Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

Abstract: A flat shaped spring may include a spring element. The spring element may have, in a longitudinal section along a central longitudinal axis extending along an axial direction, two profile halves disposed on opposite sides of the central longitudinal axis. The two profile halves may each have a first profile portion and a second profile portion. The first profile portion may have a curvature opposed to the second profile portion. Two outer ends of the spring element facing away from the central longitudinal axis, and which lie opposite one another in a longitudinal direction extending perpendicularly to the axial direction, may be connected to one another via at least one connection element such that the spring element and the at least one connection element collectively form a closed profile in the longitudinal section.

Abstract: The invention relates to double layer capacitors with which a storage of electric energy with high energy density and specific electric capacitance is possible. In the double layer capacitor, two electrodes are arranged at a spacing from one another. They are formed from porous carbon and provided with electric connector contacts. The double layer capacitor is arranged in an electrolyte or the electrodes are wetted with an electrolyte. In this respect, the carbon forming the electrode(s) was obtained from a carbide by chemical reaction for at least one electrode. A specific surface of at least 2000 m2/g and, in addition to pores having a first pore size fraction having pore sizes up to a maximum of 2 nm, additionally a second pore size fraction having a pore size larger than 2 nm up to a maximum of 20 nm should be achieved in the carbon.