Patents by Inventor Larry R. McLean

Larry R. McLean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic peptide lung surfactants having covalently bonded antioxidants
    Patent number: 5886156
    Abstract: Synthetic pulmonary surfactants having antioxidant properties consisting of a complex of a polypeptide of 3-4 amino acid residues, with an antioxidant moiety, and a lipid consisting of one or more of the lipids associated with natural pulmonary surfactant were prepared. These surfactants are useful in the treatment of respiratory distress syndrome.
    Type: Grant
    Filed: December 26, 1996
    Date of Patent: March 23, 1999
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Larry R. McLean, J. Vincent Edwards
  • Peptide lung surfactants and therapeutic combinations
    Patent number: 5861481
    Abstract: Synthetic pulmonary surfactant consisting of a complex of a polypeptide of 3-4 amino acid residues having alpha-helical structure and a covalently bound long chain acyl group. The peptides are useful when consisting of one or more associated lipids in combination in conditions associated with respiratory distress.
    Type: Grant
    Filed: May 8, 1997
    Date of Patent: January 19, 1999
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Larry R. McLean, J. Vincent Edwards
  • Synthetic lung surfactant having antioxidant properties
    Patent number: 5683982
    Abstract: Synthetic pulmonary surfactants having antioxidant properties consisting of a complex of a polypeptide, with an antioxidant moiety, having an alpha-helical structure and a lipid consisting of one or more of the lipids associated with natural pulmonary surfactant were prepared. These surfactants are useful in the treatment of respiratory distress syndrome.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: November 4, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Larry R. McLean, Marguerite H. Payne
  • Synthetic peptide lung surfactants having covalently bonded antioxidants
    Patent number: 5623052
    Abstract: Synthetic pulmonary surfactants having antioxidant properties consisting of a complex of a polypeptide of 3-4 amino acid residues, with an antioxidant moiety, and a lipid consisting of one or more of the lipids associated with natural pulmonary surfactant were prepared. These surfactants are useful in the treatment of respiratory distress syndrome.
    Type: Grant
    Filed: July 14, 1995
    Date of Patent: April 22, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Larry R. McLean, J. Vincent Edwards
  • Synthetic lung surfactant having antioxidant properties
    Patent number: 5272252
    Abstract: Synthetic pulmonary surfactants having antioxidant properties consisting of a complex of a polypeptide, with an antioxidant moiety, having an alpha-helical structure and a lipid consisting of one or more of the lipids associated with natural pulmonary surfactant were prepared. These surfactants are useful in the treatment of respiratory distress syndrome.
    Type: Grant
    Filed: November 4, 1991
    Date of Patent: December 21, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Larry R. McLean, Marquerite H. Payne