Abstract: An arrangement for microscopy, having an illumination optical unit with an illumination objective for illuminating a specimen on a specimen carrier. An optical axis of the illumination objective lies in a plane which includes an illumination angle that differs from zero with the normal of a specimen plane and the illumination is implemented in the plane. A detection optical unit with a detection objective is located in a detection beam path. The optical axis of the detection objective includes a detection angle that differs from zero with the normal of the specimen plane. The illumination objective and/or the detection objective has an illumination correction element. A meniscus lens is located between the specimen carrier and the illumination and detection objectives being arranged both in the illumination beam path and in the detection beam path.

Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders such as Alzheimers disease (AD).

Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful correcting a deficient level progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).

Abstract: Packaging box for fruit, berries and vegetables comprising four side walls, a top side, and a bottom side. A portion of a side wall or the top side comprises a pour opening for tamper evident opening and pouring of content stored inside the packaging box. The pour opening comprises tear lines for opening the pour opening and means for accessing a tear grip of the opening portion.

Abstract: The invention relates to the fluid treatment, such as acid stimulation, of a subsea hydrocarbon well via a subsea wellhead/Christmas tree. Fluid is delivered directly to the subsea wellhead from a pumping vessel. Control of the delivery of fluid is from the pumping vessel via a fail-safe close valve in the delivery line. The Christmas tree subsea module is controlled directly from a host platform via a subsea cable, whilst a radio data link between the vessel and host platform provides communication of downhole data to the pumping vessel during the operation.

Abstract: Techniques are described that facilitate co-viewing in an experiential reality environment such as a virtual reality or augmented reality environment. These techniques include prioritizing a main view of experiential reality content over side views of the experiential reality content.

Abstract: Systems, devices, apparatuses, components, methods, and techniques for cadence determination and media content selection are provided. An example media-playback device comprises a media-output device that plays media content items, a cadence-acquiring device, and a cadence-based media content selection engine. The cadence-acquiring device includes an accelerometer and a cadence-determination engine configured to determine a cadence based on acceleration data captured by the accelerometer. The cadence-based media content selection engine is configured to identify a media content item based on the cadence determined by the cadence-determining engine and cause the media-output device to playback the identified media content item.

Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders such as Alzheimers disease (AD).

Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).

Abstract: Techniques are described for fulfilling an utterance request for an item represented within a video rendered at a client device. In some implementations, a user account associated with the request is identified, enabling a video stream transmitted in association with the user account at the time that the request was uttered to be identified. In one technique, a timestamp associated with the request is used to identify the relevant portion of the video stream. The item represented within the portion of the video stream can be identified using various techniques and/or information such as image recognition, metadata within the video, subtitles, closed captions, and/or a database mapping between the item and a video content item transmitted in the video stream.

Abstract: A system for supporting a user's repetitive motion activity operates to manage cadence-based playlists identifying one or more media content items having a tempo corresponding to a user's cadence. The cadence-based playlists can be categorized by different tempi or tempo ranges that cover all likely cadences during the user's activities. A media-playback device is provided to acquire a user's cadence and retrieve a cadence-based playlist associated with a tempo or a tempo range corresponding to the cadence.

Abstract: An anti-squeal shim includes at least a first metal layer and an elastomer layer that is bonded to the first metal layer. The at least first metal layer is configured as a first electrode for electrical connection to a resistance measuring system, and the elastomer layer is configured with structural spatial features that enable the elastomer layer to obtain a reduced thickness when subjected to a mechanical force in a direction perpendicular to the elastomer layer.

Abstract: The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunosiained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions tire useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.

Abstract: A fragment-free propulsion of a cartridge-type ammunition, including a propellant casing and a high-pressure chamber, wherein the high-pressure chamber accommodates a propellant powder and, in the bottom region, a primer, having at least one overflow bore. To avoid fragments, a membrane, which separates the high-pressure chamber and a low-pressure chamber from one another and which does not tear to connect the high-pressure chamber to the low-pressure chamber when pressure is built up but instead is bent, is embedded in the high-pressure chamber. For this purpose, the high-pressure chamber additionally has a cap, the membrane, and a body. The membrane is embedded in the body and is secured by the cap. In addition, the membrane covers a gap that is formed by an outer diameter of the cap and an inner diameter of the body, and into which the membrane is bent when pressure is built up.

Abstract: A metrology apparatus (302) includes a higher harmonic generation (HHG) radiation source for generating (310) EUV radiation. Operation of the HHG source is monitored using a wavefront sensor (420) which comprises an aperture array (424, 702) and an image sensor (426). A grating (706) disperses the radiation passing through each aperture so that the image detector captures positions and intensities of higher diffraction orders for different spectral components and different locations across the beam. In this way, the wavefront sensor can be arranged to measure a wavefront tilt for multiple harmonics at each location in said array. In one embodiment, the apertures are divided into two subsets (A) and (B), the gratings (706) of each subset having a different direction of dispersion. The spectrally resolved wavefront information (430) is used in feedback control (432) to stabilize operation of the HGG source, and/or to improve accuracy of metrology results.

Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).

Abstract: A metrology apparatus (302) includes a higher harmonic generation (HHG) radiation source for generating (310) EUV radiation. Operation of the HHG source is monitored using a wavefront sensor (420) which comprises an aperture array (424, 702) and an image sensor (426). A grating (706) disperses the radiation passing through each aperture so that the image detector captures positions and intensities of higher diffraction orders for different spectral components and different locations across the beam. In this way, the wavefront sensor can be arranged to measure a wavefront tilt for multiple harmonics at each location in said array. In one embodiment, the apertures are divided into two subsets (A) and (B), the gratings (706) of each subset having a different direction of dispersion. The spectrally resolved wavefront information (430) is used in feedback control (432) to stabilize operation of the HGG source, and/or to improve accuracy of metrology results.

Abstract: The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions are useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.

Abstract: A system for supporting a user's repetitive motion activity operates to manage cadence-based playlists identifying one or more media content items having a tempo corresponding to a user's cadence. The cadence-based playlists can be categorized by different tempi or tempo ranges that cover all likely cadences during the user's activities. A media-playback device is provided to acquire a user's cadence and retrieve a cadence-based playlist associated with a tempo or a tempo range corresponding to the cadence.

Abstract: Techniques are described that facilitate co-viewing in an experiential reality environment such as a virtual reality or augmented reality environment. These techniques include prioritizing a main view of experiential reality content over side views of the experiential reality content.