Abstract: A method of making replicate arrays, comprises repeatedly sectioning a bundle of aligned array members to make wafers comprising replicate arrays, wherein: each array comprises structural members each of which has a lumen therethrough which is continuously enclosed thereby; each array member is a homogenous composition disposed within a separate lumen of a structural member which extends from a first to a second wafer surface formed by said sectioning; and each structural member and each array member are aligned in the bundle parallel to an alignment axis and occupy a defined position in the two dimensions orthogonal thereto; wherein the array members comprise analyte binding reagents that hybridize to DNA or RNA having specific nucleotide sequences.

Abstract: An invention that relates to arrays, to methods and devices for producing arrays and to methods and devices for using arrays is described. In a particular aspect the invention relates to methods in which array members are aligned in a bundle and the bundle then is sectioned across the alignment to produce replicate arrays. In a further particular aspect the invention relates to arrays of analyte binding reagents. In another particular aspect the invention relates to micro-arrays.