Patents by Inventor Larry R. Cruthers

Larry R. Cruthers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fasciolicidal compositions
    Patent number: 4173632
    Abstract: Anthelmintic compositions which are especially useful for their fasciolicidal activity are provided and are formed of a synergistic combination of 5(6)-lower alkylbenzimidazol carbamates, such as (5-butyl-1H-benzimidazol-2-yl)carbamic acid, methyl ester, and 3,5-dibromo-N-(4-bromophenyl)-2-hydroxybenzamide(tribromosalan) alone or in admixture with 4',5-dibromosalicylanilide and/or 3,5-dibromosalicylanilide.
    Type: Grant
    Filed: July 31, 1978
    Date of Patent: November 6, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Larry R. Cruthers, Terrence M. James, Sidney Goff, Antoine R. Alouche
  • Method of treating helminthiasis by parenteral administration of sulfoxide derivatives of benzimidazoles
    Patent number: 4145433
    Abstract: A method is provided for treating or inhibiting helminthiasis by parenterally or topically administering sulfoxide derivatives of benzimidazoles having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, R.sup.2 and R.sup.3 may be the same or different and are hydrogen or lower alkyl, R.sup.4 and R.sup.5 may be the same or different and are hydrogen, lower alkyl, lower alkoxy, halogen or nitro, and m is 0 to 3, n is 0 to 3, m + n being .ltoreq. 5. Pharmaceutical compositions for use in the above method are also provided.
    Type: Grant
    Filed: January 18, 1978
    Date of Patent: March 20, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Larry R. Cruthers
  • Method of treating helminthiasis by parenteral administration of sulfide- and sulfoxide-derivatives of benzimidazoles
    Patent number: 4145431
    Abstract: A method is provided for treating or inhibiting helminthiasis by parenterally or topically administering sulfide or sulfoxide derivatives of benzimidazoles having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, R.sup.2 and R.sub.3 may be the same or different and are hydrogen or lower alkyl, Z is ##STR2## or R.sup.4 --C.tbd.C--, R.sup.4, R.sup.5 and R.sup.6 may be the same or different and are hydrogen, lower alkyl, or phenyl, and m is 0 to 3, n is 0 to 3, m + n being .ltoreq. 5, and p is 0 or 1. Pharmaceutical compositions for use in the above method are also provided.
    Type: Grant
    Filed: February 16, 1978
    Date of Patent: March 20, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Larry R. Cruthers
  • 2,2-Dihalo-1(3)-lower alkyl-cyclopropylalkylthio benzimidazole derivatives, compositions thereof and method of use in treating tapeworms and whipworms
    Patent number: 4138493
    Abstract: Benzimidazole derivatives are provided having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, R.sup.2 and R.sup.3 are the same or different and are hydrogen or lower alkyl, R.sup.4 is lower alkyl or phenyl, and R.sup.5 and R.sup.6 are the same or different and are chlorine, bromine, fluorine or iodine, m is 0 to 3, n is 0 to 3, and m + n is .ltoreq. 5, and physiologically acceptable salts thereof. These compounds are especially useful in treating or preventing tapeworm and whipworm infestation in mammalian species or poultry.
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: February 6, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Larry R. Cruthers, Barbara V. Maurer
  • Method for treating blackhead disease
    Patent number: 4127664
    Abstract: A method is provided for treating or preventing blackhead disease in birds by administering to birds, especially to poultry, such as turkeys, benzimidazoles having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, and R.sup.2 is lower alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, phenyl, benzyl and phenylethyl dispersed in a non-toxic physiologically acceptable carrier.
    Type: Grant
    Filed: November 11, 1977
    Date of Patent: November 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Larry R. Cruthers
  • Sulfoxide derivatives of benzimidazoles
    Patent number: 4093732
    Abstract: Sulfoxide derivatives of benzimidazoles are provided having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, R.sup.2 and R.sup.3 may be the same or different and are hydrogen or lower alkyl, R.sup.4 is alkylcycloalkyl, halocycloalkyl or cycloalkenyl, and m is 0 to 3, n is 0 to 3, m + n being < 5. These compounds are useful as anthelmintic agents.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: June 6, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Larry R. Cruthers
  • Method of treating helminthiasis by parenteral or topical administration of sulfoxide derivatives of benzimidazoles
    Patent number: 4076825
    Abstract: A method is provided for treating or inhibiting helminthiasis by parenterally or topically administering sulfoxide derivatives of benzimidazoles having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, and R.sup.2 is lower alkyl. Pharmaceutical compositions for use in the above method are also provided.
    Type: Grant
    Filed: June 22, 1977
    Date of Patent: February 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Larry R. Cruthers
  • Method of treating helminthiasis by parenteral administration of sulfoxide derivatives of benzimidazoles
    Patent number: 4076828
    Abstract: A method is provided for treating or inhibiting helminthiasis by parenterally administering sulfoxide derivatives of benzimidazoles having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, R.sup.2 and R.sup.3 may be the same or different and are hydrogen or lower alkyl, R.sup.4 is cycloalkyl, and m is 0 to 3, n is 0 to 3, m + n being .ltoreq. 5. Pharmaceutical compositions for use in the above method are also provided.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: February 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Larry R. Cruthers
  • Method of treating helminthiasis by parenteral administration of sulfoxide derivatives of benzimidazoles
    Patent number: 4076827
    Abstract: A method is provided for treating or inhibiting helminthiasis by parenterally administering sulfoxide derivatives of benzimidazoles having the structure ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, and R.sup.2 is hydrogen, lower alkyl, halogen, lower alkoxy or nitro. Pharmaceutical compositions for use in the above method are also provided.
    Type: Grant
    Filed: April 28, 1977
    Date of Patent: February 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Larry R. Cruthers