Patents by Inventor Larry Takiff
Larry Takiff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220235075Abstract: Voltage sensitive dyes comprising boron and related compositions and methods are provided. In some embodiments, a voltage sensitive dye comprises an electron acceptor comprising boron. The electron acceptor may be attached (e.g., covalently) to at least one electron donating group and at least one polar group. For instance, the electron acceptor may comprise optionally substituted boron dipyrromethene (e.g., optionally substituted 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene). The point of attachment and chemical nature of the electron donating group(s) and polar group(s) may be selected to impart beneficial properties to the voltage sensitive dye. For instance, the voltage sensitive dye may have an extended difference in the dipole moment between the ground and electronic states due at least in part to the position of the electron donating group(s).Type: ApplicationFiled: March 31, 2022Publication date: July 28, 2022Applicant: Akita Innovations LLCInventors: Kevin M. Bardon, Richard A. Minns, Scott D. Selfridge, Larry Takiff, Timothy Adams
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Patent number: 11332484Abstract: Voltage sensitive dyes comprising boron and related compositions and methods are provided. In some embodiments, a voltage sensitive dye comprises an electron acceptor comprising boron. The electron acceptor may be attached (e.g., covalently) to at least one electron donating group and at least one polar group. For instance, the electron acceptor may comprise optionally substituted boron dipyrromethene (e.g., optionally substituted 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene). The point of attachment and chemical nature of the electron donating group(s) and polar group(s) may be selected to impart beneficial properties to the voltage sensitive dye. For instance, the voltage sensitive dye may have an extended difference in the dipole moment between the ground and electronic states due at least in part to the position of the electron donating group(s).Type: GrantFiled: March 2, 2018Date of Patent: May 17, 2022Assignee: Akita Innovations LLCInventors: Kevin M. Bardon, Richard A. Minns, Scott D. Selfridge, Larry Takiff, Timothy Adams
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Publication number: 20220099540Abstract: Methods and systems for assessing membrane potential are provided. In some embodiments, the methods and systems, described herein, may allow spatial patterns of membrane potential to be facilely obtained. For instance, a method may comprise transferring a population of cells from a tissue to a substrate. The transfer process may substantially maintain the viability of and/or the spatial relationship between the cells. The cells on the membrane may be exposed to a voltage sensitive dye. The dye may allow the membrane potential of individual cells on the substrate to be imaged or otherwise detected. The individual cell membrane potentials when imaged together on the substrate may form a spatial membrane potential pattern. The spatial membrane potential pattern may be used to assess one or more physiological characteristics of the cells. The methods and systems may be used for a wide variety of applications, including the assessment of biopsies.Type: ApplicationFiled: March 20, 2020Publication date: March 31, 2022Applicant: Ion Diagnostics LLCInventors: Dany Adams, Larry Takiff, Sandra Gaston
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Publication number: 20200362193Abstract: Anti-fog coatings and related articles, compositions, and methods are generally described. In some embodiments, an article may comprise a dual functional anti-fog and anti-fouling coating. The coating may be stimuli-responsive and the surface energy, and accordingly wettability, of the coating may reversibly change upon exposure to certain conditions. For instance, upon exposure to water, the coating may have a relatively high surface energy that allows water to wet the coating. Conversely, exposure to an oil may cause the coating to have a relatively low surface energy that repels the oil. In some embodiments, such a stimuli responsive coating may comprise a cross-linked polymer network with covalently attached oleophobic groups.Type: ApplicationFiled: March 20, 2020Publication date: November 19, 2020Applicant: Akita Innovations LLCInventors: Larry Takiff, Richard A. Minns, Matthew Easterbrooks
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Publication number: 20200071342Abstract: Voltage sensitive dyes comprising boron and related compositions and methods are provided. In some embodiments, a voltage sensitive dye comprises an electron acceptor comprising boron. The electron acceptor may be attached (e.g., covalently) to at least one electron donating group and at least one polar group. For instance, the electron acceptor may comprise optionally substituted boron dipyrromethene (e.g., optionally substituted 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene). The point of attachment and chemical nature of the electron donating group(s) and polar group(s) may be selected to impart beneficial properties to the voltage sensitive dye. For instance, the voltage sensitive dye may have an extended difference in the dipole moment between the ground and electronic states due at least in part to the position of the electron donating group(s).Type: ApplicationFiled: March 2, 2018Publication date: March 5, 2020Applicant: Akita Innovations LLCInventors: Kevin M. Bardon, Richard A. Minns, Scott D. Selfridge, Larry Takiff, Timothy Adams
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Patent number: 8968875Abstract: The embodiments described herein generally relate to compositions and articles including dye compounds having desirable optical properties, and related methods. In some cases, the compositions and articles may possess advantageous optical properties, including various degrees of absorbance, emission, and/or transmission at particular wavelengths or ranges of wavelength. Embodiments described herein may be useful as optical filters in protective eyewear applications.Type: GrantFiled: March 21, 2012Date of Patent: March 3, 2015Inventors: Larry Takiff, Kevin M. Bardon, Charles Lysogorski, Oliver Pentenrieder
