Patents by Inventor Lars Heslet

Lars Heslet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of alleviating chronic wounds
    Patent number: 11813309
    Abstract: The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor (GM-CSF), sucrose octasulfate or sucralfate and hyaluronic acid for the treatment, pre-emptive treatment or prophylaxis of ulcers, wounds and other injuries to the skin or membranes of the body. Other aspects of the invention are methods of treatment or prevention using the compositions described, as well as an application device for use in the methods provided.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: November 14, 2023
    Assignee: Reponex Pharmaceuticals APS
    Inventor: Lars Heslet
  • Methods and compositions for enhancing pulmonary host defense in acute and chronic radiation syndrome, therapeutic radiation intervention and cancer therapy
    Patent number: 11426449
    Abstract: Methods and compositions for treating and alleviating symptoms of irradiation injuries, therapeutic radiation intervention and/or anti-cancer therapies in a subject via pulmonary airway administration of granulocyte macrophage colony stimulating factor (GM-CSF) or a compound with similar affinity to the specific alveolar GM-CSF receptor to enhance pulmonary host defense are provided.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: August 30, 2022
    Assignee: REPONEX PHARMACEUTICALS A/S
    Inventor: Lars Heslet
  • COMPOSITIONS TO PROMOTE THE HEALING OF SKIN ULCERS AND WOUNDS
    Publication number: 20220218792
    Abstract: The present invention provides compositions comprising as an essential feature granulocyte-macrophage colony-stimulating factor (GM-CSF) together with fosfomycin for the treatment of wounds, ulcers, sores, burns and other injuries to the skin or mucous membranes of the body.
    Type: Application
    Filed: August 20, 2021
    Publication date: July 14, 2022
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • COMPOSITIONS FOR TREATING LUNG INFECTIONS BY AIRWAY ADMINISTRATION
    Publication number: 20210121528
    Abstract: The present invention provides compositions comprising as an essential feature granulocyte-macrophage colony-stimulating factor (GM-CSF) together with fosfomycin for the treatment of bacterial lung infections by administration via the air-ways.
    Type: Application
    Filed: June 9, 2020
    Publication date: April 29, 2021
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • COMPOSITIONS TO PROMOTE THE HEALING OF SKIN ULCERS AND WOUNDS
    Publication number: 20200254062
    Abstract: The present invention provides compositions comprising as an essential feature granulocyte-macrophage colony-stimulating factor (GM-CSF) together with fosfomycin for the treatment of wounds, ulcers, sores, burns and other injuries to the skin or mucous membranes of the body.
    Type: Application
    Filed: October 8, 2019
    Publication date: August 13, 2020
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • Methods for inhibiting infectious peritonitis
    Patent number: 10716831
    Abstract: The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor and antimicrobial agents for the treatment, pre-emptive treatment or prevention of infectious peritonitis or intra-abdominal infection by intraperitoneal administration of the compositions.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: July 21, 2020
    Assignee: REPONEX PHARMACEUTICALS A/S
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • COMPOSITIONS FOR PROMOTING THE HEALING OF WOUNDS
    Publication number: 20200030410
    Abstract: The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor (GM-CSF), sucrose octasulfate or sucralfate and hyaluronic acid for the treatment, pre-emptive treatment or prophylaxis of ulcers, wounds and other injuries to the skin or membranes of the body. Other aspects of the invention are methods of treatment or prevention using the compositions described, as well as an application device for use in the methods provided.
    Type: Application
    Filed: March 27, 2019
    Publication date: January 30, 2020
    Inventor: Lars Heslet
  • COMPOSITIONS FOR THE TREATMENT OF PERITONITIS
    Publication number: 20190275107
    Abstract: The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor and antimicrobial agents for the treatment, pre-emptive treatment or prevention of infectious peritonitis or intra-abdominal infection by intraperitoneal administration of the compositions.
    Type: Application
    Filed: October 18, 2018
    Publication date: September 12, 2019
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • Compositions comprising granulocyte-macrophage colony-stimulating factor for the treatment of inflammatory bowel disease
    Patent number: 10105415
    Abstract: The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor and fosfomycin for the treatment, prevention or alleviation of an inflammatory bowel disease such as Crohn's disease, ulcerative colitis or necrotizing enterocolitis of newborn and premature infants by administration of the compositions into the intestinal lumen.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: October 23, 2018
    Assignee: Reponex Pharmaceuticals A/S
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • COMPOSITIONS FOR TREATING LUNG INFECTIONS BY AIRWAY ADMINISTRATION
    Publication number: 20180289773
    Abstract: The present invention provides compositions comprising as an essential feature granulocyte-macrophage colony-stimulating factor (GM-CSF) together with fosfomycin for the treatment of bacterial lung infections by administration via the air-ways.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 11, 2018
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • Methods and Compositions for Enhancing Pulmonary Host Defense in Acute and Chronic Radiation Syndrome, Therapeutic Radiation Intervention and Cancer Therapy
    Publication number: 20180078614
    Abstract: Methods and compositions for treating and alleviating symptoms of irradiation injuries, therapeutic radiation intervention and/or anti-cancer therapies in a subject via pulmonary airway administration of granulocyte macrophage colony stimulating factor (GM-CSF) or a compound with similar affinity to the specific alveolar GM-CSF receptor to enhance pulmonary host defense are provided.
