Abstract: The present invention relates to a solution for solving an ill-posed inverse problem in image analysis, e.g. in an electron tomography application in order to recover a structure of a sample. The solution is provided for instance as a method comprising steps of determining reliable prior knowledge about the solution, determining initial guess for the solution and determining the corresponding forward operator, deciding upon model of stochasticity, deciding on suitable regularization method, deciding on updating scheme, and producing a sequence using the set configuration.