Patents by Inventor Larry Ming-Cheung Chow
Larry Ming-Cheung Chow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers
Patent number: 10208025Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.Type: GrantFiled: October 18, 2016Date of Patent: February 19, 2019Assignees: The Hong Kong Polytechnic University, The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Larry Ming Cheung Chow, Tak Hang Chan, Kin Fai Chan, Iris Lai King Wong, Man Chun Law -
Patent number: 10111854Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.Type: GrantFiled: February 6, 2017Date of Patent: October 30, 2018Assignee: The Hong Kong Polytechnic UniversityInventors: Larry Ming-Cheung Chow, Tak Hang William Chan, Kin-Fai Chan, Iris Lai King Wong, Wing-Yiu Kan
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Publication number: 20170143665Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.Type: ApplicationFiled: February 6, 2017Publication date: May 25, 2017Inventors: Larry Ming-Cheung Chow, Tak Hang William Chan, Kin-Fai Chan, Iris Lai King Wong, Wing-Yiu Kan
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Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers
Patent number: 9611256Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.Type: GrantFiled: March 1, 2013Date of Patent: April 4, 2017Assignees: The Hong Kong Polytechnic University, McGill UniversityInventors: Larry Ming Cheung Chow, Tak Hang Chan, Kin Fai Chan, Iris Lai King Wong, Man Chun Law -
ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS
Publication number: 20170044141Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.Type: ApplicationFiled: October 18, 2016Publication date: February 16, 2017Inventors: Larry Ming Cheung Chow, Tak Hang Chan, Kin Fai Chan, Iris Lai King Wong, Man Chun Law -
Patent number: 9562037Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.Type: GrantFiled: February 26, 2015Date of Patent: February 7, 2017Assignee: The Hong Kong Polytechnic UniversityInventors: Larry Ming-Cheung Chow, William Tak Hang Chan, Kin-Fai Chan, Iris Lai King Wong, Wing-Yiu Kan
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Publication number: 20160068503Abstract: A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:Type: ApplicationFiled: September 15, 2015Publication date: March 10, 2016Applicants: THE HONG KONG POLYTECHNIC UNIVERSITY, MCGILL UNIVERSITY, UNIVERSITY OF SOUTH FLORIDA, WAYNE STATE UNIVERSITYInventors: Tak-Hang CHAN, Wai-Har LAM, Larry Ming-Cheung CHOW, Qing Ping DOU, Deborah Joyce KUHN, Aslamuzzaman KAZI, Sheng Biao WAN, Kristin R. LANDIS-PIWOWAR
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Patent number: 9169230Abstract: A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:Type: GrantFiled: March 28, 2014Date of Patent: October 27, 2015Assignees: THE HONG KONG POLYTECHNIC UNIVERSITY, WAYNE STATE UNIVERSITY, UNIVERSITY OF SOUTH FLORIDA, McGILL UNIVERSITYInventors: Tak-Hang Chan, Wai-Har Lam, Larry Ming-Cheung Chow, Qing Ping Dou, Deborah Joyce Kuhn, Aslamuzzaman Kazi, Sheng Biao Wan, Kristin R. Landis-Piwowar
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Publication number: 20150239870Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.Type: ApplicationFiled: February 26, 2015Publication date: August 27, 2015Inventors: Larry Ming-Cheung Chow, William Tak Hang Chan, Kin-Fai Chan, Iris Lai King Wong, Wing-Yiu Kan
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Patent number: 8980848Abstract: This invention relates to bis-flavonoid compounds, their synthesis and use for inhibiting multidrug resistance in chemotherapy and protozoan infection, wherein the bis-flavonoids compounds have the formula:Type: GrantFiled: May 3, 2011Date of Patent: March 17, 2015Assignee: The Hong Kong Polytechnic UniversityInventors: Tak-Hang Chan, Larry Ming-Cheung Chow, Kin-Fai Chan, Iris Lai King Wong
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ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS
Publication number: 20150011513Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.Type: ApplicationFiled: March 1, 2013Publication date: January 8, 2015Inventors: Larry Ming Cheung Chow, Tak Hang Chan, Kin Fai Chan, Iris Lai King Wong, Man Chun Law -
Publication number: 20140213802Abstract: A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:Type: ApplicationFiled: March 28, 2014Publication date: July 31, 2014Applicants: The Hong Kong Polytechnic University, McGill University, University of South Florida, Wayne State UniversityInventors: Tak-Hang CHAN, Wai-Har LAM, Larry Ming-Cheung CHOW, Qing Ping DOU, Deborah Joyce KUHN, Aslamuzzaman KAZI, Sheng Biao WAN, Kristin R. LANDIS-PIWOWAR
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Patent number: 8710097Abstract: Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over-expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered intracellular drug accumulation. A series of flavonoid dimers are developed in this invention, which are linked together by linker groups of various lengths. These flavonoid dimers are found to be efficient P-gp modulators that increase cytotoxicity of anticancer drugs in vitro and dramatically enhance their intracellular drug accumulation. It is found that the flavonoid dimers of this invention is also useful in reducing drug resistance in treating parasitic diseases.Type: GrantFiled: May 9, 2007Date of Patent: April 29, 2014Assignees: The Hong Kong Polytechnic University, McGill UniversityInventors: Tak-Hang Chan, Larry Ming-Cheung Chow