    Type: Application
    Filed: November 27, 2017
    Publication date: March 22, 2018
    Applicant: REPONEX PHARMACEUTICALS APS
    Inventor: Lars Heslet
  • Granulocyte-macrophage colony stimulating factor for enhancing pulmonary host defense in acute and chronic radiation syndrome, therapeutic radiation intervention and cancer therapy
    Patent number: 9855316
    Abstract: Methods and compositions for treating and alleviating symptoms of irradiation injuries, therapeutic radiation intervention and/or anti-cancer therapies in a subject via pulmonary airway administration of granulocyte macrophage colony stimulating factor (GM-CSF) or a compound with similar affinity to the specific alveolar GM-CSF receptor to enhance pulmonary host defense are provided.
    Type: Grant
    Filed: April 10, 2012
    Date of Patent: January 2, 2018
    Assignee: REPONEX PHARMACEUTICALS APS
    Inventor: Lars Heslet
  • COMPOSITIONS FOR THE TREATMENT OF PERITONITIS
    Publication number: 20170232069
    Abstract: The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor and antimicrobial agents for the treatment, pre-emptive treatment or prevention of infectious peritonitis or intra-abdominal infection by intraperitoneal administration of the compositions.
    Type: Application
    Filed: August 7, 2015
    Publication date: August 17, 2017
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • COMPOSITIONS COMPRISING GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE
    Publication number: 20170196937
    Abstract: The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor and fosfomycin for the treatment, prevention or alleviation of an inflammatory bowel disease such as Crohn's disease, ulcerative colitis or necrotizing enterocolitis of newborn and premature infants by administration of the compositions into the intestinal lumen.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 13, 2017
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • COMPOSITIONS FOR PROMOTING THE HEALING OF WOUNDS
    Publication number: 20170182125
    Abstract: The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor (GM-CSF), sucrose octasulfate or sucralfate and hyaluronic acid for the treatment, pre-emptive treatmentor prophylaxis of ulcers, wounds and other injuries to the skin or membranes of the body. Other aspects of the invention are methods of treatment or prevention using the compositions described, as well as an application device for use in the methods provided.
    Type: Application
    Filed: May 26, 2015
    Publication date: June 29, 2017
    Inventor: Lars Heslet
  • COMPOSITIONS FOR TREATING LUNG INFECTIONS BY AIRWAY ADMINISTRATION
    Publication number: 20170035850
    Abstract: The present invention provides compositions comprising as an essential feature granulocyte-macrophage colony-stimulating factor (GM-CSF) together with fosfomycin for the treatment of bacterial lung infections by administration via the airways.
    Type: Application
    Filed: March 6, 2015
    Publication date: February 9, 2017
    Applicant: Reponex Pharmaceuticals ApS
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • COMPOSITIONS TO PROMOTE THE HEALING OF SKIN ULCERS AND WOUNDS
    Publication number: 20160346354
    Abstract: The present invention provides compositions comprising as an essential feature granulocyte-macrophage colony-stimulating factor (GM-CSF) together with fosfomycin for the treatment of wounds, ulcers, sores, burns and other injuries to the skin or mucous membranes of the body.
    Type: Application
    Filed: February 5, 2015
    Publication date: December 1, 2016
    Inventors: Lars Heslet, Lars Otto Uttenthal
  • COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING RADIATION- OR CHEMOTHERAPY-INDUCED PULMONARY DYSFUNCTION
    Publication number: 20160256528
    Abstract: Compositions comprising one or more cytokines and methods for their use in inhibiting and/or alleviating effects of radiation therapy and/or chemotherapy and/or acute radiation syndrome in a subject in need thereof are provided.
    Type: Application
    Filed: November 6, 2015
    Publication date: September 8, 2016
    Inventor: Lars Heslet
  • GM-CSF FOR TREATMENT OF CHRONIC ORAL MUCOSITIS
    Publication number: 20160000875
    Abstract: The present invention relates to compositions comprising granulocyte-macrophage colony-stimulating factor (GM-CSF), or homologues thereof, and its use for treatment, prevention or alleviation of oral mucositis. The composition is preferably an aqueous solution forlocaloral administration.
    Type: Application
    Filed: February 19, 2014
    Publication date: January 7, 2016
    Applicant: Reponex Pharmaceuticals ApS
    Inventor: Lars Heslet
  • GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR FOR THE TREATMENT OF BRONCHIAL ASTHMA
    Publication number: 20150174204
    Abstract: The present invention relates to granulocyte-macrophage colony-stimulating factor (GM-CSF) for use in the treatment of bronchial asthma by administering via the airway an effective amount of GM-CSF or a functional homologue thereof. The invention further relates to a method for treating bronchial asthma comprising the administration of GM-CSF to a patient in need thereof, in particular moderate and severe forms of bronchial asthma.
    Type: Application
    Filed: July 19, 2013
    Publication date: June 25, 2015
    Applicant: Reponex Pharmaceuticals Aps
    Inventor: Lars Heslet