Abstract: A system for tracking tumors during radiotherapy for interleaving treatment pulses with imaging pulses is disclosed. The system includes a plurality of multisource scanning eBeam X-ray tubes, each having multiple focal spots. The X-ray tubes are configured to emit X-rays in a plurality of different locations on a target by sequentially emitting the X-rays to the focal spots in the different focal spots. This is done such that the X-rays can be emitted to the plurality of different locations without substantially moving the X-ray tube or the target. The system further includes multiple imager panels configured to act as targets and configured to receive the X-rays from the focal spots of the X-ray tube. The system further includes a tomosynthesis reconstruction module configured to process outputs from the imager panels to construct a unified three-dimensional image that takes information from each of the different imager panels.

Abstract: Methods of obtaining a suspect nodules' sizes and/or growth rate are provided. In one embodiment, the method begins with at a first time: (i) obtaining a first three dimensional (3D) data set cube of voxels of a patient's anatomy including nodules; (ii) creating a second 3D data set cube of the same size as the first where all voxel values are set to zero; (iii) creating multiple Maximum-Intensity-Projection (MIP) images from the first 3D data set cube taken at different angles; (iv) replacing those voxels in the second 3D data set cube with corresponding voxels from the first 3D data set cube that provide non-zero values in the multiple MIP images; and (v) converting data in the second 3D data set cube into closed surface volumes, cross sectional areas or linear dimensions using image segmentation. Data from a second time can be used to determine growth rate.

Abstract: A system for tracking tumors during radiotherapy by interleaving treatment pulses with imaging pulses is disclosed. The system includes a multisource scanning eBeam X-ray tube having a plurality of focal spots. The X-ray tube is configured to emit X-rays to a plurality of different locations on a target by sequentially emitting the X-rays to the focal spots in the plurality of focal spots. This is done such that the X-rays can be emitted to the plurality of different locations on the target without substantially moving the X-ray tube or the target. The system further includes an imager panel configured to act as the target and configured to receive the X-rays from the focal spots of the X-ray tube. The system further includes a tomosynthesis reconstruction module configured to process output from the imager panel to construct an image.

Abstract: A system for tracking tumors during radiotherapy for interleaving treatment pulses with imaging pulses is disclosed. The system includes a plurality of multisource scanning eBeam X-ray tubes, each having multiple focal spots. The X-ray tubes are configured to emit X-rays in a plurality of different locations on a target by sequentially emitting the X-rays to the focal spots in the different focal spots. This is done such that the X-rays can be emitted to the plurality of different locations without substantially moving the X-ray tube or the target. The system further includes multiple imager panels configured to act as targets and configured to receive the X-rays from the focal spots of the X-ray tube. The system further includes a tomosynthesis reconstruction module configured to process outputs from the imager panels to construct a unified three-dimensional image that takes information from each of the different imager panels.

Abstract: An x-ray imaging device may include a detector array and an x-ray converting layer coupled to the detector array. The detector array and the x-ray converting layer may be configured such that x-rays traverse the detector array before propagating in the x-ray converting layer. The x-ray imaging device may also include a buildup layer behind the x-ray converting layer. The x-ray imaging device may be used as a “universal” imager for both MV and kV imaging.

Abstract: Techniques described herein generally relate to identifying, assessing, and managing cancer growth rates and potential metastasis.

Abstract: An x-ray imaging device may include a detector array and an x-ray converting layer coupled to the detector array. The detector array and the x-ray converting layer may be configured such that x-rays traverse the detector array before propagating in the x-ray converting layer. The x-ray imaging device may also include a buildup layer behind the x-ray converting layer. The x-ray imaging device may be used as a “universal” imager for both MV and kV imaging.

Abstract: A system for tracking tumors during radiotherapy for interleaving treatment pulses with imaging pulses is disclosed. The system includes a multisource scanning eBeam X-ray tube having a plurality of focal spots. The X-ray tube is configured to emit X-rays in a plurality of different locations on a target by sequentially emitting the X-rays to the focal spots in the plurality of focal spots. This is done such that the X-rays can be emitted to the plurality of different locations without substantially moving the X-ray tube or the target. The system further includes an imager panel configured to act as the target and configured to receive the X-rays from the focal spots of the X-ray tube. The system further includes a tomosynthesis reconstruction module configured to process output from the imager panel to construct an image.

