Patents by Inventor Lars Aagaard
Lars Aagaard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9953131Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.Type: GrantFiled: September 22, 2016Date of Patent: April 24, 2018Assignee: City of HopeInventors: John J. Rossi, Ola Snove, Ali Ehsani, Pal Saetrom, Britta Vallazza, Jane Zhang, Lars Aagaard
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Publication number: 20170004254Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.Type: ApplicationFiled: September 22, 2016Publication date: January 5, 2017Applicant: CITY OF HOPEInventors: John J. ROSSI, Ola Snove, Ali Ehsani, Pal Saetrom, Britta Vallazza, Jane Zhang, Lars Aagaard
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Patent number: 9487785Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.Type: GrantFiled: December 22, 2014Date of Patent: November 8, 2016Assignee: CITY OF HOPEInventors: John J. Rossi, Ola Snove, Jr., Ali Ehsani, Pal Saetrom, Jr., Britta Vallazza, Jane Zhang, Lars Aagaard
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Publication number: 20150105450Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.Type: ApplicationFiled: December 22, 2014Publication date: April 16, 2015Applicant: CITY OF HOPEInventors: John J. ROSSI, Ola SNOVE, JR., Ali EHSANI, Pal SAETROM, JR., Britta HOEHN, Jane ZHANG, Lars AAGAARD
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Patent number: 8946401Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.Type: GrantFiled: November 2, 2011Date of Patent: February 3, 2015Assignee: City of HopeInventors: John J. Rossi, Ola Snove, Jr., Ali Ehsani, Pal Saetrom, Britta Hoehn, Jane Zhang, Lars Aagaard
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Patent number: 8435394Abstract: The application provides an assembly comprising a housing (20) having an electrical housing connector (50) and a strip port (40) for a BGM sensor arranged in the vicinity of the electrical connector. The assembly further comprises an external electrical connector (60) adapted for releasable connection to the housing connector, wherein the external electrical connector comprises a portion (62) adapted to block the port opening when the external electrical connector is connected to the housing connector, thereby preventing insertion of a strip in the port when the two connectors are connected to each other. In this way it is prevented in a simple and cost-effective manner that a patient via an inserted strip is subjected to a too high voltage or current supplied to the circuitry of the electronic device.Type: GrantFiled: March 14, 2008Date of Patent: May 7, 2013Assignee: Novo Nordisk A/SInventors: Jesper Bach Nørgaard, Lars Aagaard
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Patent number: 8394060Abstract: A reservoir unit is provided comprising a housing in which a reservoir with a transparent portion is arranged, the housing comprising a window allowing a portion of the reservoir to be inspected. The reservoir unit is adapted to be moved from a first “cold” condition to a second “warm” condition with no visible water condensing on the interior surface of the window portion. Further, the vent is adapted to provide pressure equalization between the interior of the housing and the exterior. In this way it is possible to perform visual inspection of the reservoir at all times without being confused by dew or condensed water drops, e.g. when a prefilled reservoir unit containing a drug which requires storage at a given low temperature, as is the case for insulin-containing drugs, is taken out in ambient temperature.Type: GrantFiled: March 11, 2011Date of Patent: March 12, 2013Assignee: Novo Nordisk A/SInventors: Karsten Kallesøe Nielsen, Lars Aagaard
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Publication number: 20120046343Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.Type: ApplicationFiled: November 2, 2011Publication date: February 23, 2012Applicant: CITY OF HOPEInventors: John J. ROSSI, Ola SNOVE, JR., Ali EHSANI, Pal SAETROM, Britta HOEHN, Jane ZHANG, Lars AAGAARD
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Patent number: 8071752Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.Type: GrantFiled: January 29, 2008Date of Patent: December 6, 2011Assignee: City of HopeInventors: John J. Rossi, Ola Snove, Jr., Ali Ehsani, Pal Saetrom, Jr., Britta Hoehn, Jane Zhang, Lars Aagaard
