Abstract: A method of treating a bacterial infection in a subject includes administering at least a first finely divided (particulate) material, which may have at least a second material, the first material is not bioresorbable or very slowly bioresorable and the second material or materials are bioresorbable at a higher rate than the first material, allowing a certain period of time to pass in order to provide for the first particulate material to be exposed to the body and/or second material or materials to be wholly or partly absorbed by the body of the subject, and administering one or more pharmaceutically active compounds. The first material is optionally pre-loaded or soaked with one or more pharmaceutically active compounds, and the second material is optionally pre-loaded or soaked with one or more pharmaceutically active compounds. The pharmaceutically active compound is a compound capable of treating or ameliorating a bacterial infection.

Abstract: A method of treating a bacterial infection in a subject includes administering at least a first finely divided (particulate) material, which may have at least a second material, the first material is not bioresorbable or very slowly bioresorable and the second material or materials are bioresorbable at a higher rate than the first material, allowing a certain period of time to pass in order to provide for the first particulate material to be exposed to the body and/or second material or materials to be wholly or partly absorbed by the body of the subject, and administering one or more pharmaceutically active compounds. The first material is optionally pre-loaded or soaked with one or more pharmaceutically active compounds, and the second material is optionally pre-loaded or soaked with one or more pharmaceutically active compounds. The pharmaceutically active compound is a compound capable of treating or ameliorating a bacterial infection.

Abstract: A method for bone healing or treatment of bone fracture in a subject includes optionally pre-drilling a hole or creating a cavity in a body tissue, implanting a device onto or into the body tissue, or at least partially inserting a device into the cavity or hole, administering a composition into the device and/or near the device. The composition includes a first finely divided particulate material, and can optionally include at least a second material. The first material is not bioresorbable or is very slowly bioresorbable and the second material or materials are bioresorbable at a higher rate than the first material. The method can optionally include fully inserting the device into the hole or cavity, and can optionally include administering a pharmaceutical composition to the subject.

Abstract: Present invention relates to a novel composition administering pharma agents using a bi-phasic recruiting moiety.

Abstract: Device for miniinvasive ultrasound treatment of disc disease. A therapeutic ultrasound tranducer (2) is provided for treatment of the disc (5), of a patient (4) by generating an ultrasonic field (3), of which the temperature focus (F) is located in the disc (5), for heating thereof. The device comprises an optical navigating device (20) with a signal receiving or signal sending unit (32). A reference device (28) has a set position relative to the disc (5). The Therapeutic ultrasound transducer (2) is provided for insertion through the skin of the patient (4) and engagement of the disc (5), preferably anulus fibrosus (8), and it has a flexible wall with an ultrasound transmitting element provided within the flexible wall.

Abstract: The present invention relates to a device for non-invasive ultrasound treatment of disc disease. This device comprises a therapeutic ultrasound transducer (2) which is provided for treatment of the disc (5), preferably nucleus pulposus (6), of a patient (4) by generating by means of said therapeutic ultrasound transducer (2) an ultrasonic field (3), the temperature focus (F) of which is located in the disc (5), preferably nucleus pulposus (6), for heating thereof. The therapeutic ultrasound transducer (2) is of a “phased array”-type and a diagnostic ultrasound transducer (8) is provided to determine the acoustic properties of the patient's (4) tissue (10). An optical navigating device (14) comprises at least one diagnostic camera (15) and at least one signal receiving and/or signal sending unit (25) which is adapted to send or transmit signals to and/or receive reflected or other signals from position transmitters (24, 7) on a reference device (21) and on the therapeutic ultrasound transducer (2).

Abstract: In a method for producing a cement for medical use, a liquid component containing a polymerizable substance is combined with a solid component comprising a plastic substance to provide a setting mass to form the cement. In order to e.g. improve the biological and mechanical properties of the cement and allow it to be mixed by modern mixing procedures, which further improves the cement quality, said plastic substance is mixed with a particulate crystalline ceramic material prior to combining said liquid and solid components. A cement for medical use is also defined as is the use of set cement as an anchorage for the fixation of prostheses or parts of prostheses or bone and as a substitute material for bone.