Patents by Inventor Lars Jonson

Lars Jonson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense oligonucleotide for targeting progranulin
    Patent number: 12104153
    Abstract: The present invention relates to oligonucleotides which alter the splicing pattern of progranulin in cells, and their use in the treatment of neurological disorders.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: October 1, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ravi Jagasia, Lars Jonson, Soren Rasmussen, Jacob Ravn, Disa Tehler, Dorthe Vang, Jesper Worm
  • Antisense Oligonucleotide for Targeting Progranulin
    Publication number: 20220204973
    Abstract: The present invention relates to oligonucleotides which alter the splicing pattern of progranulin in cells, and their use in the treatment of neurological disorders.
    Type: Application
    Filed: December 16, 2021
    Publication date: June 30, 2022
    Inventors: Ravi Jagasia, Lars Jonson, Soren Rasmussen, Jacob Ravn, Disa Tehler, Dorthe Vang, Jesper Worm
  • Methods for increasing the production of a recombinant polypeptide from a host cell
    Publication number: 20060121565
    Abstract: The present invention provides a host cell comprising a nucleic acid sequence encoding a recombinant polypeptide in which the production of a naturally occurring metalloprotease comprising a sequence provided in SEQ ID NO:1 has been reduced or inhibited by genetic manipulation. The present invention also relates to methods for enhancing the production of a polypeptide from a cell by disrupting the synthesis or activity of the metalloprotease. In particular, the present invention relates to methods for enhancing the secretion of recombinant polypeptides from host cells such as, but not limited to, yeast and bacterial cells. The metalloprotease is a member of the pitrilysin subfamily of proteases, characterized by comprising the sequence HXXEH (SEQ ID NO:1), where X is any amino acid.
    Type: Application
    Filed: September 19, 2003
    Publication date: June 8, 2006
    Inventors: Lars Jonson, Jens Rehfeld, Anders Johnsen