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Publication number: 20110160670Abstract: A reservoir unit is provided comprising a housing in which a reservoir with a transparent portion is arranged, the housing comprising a window allowing a portion of the reservoir to be inspected. The reservoir unit is adapted to be moved from a first “cold” condition to a second “warm” condition with no visible water condensing on the interior surface of the window portion. Further, the vent is adapted to provide pressure equalization between the interior of the housing and the exterior. In this way it is possible to perform visual inspection of the reservoir at all times without being confused by dew or condensed water drops, e.g. when a prefilled reservoir unit containing a drug which requires storage at a given low temperature, as is the case for insulin-containing drugs, is taken out in ambient temperature.Type: ApplicationFiled: March 11, 2011Publication date: June 30, 2011Applicant: Novo Nordisk A/SInventors: Karsten Kallesoe Nielsen, Lars Aagaard
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Publication number: 20100133099Abstract: The application provides an assembly comprising a housing (20) having an electrical housing connector (50) and a strip port (40) for a BGM sensor arranged in the vicinity of the electrical connector. The assembly further comprises an external electrical connector (60) adapted for releasable connection to the housing connector, wherein the external electrical connector comprises a portion (62) adapted to block the port opening when the external electrical connector is connected to the housing connector, thereby preventing insertion of a strip in the port when the two connectors are connected to each other. In this way it is prevented in a simple and cost-effective manner that a patient via an inserted strip is subjected to a too high voltage or current supplied to the circuitry of the electronic device.Type: ApplicationFiled: March 14, 2008Publication date: June 3, 2010Applicant: Novo Nordisk A/SInventors: Jesper Bach Nørgaard, Lars Aagaard, Jens Aage Munk
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Publication number: 20090118682Abstract: The invention provides a reservoir unit with a reservoir arranged within a housing. The reservoir defines an interior adapted to contain a translucent fluid drug, and comprises a first transparent area. A second area is associated with the reservoir and arranged substantially opposite the first area, the second area comprising a visually non-uniform portion. The housing comprises an inspection portion allowing a user to inspect a portion of the reservoir through the first area with the second area serving as a background, the second area thereby serving as an aid for evaluating a condition of a drug contained in the reservoir, e.g. fibrillated insulin.Type: ApplicationFiled: September 13, 2006Publication date: May 7, 2009Applicant: Novo Nordisk A/SInventors: Steffen Hansen, Per Jeppesen, Lars Aagaard, Kirsten Bundgaard-Nielsen, Anita Joan Hansen
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Publication number: 20080287870Abstract: A reservoir unit (200) is provided comprising a housing (201) in which a reservoir (250) with a transparent portion (251) is arranged, the housing comprising a window (203) allowing a portion of the reservoir to be inspected. The reservoir unit is adapted to be moved from a first “cold” condition to a second “warm” condition with no visible water condensing on the interior surface of the window portion. Further, a vent (210, 211) is adapted to provide pressure equalization between the interior of the housing and the exterior. In this way it is possible to perform visual inspection of the reservoir at all times without being confused by dew or condensed water drops, e.g. when a prefilled reservoir unit containing a drug which requires storage at a given low temperature, as is the case for insulin-containing drugs, is taken out in ambient temperature.Type: ApplicationFiled: October 17, 2006Publication date: November 20, 2008Applicant: Nov Nordisk A/SInventors: Karsten Kallesoe Nielsen, Lars Aagaard
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Publication number: 20040248083Abstract: The present invention relates to improved vectors useful in gene therapy which improvement particularly resides in improved safety of such vectors. The improvement is achieved by incorporating sequences into the gene therapy vector which promote dimer formation of transcripts derived from said vector. Such sequences are in a preferred embodiment self-complementary palindromic or nonpalindromic sequences.Type: ApplicationFiled: June 7, 2004Publication date: December 9, 2004Inventors: Jacob Giehm Mikkelsen, Soeren Vestergaard Rasmussen, Mogens Duch, Finn Skou Pedersen, Lars Aagaard