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Patent number: 8710248Abstract: A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:Type: GrantFiled: March 9, 2012Date of Patent: April 29, 2014Assignees: The Hong Kong Polytechnic University, Wayne State University, University of South Florida, McGill UniversityInventors: Tak-Hang Chan, Wai-Har Lam, Larry Ming-Cheung Chow, Qing Ping Dou, Deborah Joyce Kuhn, Aslamuzzaman Kazi, Sheng Biao Wan, Kristin R. Landis-Piwowar
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Publication number: 20130045935Abstract: This invention relates to bis-flavonoid compounds of formula Flavonoid-Linker-Y-Linker-Flavonoid, their synthesis and use for inhibiting multidrug resistance in chemotherapy and protozoan infection.Type: ApplicationFiled: May 3, 2011Publication date: February 21, 2013Inventors: Tak-Hang Chan, Larry Ming-Cheung Chow, Kin-Fai Chan, Iris Lai King Wong
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Publication number: 20120232135Abstract: A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:Type: ApplicationFiled: March 9, 2012Publication date: September 13, 2012Applicants: The Hong Kong Polytechnic University, McGill University, University of South Florida, Wayne State UniversityInventors: Tak-Hang CHAN, Wai-Har Lam, Larry Ming-Cheung Chow, Qing Ping Dou, Deborah Joyce Kuhn, Aslamuzzaman Kazi, Sheng Biao Wan, Kristin R. Landis-Piwowar
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Patent number: 8193377Abstract: (?)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (?)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formulae below, wherein R11, R12, R13, R21, R22, R2, R3, and R4 are each independently selected from the group consisting of —H, and C1 to C10 acyloxyl group; and R5 is selected from the group consisting of —H, C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkynyl, C3-C7-cycloalkyl, phenyl, benzyl and C3-C7-cycloalkenyl, whereas each of the last mentioned 7 groups can be substituted with any combination of one to six halogen atoms; at least one of R11, R12, R13, R21, R22, R2, R3 and R4 is —H, which were found to be more potent than their non-protected counterparts, which can be used as proteasome inhibitors to reduce tumor cell growth.Type: GrantFiled: August 15, 2005Date of Patent: June 5, 2012Assignees: The Hong Kong Polytechnic University, Wayne State University, University of South FloridaInventors: Tak-Hang Chan, Wai-Har Lam, Larry Ming-Cheung Chow, Qing Ping Dou, Deborah Joyce Kuhn, Aslamuzzaman Kazi, Sheng Biao Wan, Kristin R. Landis-Piwowar
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Publication number: 20090197943Abstract: Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over-expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered intracellular drug accumulation. A series of flavonoid dimers are developed in this invention, which are linked together by linker groups of various lengths. These flavonoid dimers are found to be efficient P-gp modulators that increase cytotoxicity of anticancer drugs in vitro and dramatically enhance their intracellular drug accumulation. It is found that the flavonoid dimers of this invention is also useful in reducing drug resistance in treating parasitic diseases.Type: ApplicationFiled: May 9, 2007Publication date: August 6, 2009Applicants: The Hong Kong Polytechnic University, McGill UniversityInventors: Tak-Hang Chan, Larry Ming-Cheung Chow
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Patent number: 7544816Abstract: (?)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (?)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formula 10, wherein R1 is selected from the group of —H and C1 to C6 acyl group; R2, R3, and R4 are each independently selected from the group of —H, —OH, and C1 to C6 acyloxyl group; and at least one of R2, R3, or R4 is —H. The derivatives of (?)-EGCG that is at least as potent as (?)-EGCG. The carboxylate protected forms of (?)-EGCG and its derivatives are found to be more stable than the unprotected forms, which can be used as proteasome inhibitors to reduce tumor cell growth.Type: GrantFiled: August 19, 2004Date of Patent: June 9, 2009Assignees: The Hong Kong Polytechnic University, Wayne State University, University of South Florida, McGill UniversityInventors: Tak-Hang Chan, Wai-Har Lam, Larry Ming-Cheung Chow, Qing Ping Dou, Deborah Joyce Kuhn, Aslamuzzaman Kazi
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Publication number: 20080176931Abstract: (?)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (?)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formulae below, wherein R11, R12, R13, R21, R22, R2, R3, and R4 are each independently selected from the group consisting of —H, and C1 to C10 acyloxyl group; and R5 is selected from the group consisting of —H, C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkynyl, C3-C7-cycloalkyl, phenyl, benzyl and C3 -C7 -cycloalkenyl, whereas each of the last mentioned 7 groups can be substituted with any combination of one to six halogen atoms; at least one of R11, R12, R13, R21, R22, R2, R3 and R4 is —H, which were found to be more potent than their non-protected counterparts, which can be used as proteasome inhibitors to reduce tumor cell growth.Type: ApplicationFiled: August 15, 2005Publication date: July 24, 2008Applicants: The Hong Kong Polytechnic University, Wayne State University, University of South Florida, McGill UniversityInventors: Tak-Hang Chan, Wai-Har Lam, Larry Ming-Cheung Chow, Qing Ping Dou, Deborah Joyce Kuhn, Aslamuzzaman Kazi, Sheng Biao Wan, Kristin R. Landis-Piwowar