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Publication number: 20130249137Abstract: The embodiments described herein generally relate to methods for incorporating dye compounds into various polymer materials. In some cases, organic solvents having high boiling points may be utilized to dissolve, disperse, or suspend dye compounds which may then be applied to a polymer material.Type: ApplicationFiled: March 21, 2012Publication date: September 26, 2013Applicant: Revision Military, Ltd.Inventors: Larry Takiff, Oliver Pentenrieder
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Publication number: 20130252000Abstract: The embodiments described herein generally relate to compositions and articles including dye compounds having desirable optical properties, and related methods. In some cases, the compositions and articles may possess advantageous optical properties, including various degrees of absorbance, emission, and/or transmission at particular wavelengths or ranges of wavelength. Embodiments described herein may be useful as optical filters in protective eyewear applications.Type: ApplicationFiled: March 21, 2012Publication date: September 26, 2013Applicant: Revision Military, Ltd.Inventors: Larry Takiff, Kevin M. Bardon, Charles Lysogorski, Oliver Pentenrieder
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Patent number: 8486311Abstract: The embodiments described herein generally relate to compositions and articles including dye compounds having desirable optical properties, and related methods. In some cases, the compositions and articles may possess advantageous optical properties, including various degrees of absorbance, emission, and/or transmission at particular wavelengths or ranges of wavelength. Embodiments described herein may be useful as optical filters in protective eyewear applications.Type: GrantFiled: March 21, 2012Date of Patent: July 16, 2013Assignee: Revision Military, Ltd.Inventors: Larry Takiff, Kevin M. Bardon, Charles Lysogorski, Oliver Pentenrieder
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Publication number: 20080044737Abstract: Disclosed is a photopolymerizable holographic recording medium for data storage that comprises colloidal metal, and which exhibits a threshold for a second stage polymerization which is substantially insensitive to the light used for both forming holograms and interrogating the medium during servo and/or read events. Also disclosed is a method of preparing said photopolymerizable holographic recording medium. Also disclosed is a method for preparing a colloidal without additives in a viscous medium.Type: ApplicationFiled: October 16, 2007Publication date: February 21, 2008Applicant: Aprilis, Inc.Inventors: Erdem Cetin, Richard Ingwall, Richard Minns, David Waldman, Larry Takiff
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Publication number: 20060194016Abstract: Methods and apparatus for making optically readable storage media in which reading beam passes through bonding layer configured with reactive material that transforms from optically transparent state to optically opaque state after exposure to predefined stimulus, thereby inhibiting access to data encoded on optically readable storage media. The method includes steps of synthesizing blocked dye, combining the blocked dye with carrier material, curing the resultant combination, deblocking dye to produce a reduced dye in the resultant bonding layer, exposing optically readable storage media with the reactive material in its bonding layer to predetermined stimulus. A further aspect includes optically readable storage media wherein reading light passes through bonding layer and data encoded information is encoded on L1 substrate. Another aspect includes processes for making optically readable storage media with at least two mechanisms for limiting access to encoded data of the optically readable storage media.Type: ApplicationFiled: November 14, 2005Publication date: August 31, 2006Applicant: FlexPlay Technologies, Inc.Inventors: Edward Lindholm, Louis Cincotta, Larry Takiff, Richard Minns
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Patent number: 7026029Abstract: Methods and apparatus are provided for making an optically readable storage media in which the reading beam passes through a bonding layer configured with a reactive material that transforms from an optically transparent state to an optically opaque state after exposure to a predefined stimulus, thereby inhibiting access to the data encoded on the optically readable storage media. The method includes steps of synthesizing a blocked dye combining the blocked dye with a carrier material curing the resultant combination deblocking the dye to produce a reduced dye in the resultant bonding layer exposing the optically readable storage media with the reactive material in its bonding layer to a predetermined stimulus. In a further aspect of the present invention methods and apparatus are provided for making an optically readable storage media wherein the reading light passes through the bonding layer and the data encoded information is encoded on the L1 substrate.Type: GrantFiled: August 29, 2003Date of Patent: April 11, 2006Inventors: Edward P. Lindholm, Louis Cincotta, Richard A. Minns, Larry Takiff
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Patent number: 6960382Abstract: Methods and apparatus are provided for making an optically readable storage media in which the reading beam passes through a bonding layer configured with a reactive material that transforms from an optically transparent state to an optically opaque state after exposure to a predefined stimulus, thereby inhibiting access to the data encoded on the optically readable storage media. The method includes steps of synthesizing a blocked dye combining the blocked dye with a carrier material curing the resultant combination deblocking the dye to produce a reduced dye in the resultant bonding layer exposing the optically readable storage media with the reactive material in its bonding layer to a predetermined stimulus. In a further aspect of the present invention methods and apparatus are provided for making an optically readable storage media wherein the reading light passes through the bonding layer and the data encoded information is encoded on the L1 substrate.Type: GrantFiled: May 3, 2004Date of Patent: November 1, 2005Assignee: FlexPlay Technologies, Inc.Inventors: Robert F. Thompson, Neil Exter, Yannis Bakos, Richard A. Minns, Larry Takiff