Abstract: A method for use in a medical procedure includes obtaining a contrast-enhanced image of a portion of a patient, the portion of the patient having an object, obtaining a non-contrast-enhanced image of the portion, wherein the contrast-enhanced image and the non-contrast-enhanced image are created at different times, and determining a position of the object using the contrast-enhanced image and the non-contrast-enhanced image. A method for use in a medical procedure includes obtaining a contrast-enhanced image of a portion of a patient, the portion of the patient having an object, obtaining a non-contrast-enhanced image of the portion, and determining a position of the object using the contrast-enhanced image and the non-contrast-enhanced image, wherein the act of determining the position is performed is substantially real time.

Abstract: Techniques described herein generally relate to identifying, assessing, and managing cancer growth rates and potential metastasis.

Abstract: Portions of the radiation source are obscured so that the radiation only passes through the specific areas of the patient related to the regions-of-interest to the doctor. Scattered radiation received by detector pixels that are obscured by direct-line of sight radiation are used to estimate the scattered radiation in the un-obscured portion, which can be used to increase the accuracy of the image taken through the un-obscured portion.

Abstract: Improved corrosion resistance for direct X-ray imaging detectors is obtained by providing a pixelated, electrically conductive barrier layer between the X-ray sensitive material and the pixel electrodes. Each barrier layer can cover part or all of its corresponding pixel electrode. In cases where pixel electrodes makes contact to underlying circuitry through vertical vias, it is preferred for the barrier layers to cover the via sections of the pixel electrodes. The barrier layers for each pixel electrode can be spaced apart from each other, or they can all be included within a continuous film on top of the pixel electrodes. Such a continuous film can be pixelated by spatially modulating its properties (e.g., thickness, doping) to significantly reduce lateral conductivity from pixel to pixel.

Abstract: Disclosed are methods, systems, and computer-product programs for increasing accuracy in cone-beam computed tomography.

Abstract: A method of analyzing a volumetric data set obtained by an imaging system from an object is provided includes defining a first region of interest comprising a population of voxels of a first tissue part of the object to obtain a first distribution of radiation attenuation coefficient values, defining a second region of interest comprising a sample of voxels of a second tissue part of the object to obtain a second distribution of radiation attenuation coefficient values, and distinguishing the second tissue from the first tissue using the properties of the first and second distributions of radiation attenuation coefficients.

Abstract: Disclosed are methods, systems, and computer-product programs for increasing accuracy in cone-beam computed tomography (CBCT) by obscuring portions of the radiation source so that the radiation only passes through the specific areas of the patient related to the regions-of-interest to the doctor. The obscuring action causes less radiation scattering to occur in the patient's body, thereby reducing a major source of error in the image accuracy caused by scattered radiation. Scattered radiation received by detector pixels that are obscured by direct-line of sight radiation may be used to estimate the scattered radiation in the un-obscured portion, which can be used to further increase the accuracy of the image.

Abstract: A radiation projection detector includes a conversion layer configured to generate light photons in response to a radiation, the conversion layer having a plurality of first conversion elements and a plurality of second conversion elements, and a photo detector array aligned with the conversion panel, wherein each of the first conversion elements has a first radiation conversion characteristic, and each of the second conversion elements has a second radiation conversion characteristic. A radiation projection detector includes a photoconductor layer configured to generate charges in response to radiation, the photoconductor layer having a plurality of first photoconductor elements and a plurality of second photoconductor elements, and a detector array aligned with the photoconductor layer, wherein each of the first photoconductor elements has a first charge generating characteristic, and each of the second photoconductor elements has a second charge generating characteristic.

Abstract: A method of generating images of a portion of a body includes introducing a contrast agent into the body, generating a first set of image data using radiation at a first energy level after the contrast agent is introduced into the body, generating a second set of image data using radiation at a second energy level after the contrast agent is introduced into the body, and creating a volumetric composite image using the first and the second sets of image data.

Abstract: A method for use in a medical procedure includes obtaining a contrast-enhanced image of a portion of a patient, the portion of the patient having an object, obtaining a non-contrast-enhanced image of the portion, wherein the contrast-enhanced image and the non-contrast-enhanced image are created at different times, and determining a position of the object using the contrast-enhanced image and the non-contrast-enhanced image. A method for use in a medical procedure includes obtaining a contrast-enhanced image of a portion of a patient, the portion of the patient having an object, obtaining a non-contrast-enhanced image of the portion, and determining a position of the object using the contrast-enhanced image and the non-contrast-enhanced image, wherein the act of determining the position is performed is substantially real time.

Abstract: A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.

Abstract: Disclosed are methods, systems, and computer-product programs for increasing accuracy in cone-beam computed tomography.