Abstract: The present invention relates to conjugates targeting uPARAP, in particular antibody-drug conjugates (ADCs) comprising monoclonal antibodies directed against the N-terminal region of uPARAP, and their use in delivery of active agents to cells and tissues expressing uPARAP. The invention further relates to the use of said ADCs in the treatment of diseases involving uPARAP expressing cells, such as cancer.

Abstract: A car body for a passenger rail vehicle includes a chassis having a front assembly at each vehicle end and a vehicle floor consisting of profiled metal sheet edged in a trapezoidal-like manner within the cross-section, wherein beads of the profiled metal sheet extend in a longitudinal direction of the car body, where the vehicle floor is fixedly connected to each front assembly at transition points to the front assembly via a connecting beam oriented transversely to the longitudinal direction of the car body, where the connecting beam is formed as a profiled metal sheet having a substantially L-shaped cross-section, and where the section of the connecting beam connected to a front assembly is equipped with a trapezoidal-like bead.

Abstract: A car body for a passenger rail vehicle includes a chassis having a front assembly at each vehicle end and a vehicle floor consisting of profiled metal sheet edged in a trapezoidal-like manner within the cross-section, wherein beads of the profiled metal sheet extend in a longitudinal direction of the car body, where the vehicle floor is fixedly connected to each front assembly at transition points to the front assembly via a connecting beam oriented transversely to the longitudinal direction of the car body, where the connecting beam is formed as a profiled metal sheet having a substantially L-shaped cross-section, and where the section of the connecting beam connected to a front assembly is equipped with a trapezoidal-like bead.