Patents by Inventor Larry W. Hertel

Larry W. Hertel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2',3'-dideoxy-2',2'-difluoronucleosides and intermediates
    Patent number: 5644043
    Abstract: This invention provides 2',3'-dideoxy-2',2'-difluoronucleosides of the structure ##STR1## wherein R.sup.1 -R.sup.4 are defined in the specification. These compounds have been shown to be useful for treating a variety of vital infections in experimental animals as well as having antineoplastic activity against various mouse tumors.
    Type: Grant
    Filed: December 27, 1993
    Date of Patent: July 1, 1997
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Julian S. Kroin
  • Anomeric fluororibosyl amines
    Patent number: 5594155
    Abstract: Anomeric 2,2-difluororibosyl azide and amine intermediates which are useful for the preparation of 2'-deoxynucleosides, and processes thereto, are provided. Processes for preparing 2'-deoxynucleosides also are provided.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: January 14, 1997
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Charles D. Jones, Julian S. Kroin, Thomas E. Mabry
  • Methods of treatment using 2',3'-dideoxy-2',2'-difluoronucleosides
    Patent number: 5574021
    Abstract: 2',3'-Dideoxy-2',2'-difluoronucleosides are useful for treating susceptible neoplasms and viral infections in mammals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: November 12, 1996
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Julian S. Kroin
  • Anomeric fluororibosyl amines
    Patent number: 5541345
    Abstract: Anomeric 2,2-difluororibosyl azide and amine intermediates which are useful for the preparation of 2'-deoxynucleosides, and processes thereto, are provided. Processes for preparing 2'-deoxynucleosides also are provided.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: July 30, 1996
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Charles D. Jones, Julian S. Kroin, Thomas E. Mabry
  • Anomeric fluororibosyl amines
    Patent number: 5480992
    Abstract: Anomeric 2,2-difluororibosyl azide and amine intermediates which are useful for the preparation of 2'-deoxynucleosides, and processes thereto, are provided. Processes for preparing 2'-deoxynucleosides also are provided.
    Type: Grant
    Filed: September 16, 1993
    Date of Patent: January 2, 1996
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Charles D. Jones, Julian S. Kroin, Thomas E. Mabry
  • Method of treating tumors in mammals with 2',2'-difluoronucleosides
    Patent number: 5464826
    Abstract: A method of treating susceptible neoplasms in mammals comprising administering to a mammal in need of such treatment a pharmaceutically effective amount of a compound of the formula ##STR1## wherein: R.sup.1 is hydrogen;R.sup.2 is a base defined by one of the formulae ##STR2## X is C-R.sup.4 ; R.sup.3 is hydrogen;R.sup.4 is hydrogen, C.sub.1 -C.sub.4 alkyl, bromo, fluoro, chloro or iodo;and the pharmaceutically-acceptable salts thereof.
    Type: Grant
    Filed: July 26, 1994
    Date of Patent: November 7, 1995
    Assignee: Eli Lilly and Company
    Inventors: Gerald B. Grindey, Larry W. Hertel
  • Difluro antivirals and intermediate therefor
    Patent number: 5118820
    Abstract: A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.
    Type: Grant
    Filed: February 7, 1991
    Date of Patent: June 2, 1992
    Assignee: Eli Lilly and Company
    Inventor: Larry W. Hertel
  • 2-deoxy-2',2'-difluoro-inosine and 5'O-derivatives
    Patent number: 5061793
    Abstract: 2'-deoxy-2',2'-difluoro-inosine and 5'-O alkyl derivatives are disclosed as inhibitors of neoplasms.
    Type: Grant
    Filed: March 3, 1988
    Date of Patent: October 29, 1991
    Assignee: Eli Lilly and Company
    Inventors: Gerald B. Grindey, Larry W. Hertel
  • Difluoro antivirals and intermediate therefor
    Patent number: 5015743
    Abstract: A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.
    Type: Grant
    Filed: December 15, 1989
    Date of Patent: May 14, 1991
    Assignee: Eli Lilly and Company
    Inventor: Larry W. Hertel
  • Inversion of 2,2-difluororibose to a 2,2-difluoroxylose and intermediates therefor
    Patent number: 4983724
    Abstract: A process and intermediates useful for the invrsion of 2-deoxy-2,2-difluororibose analogs to provide 2-deoxy-2,2-difluoroxylose analogs is described.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: January 8, 1991
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Marie T. Reamer
  • Method of preparing beta-2',2'-difluoronucleosides
    Patent number: 4914028
    Abstract: A process for preparing .beta.-2',2'-difluoronucleosides, and a novel intermediate thereto, are disclosed.
    Type: Grant
    Filed: February 10, 1988
    Date of Patent: April 3, 1990
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Cora Sue Grossman, Julian S. Kroin
  • Photochemical conversion of cephalosporins, 1-carba(1-dethia)cephalosporins and 1-oxa(1-dethia)cephalosporins
    Patent number: 4888100
    Abstract: A process for photochemically converting 3-exomethylene cephams (or 1-carba(1-dethia)cephams or and 1-oxa(1-dethia)cephams) from the corresponding 3-alkyl-3-cephem (or 1-carba(1-dethia)cephem or 1-oxa(1-dethia)cephem) is provided. Further provided are 3-cephams useful as intermediates to 3-cephem compounds.
    Type: Grant
    Filed: March 15, 1989
    Date of Patent: December 19, 1989
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, John M. Morin, Jr., Robert T. Vasileff
  • Difluoro antivirals and intermediate therefor
    Patent number: 4808614
    Abstract: A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.
    Type: Grant
    Filed: June 4, 1987
    Date of Patent: February 28, 1989
    Assignee: Eli Lilly and Company
    Inventor: Larry W. Hertel
  • Difluoro antivirals and intermediate therefor
    Patent number: 4692434
    Abstract: A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.
    Type: Grant
    Filed: December 4, 1984
    Date of Patent: September 8, 1987
    Assignee: Eli Lilly and Company
    Inventor: Larry W. Hertel
  • Difluoro antivirals and intermediate therefor
    Patent number: 4526988
    Abstract: A 2,2-difluoro-2-desoxycarbohydrate is used to prepare antiviral nucleosides.
    Type: Grant
    Filed: March 10, 1983
    Date of Patent: July 2, 1985
    Assignee: Eli Lilly and Company
    Inventor: Larry W. Hertel