properties, moving the droplets along a predetermined path and merging two droplets together enabling a number of chemical reactions. Disclosed are methods for controlling the droplets volumes. Disclosed are methods and devices for synthesizing at least one oligonucleotide having a predefined sequence. Disclosed are methods and devices for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides having a predefined sequence.Type: ApplicationFiled: December 21, 2018Publication date: May 16, 2019Inventors: Joseph Jacobson, Larry Li-Yang Chu, Senthil Ramu
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Patent number: 10207240Abstract: Methods and devices are provided for manipulating droplets on a support using surface tension properties, moving the droplets along a predetermined path and merging two droplets together enabling a number of chemical reactions. Disclosed are methods for controlling the droplets volumes. Disclosed are methods and devices for synthesizing at least one oligonucleotide having a predefined sequence. Disclosed are methods and devices for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides having a predefined sequence.Type: GrantFiled: November 3, 2010Date of Patent: February 19, 2019Assignee: Gen9, Inc.Inventors: Joseph Jacobson, Larry Li-Yang Chu, Senthil Ramu
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Publication number: 20180311636Abstract: Methods and apparatus relate to the synthesis of high fidelity polynucleotides and to the reduction of sequence errors generated during synthesis of nucleic acids on a solid support. Specifically, design of support-bound template oligonucleotides is disclosed. Assembly methods include cycles of annealing, stringent wash and extension of polynucleotides comprising a sequence region complementary to immobilized template oligonucleotides. The error free synthetic nucleic acids generated therefrom can be used for a variety of applications, including synthesis of biofuels and value-added pharmaceutical products.Type: ApplicationFiled: March 21, 2018Publication date: November 1, 2018Inventors: Joseph Jacobson, Larry Li-Yang Chu
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Publication number: 20180264427Abstract: Certain aspects of the present invention provide devices and methods for preparing oligonucleotides and for assembling nucleic acid molecules using microfluidic devices.Type: ApplicationFiled: May 11, 2018Publication date: September 20, 2018Inventor: Larry Li-Yang Chu
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Publication number: 20180163200Abstract: Disclosed are methods for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products.Type: ApplicationFiled: November 16, 2017Publication date: June 14, 2018Inventors: Joseph Jacobson, George Church, Larry Li-Yang Chu
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Patent number: 9968902Abstract: Certain aspects of the present invention provide devices and methods for preparing oligonucleotides and for assembling nucleic acid molecules using microfluidic devices.Type: GrantFiled: November 20, 2015Date of Patent: May 15, 2018Assignee: Gen9, Inc.Inventor: Larry Li-Yang Chu
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Patent number: 9925510Abstract: Methods and apparatus relate to the synthesis of high fidelity polynucleotides and to the reduction of sequence errors generated during synthesis of nucleic acids on a solid support. Specifically, design of support-bound template oligonucleotides is disclosed. Assembly methods include cycles of annealing, stringent wash and extension of polynucleotides comprising a sequence region complementary to immobilized template oligonucleotides. The error free synthetic nucleic acids generated therefrom can be used for a variety of applications, including synthesis of biofuels and value-added pharmaceutical products.Type: GrantFiled: November 20, 2015Date of Patent: March 27, 2018Assignee: Gen9, Inc.Inventors: Joseph Jacobson, Larry Li-Yang Chu
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Patent number: 9856471Abstract: Disclosed are methods for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products.Type: GrantFiled: June 27, 2014Date of Patent: January 2, 2018Assignee: Gen9, Inc.Inventors: Joseph Jacobson, George Church, Larry Li-Yang Chu
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Publication number: 20160144333Abstract: Methods and apparatus relate to the synthesis of high fidelity polynucleotides and to the reduction of sequence errors generated during synthesis of nucleic acids on a solid support. Specifically, design of support-bound template oligonucleotides is disclosed. Assembly methods include cycles of annealing, stringent wash and extension of polynucleotides comprising a sequence region complementary to immobilized template oligonucleotides. The error free synthetic nucleic acids generated therefrom can be used for a variety of applications, including synthesis of biofuels and value-added pharmaceutical products.Type: ApplicationFiled: November 20, 2015Publication date: May 26, 2016Inventors: Joseph Jacobson, Larry Li-Yang Chu