Patents by Inventor Lars H. Björck

Lars H. Björck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Streptoccal inhibitor of complement-mediated lysis, protein SIC
    Patent number: 7588762
    Abstract: A protein from Streptococcus pyogenes, serotype Ml has been characterized. This protein, called protein SIC, plays a role in S. pyogenes pathogenicity and virulence. It inhibits hemolysis by interacting with the plasma proteins clusterin, and members of the cystatin protein super family such as histidine rich glycoprotein (HRG). The protein, comprises at least one of the following partial amino acid sequences: (a) glu thr tyr thr ser arg asn phe; (b) asp trp ser gly asp asp trp pro glu asp asp trp; Cc) arg ser gly val gly leu ser gln tyr gly trp ser; (d) trp ser ser asp lys lys asp glu thr glu asp lys thr; (e) gly thr gly tyr glu lys arg asp asp trp gly gly pro gly; (f) lys arg asp asp trp arg gly pro gly his ile pro lys pro. The protein and antibodies specific for the protein can be used in analytical procedures for determining the presence of virulent Streptococcus pyo genes in a sample. The protein can also be used in vaccine compositions.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: September 15, 2009
    Assignee: Genovis AB
    Inventors: Per Åkesson, Lars H. Björck, Anders Sjohölm
  • Streptoccal inhibitor of complement-mediated lysis, protein SIC
    Patent number: 7361750
    Abstract: A protein from Streptococcus pyogenes, serotype M1 has been characterized. This protein, called protein SIC, plays a role in S. pyogenes pathogenicity and virulence. It inhibits hemolysis by interacting with the plasma proteins clusterin, and members of the cystatin protein super family such as histidine rich glycoprotein (HRG). The protein comprises at least one of the following partial amino acid sequences: (a) glu thr tyr thr ser arg asn phe; (b) asp trp ser gly asp asp trp pro glu asp asp trp; (c) arg ser gly val gly leu ser gln tyr gly trp ser; (d) trp ser ser asp lys lys asp glu thr glu asp lyr thr; (e) gly thr gly tyr glu lys arg asp asp trp gly gly pro gly; and (f) lys arg asp asp trp arg gly pro gly his ile pro lys pro. The protein and antibodies specific for the protein can be used in analytical procedures for determining the presence of virulent Streptococcus pyogenes in a sample. The protein can also be used in vaccine compositions.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: April 22, 2008
    Assignee: Genovis AB
    Inventors: Per Akesson, Lars H. Björck, Anders Sjoholm
  • Use of protein H as cytostatic agent
    Patent number: 6833355
    Abstract: The use of protein H, and fragments or derivatives thereof, as cytostatic agents, especially in the treatment of diseases involving undesired cell proliferation.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: December 21, 2004
    Assignee: Hansa Medical AB
    Inventors: Lars H. Björck, Inga-Maria Frick, Tomas Borje Leandersson, Eugen Jan Karol Axcrona