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Publication number: 20040209034Abstract: Methods and apparatus are provided for making an optically readable storage media in which the reading beam passes through a bonding layer configured with a reactive material that transforms from an optically transparent state to an optically opaque state after exposure to a predefined stimulus, thereby inhibiting access to the data encoded on the optically readable storage media. The method includes steps of synthesizing a blocked dye combining the blocked dye with a carrier material curing the resultant combination deblocking the dye to produce a reduced dye in the resultant bonding layer exposing the optically readable storage media with the reactive material in its bonding layer to a predetermined stimulus. In a further aspect of the present invention methods and apparatus are provided for making an optically readable storage media wherein the reading light passes through the bonding layer and the data encoded information is encoded on the L1 substrate.Type: ApplicationFiled: May 3, 2004Publication date: October 21, 2004Applicant: Flexplay Technologies, Inc.Inventors: Robert F. Tompson, Neil Exter, Yannis Bakos, Richard A. Minns, Larry Takiff
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Publication number: 20040137188Abstract: Methods and apparatus are provided for making an optically readable storage media in which the reading beam passes through a bonding layer configured with a reactive material that transforms from an optically transparent state to an optically opaque state after exposure to a predefined stimulus, thereby inhibiting access to the data encoded on the optically readable storage media. The method includes steps of synthesizing a blocked dye combining the blocked dye with a carrier material curing the resultant combination deblocking the dye to produce a reduced dye in the resultant bonding layer exposing the optically readable storage media with the reactive material in its bonding layer to a predetermined stimulus. In a further aspect of the present invention methods and apparatus are provided for making an optically readable storage media wherein the reading light passes through the bonding layer and the data encoded information is encoded on the L1 substrate.Type: ApplicationFiled: August 29, 2003Publication date: July 15, 2004Inventors: Edward P. Lindholm, Louis Cincotta, Richard A. Minns, Larry Takiff
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Patent number: 6756103Abstract: Methods and apparatus are provided for making an optically readable storage media in which the reading beam passes through a bonding layer configured with a reactive material that transforms from an optically transparent state to an optically opaque state after exposure to a predefined stimulus, thereby inhibiting access to the data encoded on the optically readable storage media. The method includes steps of synthesizing a blocked dye combining the blocked dye with a carrier material curing the resultant combination deblocking the dye to produce a reduced dye in the resultant bonding layer exposing the optically readable storage media with the reactive material in its bonding layer to a predetermined stimulus. In a further aspect of the present invention methods and apparatus are provided for making an optically readable storage media wherein the reading light passes through the bonding layer and the data encoded information is encoded on the L1 substrate.Type: GrantFiled: June 5, 2002Date of Patent: June 29, 2004Assignee: Flexplay Technologies, Inc.Inventors: Robert F. Thompson, Neil Exter, Yannis Bakos, Richard A. Minns, Larry Takiff
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Publication number: 20030198892Abstract: A limited play optical storage medium for data is provided which comprises a first optically transparent substrate; a reflective layer; a data layer disposed between said substrate and said reflective layer; a reactive layer that optionally comprises a polyhydroxy compound, at least one carrier, and at least one reactive material; and a second substrate wherein the second substrate is optionally a light-absorbing layer with the proviso that the storage medium includes a reactive layer with a polyhydroxy compound, a light-absorbing layer, or a combination thereof.Type: ApplicationFiled: March 18, 2003Publication date: October 23, 2003Applicant: General Electric CompanyInventors: Karin Ann Ezbiansky, Daniel Robert Olson, Philippe Schottland, Larry Takiff, Verghese Thomas, Marc Brian Wisnudel
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Publication number: 20030129408Abstract: Methods and apparatus are provided for making an optically readable storage media in which the reading beam passes through a bonding layer configured with a reactive material that transforms from an optically transparent state to an optically opaque state after exposure to a predefined stimulus, thereby inhibiting access to the data encoded on the optically readable storage media. The method includes steps of synthesizing a blocked dye combining the blocked dye with a carrier material curing the resultant combination deblocking the dye to produce a reduced dye in the resultant bonding layer exposing the optically readable storage media with the reactive material in its bonding layer to a predetermined stimulus. In a further aspect of the present invention methods and apparatus are provided for making an optically readable storage media wherein the reading light passes through the bonding layer and the data encoded information is encoded on the L1 substrate.Type: ApplicationFiled: June 5, 2002Publication date: July 10, 2003Inventors: Robert F. Thompson, Neil Exter, Yannis Bakos, Richard A. Minns, Larry Takiff