Abstract: The present invention provides a method of calibrating gamma-ray and photon counting detectors, including, but not limited to, monolithic crystal detectors. The method of the present invention is based on the observation that measurement of fan beam datasets allows the synthesis of collimated beam data to derive MDRFs by use of an algorithm that finds the common or intersecting data subsets of two or more orthogonal calibration datasets. This makes the calibration process very efficient while still allowing the full benefits of maximum-likelihood event-parameter estimation that incorporates the statistical nature of the light sensor measurements.

Abstract: A scintillation-crystal based gamma-ray detector with photon sensors disposed on edge surface(s) of the crystal to take advantage of total internal reflection of scintillation photons within the thin-slab detector substrate to improve spatial resolution of determination of a scintillation event (including depth-of-interaction resolution) while preserving energy resolution and detection efficiency. The proposed structure benefits from the reduced—as compared with related art—total number of readout channels elimination of need in complicated and repetitive cutting and polishing operations to form pixelated crystal arrays used in conventional PET detector modules. Detectors systems utilizing stacks of such detectors, and methods of operation of same.

Abstract: The present invention provides a method of calibrating gamma-ray and photon counting detectors, including, but not limited to, monolithic crystal detectors. The method of the present invention is based on the observation that measurement of fan beam datasets allows the synthesis of collimated beam data to derive MDRFs by use of an algorithm that finds the common or intersecting data subsets of two or more orthogonal calibration datasets. This makes the calibration process very efficient while still allowing the full benefits of maximum-likelihood event-parameter estimation that incorporates the statistical nature of the light sensor measurements.

Abstract: The present invention provides a method of calibrating gamma-ray and photon counting detectors, including, but not limited to, monolithic crystal detectors. The method of the present invention is based on the observation that measurement of fan beam datasets allows the synthesis of collimated beam data to derive MDRFs by use of an algorithm that finds the common or intersecting data subsets of two or more orthogonal calibration datasets. This makes the calibration process very efficient while still allowing the full benefits of maximum-likelihood event-parameter estimation that incorporates the statistical nature of the light sensor measurements.

Abstract: The invention provides a novel arrangement of photon sensors on a scintillation-crystal based gamma-ray detector that takes advantage of total internal reflection of scintillation light within the scintillation detector substrate. The present invention provides improved spatial resolution including depth-of-interaction (DOI) resolution while preserving energy resolution and detection efficiency, which is especially useful in small-animal or human positron emission tomography (PET) or other techniques that depend on high-energy gamma-ray detection. Moreover, the new geometry helps reduce the total number of readout channels required and eliminates the need to do complicated and repetitive cutting and polishing operations to form pixelated crystal arrays as is the standard in current PET detector modules.

Abstract: A scintillation-crystal based gamma-ray detector with photon sensors disposed on edge surface(s) of the crystal to take advantage of total internal reflection of scintillation photons within the thin-slab detector substrate to improve spatial resolution of determination of a scintillation event (including depth-of-interaction resolution) while preserving energy resolution and detection efficiency. The proposed structure benefits from the reduced—as compared with related art—total number of readout channels elimination of need in complicated and repetitive cutting and polishing operations to form pixelated crystal arrays used in conventional PET detector modules. Detectors systems utilizing stacks of such detectors, and methods of operation of same.

Abstract: Disclosed are fast gamma-ray interaction-position estimation methods using k-d tree searching. Compared with conventional methods, the methods disclosed herein achieve both high levels of speed and accuracy using k-d tree data structures. The k-d tree search methods have a time complexity of O(log x(N)), where x is the number of branches at each node and N is the number of entries in the reference data set, which means larger reference datasets can be used to efficiently estimate each event's interaction position. The accuracy of methods described herein was found to be equal to the exhaustive search method, yielding the highest achievable accuracy. Most importantly, the disclosed methods have no restriction on the data structure of the reference dataset and can work with complicated mean detector response functions (MDRFs), meaning it is more robust compared with other methods such as contracting grid (CG) search or vector search (VS) methods.

Abstract: The present invention provides a method of calibrating gamma-ray and photon counting detectors, including, but not limited to, monolithic crystal detectors. The method of the present invention is based on the observation that measurement of fan beam datasets allows the synthesis of collimated beam data to derive MDRFs by use of an algorithm that finds the common or intersecting data subsets of two or more orthogonal calibration datasets. This makes the calibration process very efficient while still allowing the full benefits of maximum-likelihood event-parameter estimation that incorporates the statistical nature of the light sensor measurements.

Abstract: The invention provides a novel arrangement of photon sensors on a scintillation-crystal based gamma-ray detector that takes advantage of total internal reflection of scintillation light within the scintillation detector substrate. The present invention provides improved spatial resolution including depth-of-interaction (DOI) resolution while preserving energy resolution and detection efficiency, which is especially useful in small-animal or human positron emission tomography (PET) or other techniques that depend on high-energy gamma-ray detection. Moreover, the new geometry helps reduce the total number of readout channels required and eliminates the need to do complicated and repetitive cutting and polishing operations to form pixelated crystal arrays as is the standard in current PET detector modules.

Abstract: An apparatus for estimating a wavefront parameter includes a light source, a lenslet array, a detector for detecting light generated by the light source and passed through the lenslet array, a wavefront corrective element disposed between the lenslet array and the light source; and a data analyzer configured to estimate at least one wavefront parameter at a plane located on the light source side of the corrective element. The lenslet array and the sensor array are arranged to form a wavefront sensor, and the wavefront corrective element is configured to correct an aberration of the wavefront.

Abstract: An apparatus for estimating a wavefront parameter includes a light source, a lenslet array, a detector for detecting light generated by the light source and passed through the lenslet array, a wavefront corrective element disposed between the lenslet array and the light source; and a data analyzer configured to estimate at least one wavefront parameter at a plane located on the light source side of the corrective element. The lenslet array and the sensor array are arranged to form a wavefront sensor, and the wavefront corrective element is configured to correct an aberration of the wavefront.